5wy9 - Revision history

OCA at 07:51, 22 November 2023

OCA — Wed, 22 Nov 2023 07:51:28 GMT

←Older revision		Revision as of 07:51, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5wy9' size='340' side='right'caption='[[5wy9]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5wy9' size='340' side='right'caption='[[5wy9]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wy9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5WY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WY9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTGDS, PDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy9 OCA], [https://pdbe.org/5wy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wy9 RCSB], [https://www.ebi.ac.uk/pdbsum/5wy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5wy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy9 OCA], [~~http~~://pdbe.org/5wy9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wy9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wy9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>	+	[https://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>

	==See Also==		==See Also==
Line 18:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Prostaglandin-D synthase]]~~	+	[[Category: Pervushin K]]
-	[[Category: Pervushin, K]]	+	[[Category: Saif M]]
-	[[Category: Saif, M]]	+
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Synthetase~~]]	+

OCA at 07:19, 7 October 2020

OCA — Wed, 07 Oct 2020 07:19:56 GMT

←Older revision		Revision as of 07:19, 7 October 2020
Line 1:		Line 1:

	==Apo form crystal structure of human Lipocalin PGDS .==		==Apo form crystal structure of human Lipocalin PGDS .==
-	<StructureSection load='5wy9' size='340' side='right' caption='[[5wy9]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='5wy9' size='340' side='right'caption='[[5wy9]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WY9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTGDS, PDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy9 OCA], [http://pdbe.org/5wy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wy9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy9 OCA], [http://pdbe.org/5wy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wy9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>		[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>
		+
		+	==See Also==
		+	*[[Prostaglandin D synthase\|Prostaglandin D synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Prostaglandin-D synthase]]		[[Category: Prostaglandin-D synthase]]
	[[Category: Pervushin, K]]		[[Category: Pervushin, K]]

OCA at 23:49, 25 January 2017

OCA — Wed, 25 Jan 2017 23:49:43 GMT

←Older revision		Revision as of 23:49, 25 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wy9 is ~~ON HOLD~~	+	==Apo form crystal structure of human Lipocalin PGDS .==
-		+	<StructureSection load='5wy9' size='340' side='right' caption='[[5wy9]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~Authors~~: ~~Saif~~, M., ~~Pervushin~~, K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5wy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WY9 FirstGlance]. <br>
-	~~Description~~: ~~Apo form crystal structure~~ of ~~human Lipocalin PGDS~~ .	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy9 OCA], [http://pdbe.org/5wy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wy9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Prostaglandin-D synthase]]
	[[Category: Pervushin, K]]		[[Category: Pervushin, K]]
	[[Category: Saif, M]]		[[Category: Saif, M]]
		+	[[Category: Beta barrel]]
		+	[[Category: Chaperone]]
		+	[[Category: Synthetase]]

OCA: Protected "5wy9" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 15:21:02 GMT

Protected "5wy9" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:21, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5wy9 is ON HOLD Authors: Saif, M., Pervushin, K. Description: Apo form crystal structure of human Lipocalin PGDS . [[Category: Unreleased Structure...

OCA — Wed, 18 Jan 2017 15:21:01 GMT

New page: '''Unreleased structure''' The entry 5wy9 is ON HOLD Authors: Saif, M., Pervushin, K. Description: Apo form crystal structure of human Lipocalin PGDS . [[Category: Unreleased Structure...

New page

'''Unreleased structure'''

The entry 5wy9 is ON HOLD

Authors: Saif, M., Pervushin, K.

Description: Apo form crystal structure of human Lipocalin PGDS .
[[Category: Unreleased Structures]]
[[Category: Pervushin, K]]
[[Category: Saif, M]]