5x57 - Revision history

OCA at 10:17, 27 March 2024

OCA — Wed, 27 Mar 2024 10:17:20 GMT

←Older revision		Revision as of 10:17, 27 March 2024
Line 3:		Line 3:
	<StructureSection load='5x57' size='340' side='right'caption='[[5x57]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5x57' size='340' side='right'caption='[[5x57]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x57]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X57 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5X57 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X57 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5x57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x57 OCA], [~~http~~://pdbe.org/5x57 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5x57 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5x57 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5x57 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x57 OCA], [https://pdbe.org/5x57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x57 RCSB], [https://www.ebi.ac.uk/pdbsum/5x57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x57 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MACF1_HUMAN MACF1_HUMAN]] Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity).<ref>PMID:15265687</ref> <ref>PMID:20937854</ref>	+	[https://www.uniprot.org/uniprot/MACF1_HUMAN MACF1_HUMAN] Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity).<ref>PMID:15265687</ref> <ref>PMID:20937854</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	In the intestinal epithelium, the aberrant regulation of cell/cell junctions leads to intestinal barrier defects, which may promote the onset and enhance the severity of inflammatory bowel disease (IBD). However, it remains unclear how the coordinated behaviour of cytoskeletal network may contribute to cell junctional dynamics. In this report, we identified ACF7, a crosslinker of microtubules and F-actin, as an essential player in this process. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. With the mouse genetics approach, we show that ablation of ACF7 inhibits intestinal wound healing and greatly increases susceptibility to experimental colitis in mice. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in human patients. Together, our results reveal an important molecular mechanism whereby coordinated cytoskeletal dynamics contributes to cell adhesion regulation during intestinal wound repair and the development of IBD.	+
-		+
-	ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.,Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X Nat Commun. 2017 May 25;8:15375. doi: 10.1038/ncomms15375. PMID:28541346<ref>PMID:28541346</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 5x57" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wang, T]]	+	[[Category: Wang T]]
-	[[Category: Wu~~, X Y~~]]	+	[[Category: Wu XY]]
-	[[Category: Yang, F]]	+	[[Category: Yang F]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Functional class]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:26, 7 October 2020

OCA — Wed, 07 Oct 2020 07:26:11 GMT

←Older revision		Revision as of 07:26, 7 October 2020
Line 1:		Line 1:

	==Structure of GAR domain of ACF7==		==Structure of GAR domain of ACF7==
-	<StructureSection load='5x57' size='340' side='right' caption='[[5x57]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='5x57' size='340' side='right'caption='[[5x57]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x57]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X57 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5X57 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x57]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X57 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X57 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5x57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x57 OCA], [http://pdbe.org/5x57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x57 RCSB], [http://www.ebi.ac.uk/pdbsum/5x57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x57 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x57 OCA], [http://pdbe.org/5x57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x57 RCSB], [http://www.ebi.ac.uk/pdbsum/5x57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x57 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Wang, T]]		[[Category: Wang, T]]
	[[Category: Wu, X Y]]		[[Category: Wu, X Y]]

OCA at 03:40, 6 September 2017

OCA — Wed, 06 Sep 2017 03:40:23 GMT

←Older revision		Revision as of 03:40, 6 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5x57 is ~~ON HOLD~~	+	==Structure of GAR domain of ACF7==
		+	<StructureSection load='5x57' size='340' side='right' caption='[[5x57]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5x57]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X57 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x57 OCA], [http://pdbe.org/5x57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x57 RCSB], [http://www.ebi.ac.uk/pdbsum/5x57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x57 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MACF1_HUMAN MACF1_HUMAN]] Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity).<ref>PMID:15265687</ref> <ref>PMID:20937854</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the intestinal epithelium, the aberrant regulation of cell/cell junctions leads to intestinal barrier defects, which may promote the onset and enhance the severity of inflammatory bowel disease (IBD). However, it remains unclear how the coordinated behaviour of cytoskeletal network may contribute to cell junctional dynamics. In this report, we identified ACF7, a crosslinker of microtubules and F-actin, as an essential player in this process. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. With the mouse genetics approach, we show that ablation of ACF7 inhibits intestinal wound healing and greatly increases susceptibility to experimental colitis in mice. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in human patients. Together, our results reveal an important molecular mechanism whereby coordinated cytoskeletal dynamics contributes to cell adhesion regulation during intestinal wound repair and the development of IBD.

-	~~Authors: Yang, F~~., ~~Wang~~, T., Zhang, Y., Wu, X.Y.	+	ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.,Ma Y, Yue J, Zhang Y, Shi C, Odenwald M, Liang WG, Wei Q, Goel A, Gou X, Zhang J, Chen SY, Tang WJ, Turner JR, Yang F, Liang H, Qin H, Wu X Nat Commun. 2017 May 25;8:15375. doi: 10.1038/ncomms15375. PMID:28541346<ref>PMID:28541346</ref>

-	~~Description: Structure~~ of ~~GAR domain~~ of ~~ACF7~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5x57" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Wang, T]]		[[Category: Wang, T]]
-	[[Category: Wu, X~~.Y]]~~	+	[[Category: Wu, X Y]]
-	~~[[Category: Zhang,~~ Y]]	+
	[[Category: Yang, F]]		[[Category: Yang, F]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Functional class]]
		+	[[Category: Signaling protein]]

OCA at 20:11, 15 March 2017

OCA — Wed, 15 Mar 2017 20:11:42 GMT

←Older revision		Revision as of 20:11, 15 March 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Wang, T]]		[[Category: Wang, T]]
-	[[Category: Zhang, Y]]
	[[Category: Wu, X.Y]]		[[Category: Wu, X.Y]]
		+	[[Category: Zhang, Y]]
	[[Category: Yang, F]]		[[Category: Yang, F]]

OCA: Protected "5x57" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 15:45:58 GMT

Protected "5x57" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:45, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x57 is ON HOLD Authors: Yang, F., Wang, T., Zhang, Y., Wu, X.Y. Description: Structure of GAR domain of ACF7 Category: Unreleased Structures [...

OCA — Thu, 09 Mar 2017 15:45:57 GMT

New page: '''Unreleased structure''' The entry 5x57 is ON HOLD Authors: Yang, F., Wang, T., Zhang, Y., Wu, X.Y. Description: Structure of GAR domain of ACF7 Category: Unreleased Structures [...

New page

'''Unreleased structure'''

The entry 5x57 is ON HOLD

Authors: Yang, F., Wang, T., Zhang, Y., Wu, X.Y.

Description: Structure of GAR domain of ACF7
[[Category: Unreleased Structures]]
[[Category: Wang, T]]
[[Category: Zhang, Y]]
[[Category: Wu, X.Y]]
[[Category: Yang, F]]