5wrs - Revision history

OCA at 16:52, 8 November 2023

OCA — Wed, 08 Nov 2023 16:52:20 GMT

←Older revision		Revision as of 16:52, 8 November 2023
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	<StructureSection load='5wrs' size='340' side='right'caption='[[5wrs]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='5wrs' size='340' side='right'caption='[[5wrs]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wrs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WRS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5WRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wrs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WRS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5wrr\|5wrr]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">FAM20A, UNQ9388/PRO34279 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wrs OCA], [https://pdbe.org/5wrs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wrs RCSB], [https://www.ebi.ac.uk/pdbsum/5wrs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wrs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wrs OCA], [~~http~~://pdbe.org/5wrs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wrs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wrs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wrs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Amelogenesis imperfecta - nephrocalcinosis;Amelogenesis imperfecta and gingival hyperplasia syndrome. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN] Amelogenesis imperfecta - nephrocalcinosis;Amelogenesis imperfecta and gingival hyperplasia syndrome. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<ref>PMID:25789606</ref>	+	[https://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN] Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<ref>PMID:25789606</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Zhu, Q]]	+	[[Category: Zhu Q]]
-	~~[[Category: Secretory pathway pseudokinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:15, 7 October 2020

OCA — Wed, 07 Oct 2020 07:15:35 GMT

←Older revision		Revision as of 07:15, 7 October 2020
Line 1:		Line 1:

	==Crystal Structure of Fam20A in complex with ATP==		==Crystal Structure of Fam20A in complex with ATP==
-	<StructureSection load='5wrs' size='340' side='right' caption='[[5wrs]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='5wrs' size='340' side='right'caption='[[5wrs]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wrs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WRS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WRS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wrs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WRS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WRS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wrr\|5wrr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wrr\|5wrr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wrs OCA], [http://pdbe.org/5wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wrs RCSB], [http://www.ebi.ac.uk/pdbsum/5wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wrs ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FAM20A, UNQ9388/PRO34279 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wrs OCA], [http://pdbe.org/5wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wrs RCSB], [http://www.ebi.ac.uk/pdbsum/5wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wrs ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Zhu, Q]]		[[Category: Zhu, Q]]
	[[Category: Secretory pathway pseudokinase]]		[[Category: Secretory pathway pseudokinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:11, 24 May 2017

OCA — Wed, 24 May 2017 07:11:37 GMT

←Older revision		Revision as of 07:11, 24 May 2017
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<ref>PMID:25789606</ref>		[[http://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<ref>PMID:25789606</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mutations in FAM20A cause tooth enamel defects known as Amelogenesis Imperfecta (AI) and renal calcification. We previously showed that Fam20A is a secretory pathway pseudokinase and allosterically activates the physiological casein kinase Fam20C to phosphorylate secreted proteins important for biomineralization (Cui et al., 2015). Here we report the nucleotide-free and ATP-bound structures of Fam20A. Fam20A exhibits a distinct disulfide bond pattern mediated by a unique insertion region. Loss of this insertion due to abnormal mRNA splicing interferes with the structure and function of Fam20A, resulting in AI. Fam20A binds ATP in the absence of divalent cations, and strikingly, ATP is bound in an inverted orientation compared to other kinases. Fam20A forms a dimer in the crystal, and residues in the dimer interface are critical for Fam20C activation. Together, these results provide structural insights into the function of Fam20A and shed light on the mechanism by which Fam20A mutations cause disease.
		+
		+	Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding.,Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J Elife. 2017 Apr 22;6. pii: e23990. doi: 10.7554/eLife.23990. PMID:28432788<ref>PMID:28432788</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5wrs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:13, 4 May 2017

OCA — Thu, 04 May 2017 13:13:44 GMT

←Older revision		Revision as of 13:13, 4 May 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wrs is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Fam20A in complex with ATP==
-		+	<StructureSection load='5wrs' size='340' side='right' caption='[[5wrs]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~Authors~~: ~~Zhu~~, Q.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5wrs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WRS FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Fam20A~~ in ~~complex with ATP~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wrr\|5wrr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wrs OCA], [http://pdbe.org/5wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wrs RCSB], [http://www.ebi.ac.uk/pdbsum/5wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wrs ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Amelogenesis imperfecta - nephrocalcinosis;Amelogenesis imperfecta and gingival hyperplasia syndrome. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA20A_HUMAN FA20A_HUMAN]] Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.<ref>PMID:25789606</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Zhu, Q]]		[[Category: Zhu, Q]]
		+	[[Category: Secretory pathway pseudokinase]]
		+	[[Category: Transferase]]

OCA at 12:25, 27 April 2017

OCA — Thu, 27 Apr 2017 12:25:36 GMT

←Older revision		Revision as of 12:25, 27 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wrs is ON HOLD	+	The entry 5wrs is ON HOLD until Paper Publication

	Authors: Zhu, Q.		Authors: Zhu, Q.

OCA at 20:38, 22 December 2016

OCA — Thu, 22 Dec 2016 20:38:21 GMT

←Older revision		Revision as of 20:38, 22 December 2016
Line 3:		Line 3:
	The entry 5wrs is ON HOLD		The entry 5wrs is ON HOLD

-	Authors: Zhu, ~~Qinyu~~	+	Authors: Zhu, Q.

	Description: Crystal Structure of Fam20A in complex with ATP		Description: Crystal Structure of Fam20A in complex with ATP
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Zhu, ~~Qinyu~~]]	+	[[Category: Zhu, Q]]

OCA: Protected "5wrs" [edit=sysop:move=sysop]

OCA — Thu, 15 Dec 2016 17:54:12 GMT

Protected "5wrs" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:54, 15 December 2016

OCA: New page: '''Unreleased structure''' The entry 5wrs is ON HOLD Authors: Zhu, Qinyu Description: Crystal Structure of Fam20A in complex with ATP Category: Unreleased Structures [[Category: Zh...

OCA — Thu, 15 Dec 2016 17:54:11 GMT

New page: '''Unreleased structure''' The entry 5wrs is ON HOLD Authors: Zhu, Qinyu Description: Crystal Structure of Fam20A in complex with ATP Category: Unreleased Structures [[Category: Zh...

New page

'''Unreleased structure'''

The entry 5wrs is ON HOLD

Authors: Zhu, Qinyu

Description: Crystal Structure of Fam20A in complex with ATP
[[Category: Unreleased Structures]]
[[Category: Zhu, Qinyu]]