5x1u - Revision history

OCA at 06:20, 20 June 2018

OCA — Wed, 20 Jun 2018 06:20:07 GMT

←Older revision		Revision as of 06:20, 20 June 2018
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	<StructureSection load='5x1u' size='340' side='right' caption='[[5x1u]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5x1u' size='340' side='right' caption='[[5x1u]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x1u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X1U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x1u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legpl Legpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X1U FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x1h\|5x1h]], [[5x1e\|5x1e]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x1h\|5x1h]], [[5x1e\|5x1e]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dotM, icmP, lpl0487 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=297245 LEGPL])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x1u OCA], [http://pdbe.org/5x1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x1u RCSB], [http://www.ebi.ac.uk/pdbsum/5x1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x1u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x1u OCA], [http://pdbe.org/5x1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x1u RCSB], [http://www.ebi.ac.uk/pdbsum/5x1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x1u ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Legpl]]
	[[Category: Kim, Y G]]		[[Category: Kim, Y G]]
	[[Category: Kwak, M J]]		[[Category: Kwak, M J]]

OCA at 04:16, 4 August 2017

OCA — Fri, 04 Aug 2017 04:16:03 GMT

←Older revision		Revision as of 04:16, 4 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5x1u is ~~ON HOLD until Paper~~ Publication	+	==Structure of the cytosolic domain of DotM derived from Legionella pneumophila==
		+	<StructureSection load='5x1u' size='340' side='right' caption='[[5x1u]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5x1u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X1U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X1U FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x1h\|5x1h]], [[5x1e\|5x1e]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x1u OCA], [http://pdbe.org/5x1u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x1u RCSB], [http://www.ebi.ac.uk/pdbsum/5x1u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x1u ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many bacteria, including Legionella pneumophila, rely on the type IV secretion system to translocate a repertoire of effector proteins into the hosts for their survival and growth. Type IV coupling protein (T4CP) is a hexameric ATPase that links translocating substrates to the transenvelope secretion conduit. Yet, how a large number of effector proteins are selectively recruited and processed by T4CPs remains enigmatic. DotL, the T4CP of L. pneumophila, contains an ATPase domain and a C-terminal extension whose function is unknown. Unlike T4CPs involved in plasmid DNA translocation, DotL appeared to function by forming a multiprotein complex with four other proteins. Here, we show that the C-terminal extension of DotL interacts with DotN, IcmS, IcmW and an additionally identified subunit LvgA, and that this pentameric assembly binds Legionella effector proteins. We determined the crystal structure of this assembly and built an architecture of the T4CP holocomplex by combining a homology model of the ATPase domain of DotL. The holocomplex is a hexamer of a bipartite structure composed of a membrane-proximal ATPase domain and a membrane-distal substrate-recognition assembly. The presented information demonstrates the architecture and functional dissection of the multiprotein T4CP complexes and provides important insights into their substrate recruitment and processing.

-	~~Authors~~:	+	Architecture of the type IV coupling protein complex of Legionella pneumophila.,Kwak MJ, Kim JD, Kim H, Kim C, Bowman JW, Kim S, Joo K, Lee J, Jin KS, Kim YG, Lee NK, Jung JU, Oh BH Nat Microbiol. 2017 Jul 17;2:17114. doi: 10.1038/nmicrobiol.2017.114. PMID:28714967<ref>PMID:28714967</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5x1u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kim, Y G]]
		+	[[Category: Kwak, M J]]
		+	[[Category: Oh, B H]]
		+	[[Category: Coupling protein complex]]
		+	[[Category: Effector translocation]]
		+	[[Category: Protein transport]]
		+	[[Category: Type iv secretion system]]

OCA at 12:11, 5 April 2017

OCA — Wed, 05 Apr 2017 12:11:39 GMT

←Older revision		Revision as of 12:11, 5 April 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5x1u is ON HOLD	+	The entry 5x1u is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5x1u" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 15:35:34 GMT

Protected "5x1u" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:35, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x1u is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 09 Mar 2017 15:35:33 GMT

New page: '''Unreleased structure''' The entry 5x1u is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5x1u is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]