5wtd - Revision history

OCA at 16:53, 8 November 2023

OCA — Wed, 08 Nov 2023 16:53:42 GMT

←Older revision		Revision as of 16:53, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5wtd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WTD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5wtd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WTD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.501Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtd OCA], [https://pdbe.org/5wtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wtd RCSB], [https://www.ebi.ac.uk/pdbsum/5wtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtd OCA], [https://pdbe.org/5wtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wtd RCSB], [https://www.ebi.ac.uk/pdbsum/5wtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>	+	[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.	+	[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 30:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hao, Q]]	+	[[Category: Hao Q]]
-	[[Category: Lai~~, T P~~]]	+	[[Category: Lai TP]]
-	[[Category: Sun, H]]	+	[[Category: Sun H]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Ruthenium transferrin n-lobe~~]]	+

OCA at 09:49, 22 June 2022

OCA — Wed, 22 Jun 2022 09:49:50 GMT

←Older revision		Revision as of 09:49, 22 June 2022
Line 3:		Line 3:
	<StructureSection load='5wtd' size='340' side='right'caption='[[5wtd]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5wtd' size='340' side='right'caption='[[5wtd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wtd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5WTD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wtd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WTD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5wtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtd OCA], [~~http~~://pdbe.org/5wtd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wtd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wtd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtd OCA], [https://pdbe.org/5wtd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wtd RCSB], [https://www.ebi.ac.uk/pdbsum/5wtd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[~~http~~://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>	+	[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[https://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.	+	[[https://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Being identified with less toxic and generally showing selective effects for solid tumor metastases, ruthenium and osmium compounds are promising drug candidates for clinical uses. Human serum proteins, such as albumin and transferrin, play vital roles in the transportation and accumulation of ruthenium and osmium agents into target tissues. However, the molecular mechanism of how transferrin transport ruthenium and their osmium analogues at atomic level remains obscure. In this study, we uncovered that the cellular uptake of Os(3+) or Ru(3+) are not competed by Fe(3+). To unveil the molecular mechanism behind the phenomena, we report the first crystal structures of human serum transferrin (hTF) in complex with ruthenium and osmium compounds bound to the non-conserved residues on the surface of hTF without altering its overall conformation. As for Ru(3+) and Os(3+), these binding sites by descending affinity are: His14/His289, His349-350 ~ His578/Arg581. Ruthenium drugs and their osmium analogues preferentially bind to His14/His289 with bipyridine or imidazole ligands leaving. These binding sites on hTF surface are also available in human lactoferrin and some transferrin family member of other species. The presence of these binding sites makes the cellular uptake of Ru(3+) and Os(3+) less affected by Fe(3+), compare to Zr(4+) or Hf(4+). Collectively, these findings are critical for our understanding of the role of serum transferrin in cellular delivery of ruthenium and osmium anticancer agents.
		+
		+	Binding of ruthenium and osmium at noniron sites of transferrin accounts for their iron-independent cellular uptake.,Wang M, Wang H, Xu X, Lai TP, Zhou Y, Hao Q, Li H, Sun H J Inorg Biochem. 2022 Jun 2;234:111885. doi: 10.1016/j.jinorgbio.2022.111885. PMID:35690040<ref>PMID:35690040</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5wtd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:16, 7 October 2020

OCA — Wed, 07 Oct 2020 07:16:33 GMT

←Older revision		Revision as of 07:16, 7 October 2020
Line 1:		Line 1:

	==Structure of human serum transferrin bound ruthenium at N-lobe==		==Structure of human serum transferrin bound ruthenium at N-lobe==
-	<StructureSection load='5wtd' size='340' side='right' caption='[[5wtd]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5wtd' size='340' side='right'caption='[[5wtd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wtd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WTD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wtd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WTD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtd OCA], [http://pdbe.org/5wtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wtd RCSB], [http://www.ebi.ac.uk/pdbsum/5wtd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtd OCA], [http://pdbe.org/5wtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wtd RCSB], [http://www.ebi.ac.uk/pdbsum/5wtd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtd ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.		[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
		+
		+	==See Also==
		+	*[[Transferrin 3D structures\|Transferrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 16:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]
	[[Category: Lai, T P]]		[[Category: Lai, T P]]

OCA at 06:19, 20 December 2017

OCA — Wed, 20 Dec 2017 06:19:15 GMT

←Older revision		Revision as of 06:19, 20 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wtd is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Structure of human serum transferrin bound ruthenium at N-lobe==
-		+	<StructureSection load='5wtd' size='340' side='right' caption='[[5wtd]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5wtd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WTD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wtd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtd OCA], [http://pdbe.org/5wtd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wtd RCSB], [http://www.ebi.ac.uk/pdbsum/5wtd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtd ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Hao, Q]]
		+	[[Category: Lai, T P]]
		+	[[Category: Sun, H]]
		+	[[Category: Wang, M]]
		+	[[Category: Zhang, H]]
		+	[[Category: Metal transport]]
		+	[[Category: Ruthenium transferrin n-lobe]]

OCA at 15:51, 4 January 2017

OCA — Wed, 04 Jan 2017 15:51:07 GMT

←Older revision		Revision as of 15:51, 4 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wtd is ON HOLD	+	The entry 5wtd is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5wtd" [edit=sysop:move=sysop]

OCA — Thu, 22 Dec 2016 20:41:18 GMT

Protected "5wtd" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:41, 22 December 2016

OCA: New page: '''Unreleased structure''' The entry 5wtd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 22 Dec 2016 20:41:16 GMT

New page: '''Unreleased structure''' The entry 5wtd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wtd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]