5x5c - Revision history

OCA at 22:32, 10 April 2020

OCA — Fri, 10 Apr 2020 22:32:00 GMT

←Older revision		Revision as of 22:32, 10 April 2020
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	<SX load='5x5c' size='340' side='right' viewer='molstar' caption='[[5x5c]], [[Resolution\|resolution]] 4.10Å' scene=''>		<SX load='5x5c' size='340' side='right' viewer='molstar' caption='[[5x5c]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x5c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X5C OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5X5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x5c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X5C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X5C FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x59\|5x59]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x59\|5x59]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5x5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x5c OCA], [http://pdbe.org/5x5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x5c RCSB], [http://www.ebi.ac.uk/pdbsum/5x5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x5c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x5c OCA], [http://pdbe.org/5x5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x5c RCSB], [http://www.ebi.ac.uk/pdbsum/5x5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x5c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5x5c" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5x5c" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:09, 6 March 2020

OCA — Fri, 06 Mar 2020 20:09:12 GMT

←Older revision		Revision as of 20:09, 6 March 2020
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	==Prefusion structure of MERS-CoV spike glycoprotein, conformation 1==		==Prefusion structure of MERS-CoV spike glycoprotein, conformation 1==
-	<~~StructureSection~~ load='5x5c' size='340' side='right' caption='[[5x5c]], [[Resolution\|resolution]] 4.10Å' scene=''>	+	<SX load='5x5c' size='340' side='right' viewer='molstar' caption='[[5x5c]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x5c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x5c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X5C FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x59\|5x59]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x59\|5x59]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x5c OCA], [http://pdbe.org/5x5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x5c RCSB], [http://www.ebi.ac.uk/pdbsum/5x5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x5c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x5c OCA], [http://pdbe.org/5x5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x5c RCSB], [http://www.ebi.ac.uk/pdbsum/5x5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x5c ProSAT]</span></td></tr>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
		+	[[Category: Mers]]
	[[Category: Cao, D]]		[[Category: Cao, D]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]

OCA at 07:24, 24 May 2017

OCA — Wed, 24 May 2017 07:24:14 GMT

←Older revision		Revision as of 07:24, 24 May 2017
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	==Prefusion structure of MERS-CoV spike glycoprotein, conformation 1==		==Prefusion structure of MERS-CoV spike glycoprotein, conformation 1==
-	<StructureSection load='5x5c' size='340' side='right' caption='[[5x5c]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='5x5c' size='340' side='right' caption='[[5x5c]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5x5c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X5C FirstGlance]. <br>		<table><tr><td colspan='2'>[[5x5c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X5C FirstGlance]. <br>

OCA at 13:05, 4 May 2017

OCA — Thu, 04 May 2017 13:05:37 GMT

←Older revision		Revision as of 13:05, 4 May 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5x5c is ~~ON HOLD~~	+	==Prefusion structure of MERS-CoV spike glycoprotein, conformation 1==
		+	<StructureSection load='5x5c' size='340' side='right' caption='[[5x5c]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5x5c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X5C FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x59\|5x59]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x5c OCA], [http://pdbe.org/5x5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x5c RCSB], [http://www.ebi.ac.uk/pdbsum/5x5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x5c ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics. Here, we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle cryo-electron microscopy. The overall structures resemble that from other coronaviruses including HKU1, MHV and NL63 reported recently, with the exception of the receptor binding domain (RBD). We captured two states of the RBD with receptor binding region either buried (lying state) or exposed (standing state), demonstrating an inherently flexible RBD readily recognized by the receptor. Further sequence conservation analysis of six human-infecting coronaviruses revealed that the fusion peptide, HR1 region and the central helix are potential targets for eliciting broadly neutralizing antibodies.

-	~~Authors~~:	+	Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains.,Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF Nat Commun. 2017 Apr 10;8:15092. doi: 10.1038/ncomms15092. PMID:28393837<ref>PMID:28393837</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5x5c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cao, D]]
		+	[[Category: Gao, G F]]
		+	[[Category: Lu, G]]
		+	[[Category: Ma, J]]
		+	[[Category: Qi, J]]
		+	[[Category: Shi, Y]]
		+	[[Category: Wang, Q]]
		+	[[Category: Wu, Y]]
		+	[[Category: Yan, J]]
		+	[[Category: Yuan, Y]]
		+	[[Category: Zhang, X]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Mers-cov]]
		+	[[Category: Prefusion]]
		+	[[Category: Single particle]]
		+	[[Category: Spike glycoprotein]]
		+	[[Category: Viral protein]]

OCA at 10:25, 12 April 2017

OCA — Wed, 12 Apr 2017 10:25:09 GMT

←Older revision		Revision as of 10:25, 12 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5x5c is ON HOLD ~~until sometime in the future~~	+	The entry 5x5c is ON HOLD

	Authors:		Authors:

OCA at 12:16, 5 April 2017

OCA — Wed, 05 Apr 2017 12:16:36 GMT

←Older revision		Revision as of 12:16, 5 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5x5c is ON HOLD	+	The entry 5x5c is ON HOLD until sometime in the future

	Authors:		Authors:

OCA: Protected "5x5c" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 15:46:15 GMT

Protected "5x5c" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:46, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x5c is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 09 Mar 2017 15:46:14 GMT

New page: '''Unreleased structure''' The entry 5x5c is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5x5c is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]