5wxg - Revision history

OCA at 07:19, 7 October 2020

OCA — Wed, 07 Oct 2020 07:19:18 GMT

←Older revision		Revision as of 07:19, 7 October 2020
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	==Structure of TAF PHD finger domain binds to H3(1-15)K4ac==		==Structure of TAF PHD finger domain binds to H3(1-15)K4ac==
-	<StructureSection load='5wxg' size='340' side='right' caption='[[5wxg]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='5wxg' size='340' side='right'caption='[[5wxg]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wxg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WXG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wxg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WXG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WXG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wxg OCA], [http://pdbe.org/5wxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wxg RCSB], [http://www.ebi.ac.uk/pdbsum/5wxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wxg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wxg OCA], [http://pdbe.org/5wxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wxg RCSB], [http://www.ebi.ac.uk/pdbsum/5wxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wxg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5wxg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5wxg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transcription initiation factors 3D structures\|Transcription initiation factors 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Zhao, S]]		[[Category: Zhao, S]]

OCA at 10:53, 13 September 2017

OCA — Wed, 13 Sep 2017 10:53:19 GMT

←Older revision		Revision as of 10:53, 13 September 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5wxg is ~~ON HOLD until Paper~~ Publication	+	==Structure of TAF PHD finger domain binds to H3(1-15)K4ac==
		+	<StructureSection load='5wxg' size='340' side='right' caption='[[5wxg]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wxg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WXG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wxg OCA], [http://pdbe.org/5wxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wxg RCSB], [http://www.ebi.ac.uk/pdbsum/5wxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wxg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TAF3_HUMAN TAF3_HUMAN]] Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chemical modifications on histones and DNA/RNA constitute a fundamental mechanism for epigenetic regulation. These modifications often function as docking marks to recruit or stabilize cognate "reader" proteins. So far, a platform for quantitative and high-throughput profiling of the epigenetic interactome is urgently needed but still lacking. Here, we report a 3D-carbene chip-based surface plasmon resonance imaging (SPRi) technology for this purpose. The 3D-carbene chip is suitable for immobilizing versatile biomolecules (e.g., peptides, antibody, DNA/RNA) and features low nonspecific binding, random yet function-retaining immobilization, and robustness for reuses. We systematically profiled binding kinetics of 1,000 histone "reader-mark" pairs on a single 3D-carbene chip and validated two recognition events by calorimetric and structural studies. Notably, a discovery on H3K4me3 recognition by the DNA mismatch repair protein MSH6 in Capsella rubella suggests a mechanism of H3K4me3-mediated DNA damage repair in plant.

-	~~Authors~~:	+	Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology.,Zhao S, Yang M, Zhou W, Zhang B, Cheng Z, Huang J, Zhang M, Wang Z, Wang R, Chen Z, Zhu J, Li H Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7245-E7254. doi:, 10.1073/pnas.1704155114. Epub 2017 Aug 14. PMID:28808021<ref>PMID:28808021</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5wxg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Li, H]]
		+	[[Category: Zhao, S]]
		+	[[Category: Histone h3]]
		+	[[Category: Hydrolase]]
		+	[[Category: Taf3]]

OCA at 22:33, 25 January 2017

OCA — Wed, 25 Jan 2017 22:33:12 GMT

←Older revision		Revision as of 22:33, 25 January 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5wxg is ON HOLD	+	The entry 5wxg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5wxg" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 15:19:14 GMT

Protected "5wxg" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:19, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5wxg is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jan 2017 15:19:13 GMT

New page: '''Unreleased structure''' The entry 5wxg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wxg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]