5x4r - Revision history

OCA at 07:25, 7 October 2020

OCA — Wed, 07 Oct 2020 07:25:19 GMT

←Older revision		Revision as of 07:25, 7 October 2020
Line 1:		Line 1:

	==Structure of the N-terminal domain (NTD) of MERS-CoV spike protein==		==Structure of the N-terminal domain (NTD) of MERS-CoV spike protein==
-	<StructureSection load='5x4r' size='340' side='right' caption='[[5x4r]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5x4r' size='340' side='right'caption='[[5x4r]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x4r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X4R OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5X4R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x4r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X4R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X4R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x4s\|5x4s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x4s\|5x4s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x4r OCA], [http://pdbe.org/5x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x4r RCSB], [http://www.ebi.ac.uk/pdbsum/5x4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x4r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x4r OCA], [http://pdbe.org/5x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x4r RCSB], [http://www.ebi.ac.uk/pdbsum/5x4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x4r ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5x4r" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5x4r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sandbox 3001\|Sandbox 3001]]
		+	*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mers]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]
	[[Category: Qi, J]]		[[Category: Qi, J]]

OCA at 13:04, 4 May 2017

OCA — Thu, 04 May 2017 13:04:11 GMT

←Older revision		Revision as of 13:04, 4 May 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5x4r is ~~ON HOLD until Paper~~ Publication	+	==Structure of the N-terminal domain (NTD) of MERS-CoV spike protein==
		+	<StructureSection load='5x4r' size='340' side='right' caption='[[5x4r]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5x4r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X4R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x4s\|5x4s]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x4r OCA], [http://pdbe.org/5x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x4r RCSB], [http://www.ebi.ac.uk/pdbsum/5x4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x4r ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics. Here, we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle cryo-electron microscopy. The overall structures resemble that from other coronaviruses including HKU1, MHV and NL63 reported recently, with the exception of the receptor binding domain (RBD). We captured two states of the RBD with receptor binding region either buried (lying state) or exposed (standing state), demonstrating an inherently flexible RBD readily recognized by the receptor. Further sequence conservation analysis of six human-infecting coronaviruses revealed that the fusion peptide, HR1 region and the central helix are potential targets for eliciting broadly neutralizing antibodies.

-	~~Authors~~:	+	Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains.,Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF Nat Commun. 2017 Apr 10;8:15092. doi: 10.1038/ncomms15092. PMID:28393837<ref>PMID:28393837</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5x4r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gao, G F]]
		+	[[Category: Qi, J]]
		+	[[Category: Shi, Y]]
		+	[[Category: Yuan, Y]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Mers-cov]]
		+	[[Category: N-terminal domain]]
		+	[[Category: Spike]]
		+	[[Category: Viral protein]]

OCA: Protected "5x4r" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 15:45:05 GMT

Protected "5x4r" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:45, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x4r is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Thu, 09 Mar 2017 15:45:04 GMT

New page: '''Unreleased structure''' The entry 5x4r is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5x4r is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]