5wvr - Revision history

OCA at 07:49, 22 November 2023

OCA — Wed, 22 Nov 2023 07:49:08 GMT

←Older revision		Revision as of 07:49, 22 November 2023
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	<StructureSection load='5wvr' size='340' side='right'caption='[[5wvr]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5wvr' size='340' side='right'caption='[[5wvr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wvr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Candida_sphaerica Candida sphaerica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WVR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5WVR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WVR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~KLLA0_C04147g ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=284590 Candida sphaerica])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5wvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wvr OCA], [~~http~~://pdbe.org/5wvr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wvr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wvr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wvr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wvr OCA], [https://pdbe.org/5wvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wvr RCSB], [https://www.ebi.ac.uk/pdbsum/5wvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wvr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6CUK7_KLULA Q6CUK7_KLULA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Candida sphaerica~~]]	+	[[Category: Kluyveromyces lactis NRRL Y-1140]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Im~~, Y J~~]]	+	[[Category: Im YJ]]
-	[[Category: Manik~~, M K~~]]	+	[[Category: Manik MK]]
-	[[Category: Tong~~, J S~~]]	+	[[Category: Tong JS]]
-	[[Category: Yang~~, H S]]~~	+	[[Category: Yang HS]]
-	~~[[Category: Cholesterol]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: Lipid transfer]]~~	+
-	~~[[Category: Oxysterol binding~~]]	+

OCA at 07:18, 7 October 2020

OCA — Wed, 07 Oct 2020 07:18:27 GMT

←Older revision		Revision as of 07:18, 7 October 2020
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	==Crystal structure of Osh1 ORD domain in complex with cholesterol==		==Crystal structure of Osh1 ORD domain in complex with cholesterol==
-	<StructureSection load='5wvr' size='340' side='right' caption='[[5wvr]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5wvr' size='340' side='right'caption='[[5wvr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wvr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WVR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WVR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WVR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WVR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wvr OCA], [http://pdbe.org/5wvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wvr RCSB], [http://www.ebi.ac.uk/pdbsum/5wvr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wvr ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLLA0_C04147g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wvr OCA], [http://pdbe.org/5wvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wvr RCSB], [http://www.ebi.ac.uk/pdbsum/5wvr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wvr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5wvr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5wvr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Oxysterol-binding protein homolog\|Oxysterol-binding protein homolog]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Candida sphaerica]]
		+	[[Category: Large Structures]]
	[[Category: Im, Y J]]		[[Category: Im, Y J]]
	[[Category: Manik, M K]]		[[Category: Manik, M K]]

OCA at 12:47, 10 May 2017

OCA — Wed, 10 May 2017 12:47:17 GMT

←Older revision		Revision as of 12:47, 10 May 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5wvr is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Osh1 ORD domain in complex with cholesterol==
		+	<StructureSection load='5wvr' size='340' side='right' caption='[[5wvr]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wvr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WVR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wvr OCA], [http://pdbe.org/5wvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wvr RCSB], [http://www.ebi.ac.uk/pdbsum/5wvr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wvr ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Yeast Osh1 belongs to the oxysterol-binding protein (OSBP) family of proteins and contains multiple targeting modules optimized for lipid transport at the nucleus-vacuole junction (NVJ). The key determinants for NVJ targeting and the role of Osh1 at NVJs have remained elusive because of unknown lipid specificities. In this study, we determined the structures of the ankyrin repeat domain (ANK), and OSBP-related domain (ORD) of Osh1, in complex with Nvj1 and ergosterol, respectively. The Osh1 ANK forms a unique bi-lobed structure that recognizes a cytosolic helical segment of Nvj1. We discovered that Osh1 ORD binds ergosterol and phosphatidylinositol 4-phosphate PI(4)P in a competitive manner, suggesting counter-transport function of the two lipids. Ergosterol is bound to the hydrophobic pocket in a head-down orientation, and the structure of the PI(4)P-binding site in Osh1 is well conserved. Our results suggest that Osh1 performs non-vesicular transport of ergosterol and PI(4)P at the NVJ.

-	~~Authors~~:	+	Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction.,Manik MK, Yang H, Tong J, Im YJ Structure. 2017 Apr 4;25(4):617-629.e3. doi: 10.1016/j.str.2017.02.010. Epub 2017, Mar 16. PMID:28319008<ref>PMID:28319008</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5wvr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Im, Y J]]
		+	[[Category: Manik, M K]]
		+	[[Category: Tong, J S]]
		+	[[Category: Yang, H S]]
		+	[[Category: Cholesterol]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: Lipid transfer]]
		+	[[Category: Oxysterol binding]]

OCA at 15:14, 18 January 2017

OCA — Wed, 18 Jan 2017 15:14:46 GMT

←Older revision		Revision as of 15:14, 18 January 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wvr is ON HOLD	+	The entry 5wvr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5wvr" [edit=sysop:move=sysop]

OCA — Wed, 04 Jan 2017 15:56:39 GMT

Protected "5wvr" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:56, 4 January 2017

OCA: New page: '''Unreleased structure''' The entry 5wvr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Jan 2017 15:56:38 GMT

New page: '''Unreleased structure''' The entry 5wvr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wvr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]