5wwp - Revision history

OCA at 09:31, 15 September 2021

OCA — Wed, 15 Sep 2021 09:31:48 GMT

←Older revision		Revision as of 09:31, 15 September 2021
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	==Crystal structure of Middle East respiratory syndrome coronavirus helicase (MERS-CoV nsp13)==		==Crystal structure of Middle East respiratory syndrome coronavirus helicase (MERS-CoV nsp13)==
-	<StructureSection load='5wwp' size='340' side='right' caption='[[5wwp]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='5wwp' size='340' side='right'caption='[[5wwp]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wwp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WWP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wwp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WWP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">orf1ab ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1235996 Human betacoronavirus 2c EMC/2012])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">orf1ab ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1235996 Human betacoronavirus 2c EMC/2012])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwp OCA], [~~http~~://pdbe.org/5wwp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wwp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wwp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwp OCA], [https://pdbe.org/5wwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wwp RCSB], [https://www.ebi.ac.uk/pdbsum/5wwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Human betacoronavirus 2c emc/2012]]		[[Category: Human betacoronavirus 2c emc/2012]]
		+	[[Category: Large Structures]]
	[[Category: Cui, S]]		[[Category: Cui, S]]
	[[Category: Das, R]]		[[Category: Das, R]]

OCA at 06:48, 16 November 2017

OCA — Thu, 16 Nov 2017 06:48:37 GMT

←Older revision		Revision as of 06:48, 16 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wwp is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Middle East respiratory syndrome coronavirus helicase (MERS-CoV nsp13)==
		+	<StructureSection load='5wwp' size='340' side='right' caption='[[5wwp]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wwp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WWP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">orf1ab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1235996 Human betacoronavirus 2c EMC/2012])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwp OCA], [http://pdbe.org/5wwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wwp RCSB], [http://www.ebi.ac.uk/pdbsum/5wwp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwp ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Middle East respiratory syndrome coronavirus (MERS-CoV) remains a threat to public health worldwide; however, effective vaccine or drug against CoVs remains unavailable. CoV helicase is one of the three evolutionary most conserved proteins in nidoviruses, thus making it an important target for drug development. We report here the first structure of full-length coronavirus helicase, MERS-CoV nsp13. MERS-CoV helicase has multiple domains, including an N-terminal Cys/His rich domain (CH) with three zinc atoms, a beta-barrel domain and a C-terminal SF1 helicase core with two RecA-like subdomains. Our structural analyses show that while the domain organization of nsp13 is conserved throughout nidoviruses, the individual domains of nsp13 are closely related to the equivalent eukaryotic domains of Upf1 helicases. The most distinctive feature differentiating CoV helicases from eukaryotic Upf1 helicases is the interaction between CH domain and helicase core.

-	~~Authors~~:	+	Crystal structure of Middle East respiratory syndrome coronavirus helicase.,Hao W, Wojdyla JA, Zhao R, Han R, Das R, Zlatev I, Manoharan M, Wang M, Cui S PLoS Pathog. 2017 Jun 26;13(6):e1006474. doi: 10.1371/journal.ppat.1006474., eCollection 2017 Jun. PMID:28651017<ref>PMID:28651017</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5wwp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human betacoronavirus 2c emc/2012]]
		+	[[Category: Cui, S]]
		+	[[Category: Das, R]]
		+	[[Category: Han, R]]
		+	[[Category: Hao, W]]
		+	[[Category: Manoharan, M]]
		+	[[Category: Wang, M]]
		+	[[Category: Wojdyla, J A]]
		+	[[Category: Zhao, R]]
		+	[[Category: Zlatev, I]]
		+	[[Category: 1b beta-barrel domain]]
		+	[[Category: Arterivirus nsp10]]
		+	[[Category: Atp hydrolysis]]
		+	[[Category: Atpase]]
		+	[[Category: Ch domain]]
		+	[[Category: Coronavirus]]
		+	[[Category: Cov replication and transcription]]
		+	[[Category: Helicase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mer]]
		+	[[Category: Middle east respiratory syndrome coronavirus]]
		+	[[Category: Nidovirale]]
		+	[[Category: Nsp13]]
		+	[[Category: Reca-like domain]]
		+	[[Category: Rna 5'-triphosphatase]]
		+	[[Category: Sf1 superfamily]]
		+	[[Category: Unwinding]]
		+	[[Category: Upf1 helicase]]
		+	[[Category: Viral rna synthesis]]
		+	[[Category: Zinc binding domain]]

OCA at 15:25, 9 March 2017

OCA — Thu, 09 Mar 2017 15:25:42 GMT

←Older revision		Revision as of 15:25, 9 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wwp is ON HOLD	+	The entry 5wwp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5wwp" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 15:17:21 GMT

Protected "5wwp" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:17, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5wwp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jan 2017 15:17:20 GMT

New page: '''Unreleased structure''' The entry 5wwp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wwp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]