5wwq - Revision history

OCA at 07:49, 22 November 2023

OCA — Wed, 22 Nov 2023 07:49:59 GMT

←Older revision		Revision as of 07:49, 22 November 2023
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	==Crystal structure of human NSun6==		==Crystal structure of human NSun6==
-	<StructureSection load='5wwq' size='340' side='right' caption='[[5wwq]], [[Resolution\|resolution]] 2.81Å' scene=''>	+	<StructureSection load='5wwq' size='340' side='right'caption='[[5wwq]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wwq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WWQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wwq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WWQ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5wwr\|5wwr]], [[5wws\|5wws]], [[5wwt\|5wwt]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.815Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">NSUN6, NOPD1 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwq OCA], [https://pdbe.org/5wwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wwq RCSB], [https://www.ebi.ac.uk/pdbsum/5wwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwq OCA], [~~http~~://pdbe.org/5wwq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wwq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wwq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NSUN6_HUMAN NSUN6_HUMAN]] May have S-adenosyl-L-methionine-dependent methyl-transferase activity.	+	[https://www.uniprot.org/uniprot/NSUN6_HUMAN NSUN6_HUMAN] May have S-adenosyl-L-methionine-dependent methyl-transferase activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Liu, R J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Long, T~~]]	+	[[Category: Liu RJ]]
-	[[Category: ~~Wang, E D~~]]	+	[[Category: Long T]]
-	[[Category: ~~M5c methyltransferase]]~~	+	[[Category: Wang ED]]
-	~~[[Category: Nsun]]~~	+
-	~~[[Category: Rna modification]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:26, 6 November 2017

OCA — Mon, 06 Nov 2017 11:26:06 GMT

←Older revision		Revision as of 11:26, 6 November 2017
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	<StructureSection load='5wwq' size='340' side='right' caption='[[5wwq]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='5wwq' size='340' side='right' caption='[[5wwq]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wwq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WWQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wwq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WWQ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wwr\|5wwr]], [[5wws\|5wws]], [[5wwt\|5wwt]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wwr\|5wwr]], [[5wws\|5wws]], [[5wwt\|5wwt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NSUN6, NOPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwq OCA], [http://pdbe.org/5wwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wwq RCSB], [http://www.ebi.ac.uk/pdbsum/5wwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwq OCA], [http://pdbe.org/5wwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wwq RCSB], [http://www.ebi.ac.uk/pdbsum/5wwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwq ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Liu, R J]]		[[Category: Liu, R J]]
	[[Category: Long, T]]		[[Category: Long, T]]

OCA at 03:57, 30 August 2017

OCA — Wed, 30 Aug 2017 03:57:34 GMT

←Older revision		Revision as of 03:57, 30 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5wwq is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human NSun6==
		+	<StructureSection load='5wwq' size='340' side='right' caption='[[5wwq]], [[Resolution\|resolution]] 2.81Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wwq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WWQ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wwr\|5wwr]], [[5wws\|5wws]], [[5wwt\|5wwt]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wwq OCA], [http://pdbe.org/5wwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wwq RCSB], [http://www.ebi.ac.uk/pdbsum/5wwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wwq ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NSUN6_HUMAN NSUN6_HUMAN]] May have S-adenosyl-L-methionine-dependent methyl-transferase activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	5-methylcytosine (m5C) modifications of RNA are ubiquitous in nature and play important roles in many biological processes such as protein translational regulation, RNA processing and stress response. Aberrant expressions of RNA:m5C methyltransferases are closely associated with various human diseases including cancers. However, no structural information for RNA-bound RNA:m5C methyltransferase was available until now, hindering elucidation of the catalytic mechanism behind RNA:m5C methylation. Here, we have solved the structures of NSun6, a human tRNA:m5C methyltransferase, in the apo form and in complex with a full-length tRNA substrate. These structures show a non-canonical conformation of the bound tRNA, rendering the base moiety of the target cytosine accessible to the enzyme for methylation. Further biochemical assays reveal the critical, but distinct, roles of two conserved cysteine residues for the RNA:m5C methylation. Collectively, for the first time, we have solved the complex structure of a RNA:m5C methyltransferase and addressed the catalytic mechanism of the RNA:m5C methyltransferase family, which may allow for structure-based drug design toward RNA:m5C methyltransferase-related diseases.

-	~~Authors~~:	+	Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6.,Liu RJ, Long T, Li J, Li H, Wang ED Nucleic Acids Res. 2017 May 22. doi: 10.1093/nar/gkx473. PMID:28531330<ref>PMID:28531330</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5wwq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Liu, R J]]
		+	[[Category: Long, T]]
		+	[[Category: Wang, E D]]
		+	[[Category: M5c methyltransferase]]
		+	[[Category: Nsun]]
		+	[[Category: Rna modification]]
		+	[[Category: Transferase]]

OCA at 22:31, 25 January 2017

OCA — Wed, 25 Jan 2017 22:31:49 GMT

←Older revision		Revision as of 22:31, 25 January 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wwq is ON HOLD	+	The entry 5wwq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5wwq" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 15:17:25 GMT

Protected "5wwq" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:17, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5wwq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jan 2017 15:17:23 GMT

New page: '''Unreleased structure''' The entry 5wwq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wwq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]