5wxd - Revision history

OCA at 06:41, 31 July 2019

OCA — Wed, 31 Jul 2019 06:41:55 GMT

←Older revision		Revision as of 06:41, 31 July 2019
Line 1:		Line 1:

	==Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1)==		==Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1)==
-	<StructureSection load='5wxd' size='340' side='right' caption='[[5wxd]], [[Resolution\|resolution]] 3.29Å' scene=''>	+	<StructureSection load='5wxd' size='340' side='right'caption='[[5wxd]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wxd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WXD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wxd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WXD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wxc\|5wxc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wxc\|5wxc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wxd OCA], [http://pdbe.org/5wxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wxd RCSB], [http://www.ebi.ac.uk/pdbsum/5wxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wxd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wxd OCA], [http://pdbe.org/5wxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wxd RCSB], [http://www.ebi.ac.uk/pdbsum/5wxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wxd ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/1A24_HUMAN 1A24_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.		[[http://www.uniprot.org/uniprot/1A24_HUMAN 1A24_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Against a backdrop of seasonal influenza virus epidemics, emerging avian influenza viruses (AIVs) occasionally jump from birds to humans, posing a public health risk, especially with the recent sharp increase in H7N9 infections. Evaluations of cross-reactive T-cell immunity to seasonal influenza viruses and human-infecting AIVs have been reported previously. However, the roles of influenza A virus-derived epitopes in the cross-reactive T-cell responses and heterosubtypic protections are not well understood; understanding those roles is important for preventing and controlling new emerging AIVs. Here, among the members of a healthy population presumed to have previously been infected by pandemic H1N1 (pH1N1), we found that pH1N1-specific T cells showed cross- but biased reactivity to human-infecting AIVs, i.e., H5N1, H6N1, H7N9, and H9N2, which correlates with distinct protections. Through a T-cell epitope-based phylogenetic analysis, the cellular immunogenic clustering expanded the relevant conclusions to a broader range of virus strains. We defined the potential key conserved epitopes required for cross-protection and revealed the molecular basis for the immunogenic variations. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development.IMPORTANCE We revealed preexisting but biased T-cell reactivity of pH1N1 influenza virus to human-infecting AIVs, which provided distinct protections. The cross-reactive T-cell recognition had a regular pattern that depended on the T-cell epitope matrix revealed via bioinformatics analysis. Our study elucidated an overall profile of cross-reactivity to AIVs and provided useful recommendations for broad-spectrum vaccine development.
		+
		+	Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.,Zhao M, Liu K, Luo J, Tan S, Quan C, Zhang S, Chai Y, Qi J, Li Y, Bi Y, Xiao H, Wong G, Zhou J, Jiang T, Liu W, Yu H, Yan J, Liu Y, Shu Y, Wu G, Wu A, Gao GF, Liu WJ MBio. 2018 Aug 7;9(4). pii: mBio.01408-18. doi: 10.1128/mBio.01408-18. PMID:30087171<ref>PMID:30087171</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5wxd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chai, Y]]		[[Category: Chai, Y]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]

OCA at 06:56, 17 January 2018

OCA — Wed, 17 Jan 2018 06:56:25 GMT

←Older revision		Revision as of 06:56, 17 January 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5wxd is ON HOLD until Paper Publication~~	+	==Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1)==
-		+	<StructureSection load='5wxd' size='340' side='right' caption='[[5wxd]], [[Resolution\|resolution]] 3.29Å' scene=''>
-	~~Authors: Zhao, M., Liu, K., Chai, Y., Qi, J., Liu, J., Gao, G.F.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5wxd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WXD FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1)	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wxc\|5wxc]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wxd OCA], [http://pdbe.org/5wxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wxd RCSB], [http://www.ebi.ac.uk/pdbsum/5wxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wxd ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Gao~~, G.F]]	+	</table>
-	[[Category: ~~Zhao~~, M]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1A24_HUMAN 1A24_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chai, Y]]
		+	[[Category: Gao, G F]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
-	[[Category: Chai, Y]]
	[[Category: Liu, K]]		[[Category: Liu, K]]
	[[Category: Qi, J]]		[[Category: Qi, J]]
		+	[[Category: Zhao, M]]
		+	[[Category: H1-25]]
		+	[[Category: H1n1]]
		+	[[Category: H5n1]]
		+	[[Category: Hla-a*2402]]
		+	[[Category: Immune system]]

OCA at 15:10, 27 September 2017

OCA — Wed, 27 Sep 2017 15:10:15 GMT

←Older revision		Revision as of 15:10, 27 September 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Gao, G.F]]		[[Category: Gao, G.F]]
-	[[Category: Chai, Y]]
-	[[Category: Liu, K]]
	[[Category: Zhao, M]]		[[Category: Zhao, M]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
		+	[[Category: Chai, Y]]
		+	[[Category: Liu, K]]
	[[Category: Qi, J]]		[[Category: Qi, J]]

OCA at 12:04, 5 April 2017

OCA — Wed, 05 Apr 2017 12:04:48 GMT

←Older revision		Revision as of 12:04, 5 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wxd is ON HOLD	+	The entry 5wxd is ON HOLD until Paper Publication

	Authors: Zhao, M., Liu, K., Chai, Y., Qi, J., Liu, J., Gao, G.F.		Authors: Zhao, M., Liu, K., Chai, Y., Qi, J., Liu, J., Gao, G.F.

OCA at 19:57, 15 March 2017

OCA — Wed, 15 Mar 2017 19:57:22 GMT

←Older revision		Revision as of 19:57, 15 March 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Gao, G.F]]		[[Category: Gao, G.F]]
-	[[Category: Zhao, M]]
-	[[Category: Liu, J]]
	[[Category: Chai, Y]]		[[Category: Chai, Y]]
	[[Category: Liu, K]]		[[Category: Liu, K]]
		+	[[Category: Zhao, M]]
		+	[[Category: Liu, J]]
	[[Category: Qi, J]]		[[Category: Qi, J]]

OCA: Protected "5wxd" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 15:19:01 GMT

Protected "5wxd" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:19, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5wxd is ON HOLD Authors: Zhao, M., Liu, K., Chai, Y., Qi, J., Liu, J., Gao, G.F. Description: Crystal Structure of HLA-A*2402 in complex with avian...

OCA — Wed, 18 Jan 2017 15:19:00 GMT

New page: '''Unreleased structure''' The entry 5wxd is ON HOLD Authors: Zhao, M., Liu, K., Chai, Y., Qi, J., Liu, J., Gao, G.F. Description: Crystal Structure of HLA-A*2402 in complex with avian...

New page

'''Unreleased structure'''

The entry 5wxd is ON HOLD

Authors: Zhao, M., Liu, K., Chai, Y., Qi, J., Liu, J., Gao, G.F.

Description: Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1)
[[Category: Unreleased Structures]]
[[Category: Gao, G.F]]
[[Category: Zhao, M]]
[[Category: Liu, J]]
[[Category: Chai, Y]]
[[Category: Liu, K]]
[[Category: Qi, J]]