5x83 - Revision history

OCA at 10:17, 27 March 2024

OCA — Wed, 27 Mar 2024 10:17:32 GMT

←Older revision		Revision as of 10:17, 27 March 2024
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	==Structure of DCC FN456 domains==		==Structure of DCC FN456 domains==
-	<StructureSection load='5x83' size='340' side='right' caption='[[5x83]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='5x83' size='340' side='right'caption='[[5x83]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x83]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X83 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5X83 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X83 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~DCC~~, ~~IGDCC1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.997Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x83 OCA], [~~http~~://pdbe.org/5x83 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5x83 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5x83 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5x83 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x83 OCA], [https://pdbe.org/5x83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x83 RCSB], [https://www.ebi.ac.uk/pdbsum/5x83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x83 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[~~http~~://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>	+	[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[https://omim.org/entry/157600 157600]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>	+	[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
		+
		+	==See Also==
		+	*[[Netrin receptor\|Netrin receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Finci, F I~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Wang, J~~]]	+	[[Category: Finci FI]]
-	[[Category: ~~Xiao,~~ J]]	+	[[Category: Wang J]]
-	[[Category: ~~Axon guidance]]~~	+	[[Category: Xiao J]]
-	~~[[Category: Dcc]]~~	+
-	~~[[Category: Netrin-1]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:37, 13 December 2017

OCA — Wed, 13 Dec 2017 07:37:17 GMT

←Older revision		Revision as of 07:37, 13 December 2017
Line 3:		Line 3:
	<StructureSection load='5x83' size='340' side='right' caption='[[5x83]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5x83' size='340' side='right' caption='[[5x83]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x83]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X83 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x83]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X83 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x83 OCA], [http://pdbe.org/5x83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x83 RCSB], [http://www.ebi.ac.uk/pdbsum/5x83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x83 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DCC, IGDCC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x83 OCA], [http://pdbe.org/5x83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x83 RCSB], [http://www.ebi.ac.uk/pdbsum/5x83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x83 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Finci, F I]]		[[Category: Finci, F I]]
	[[Category: Wang, J]]		[[Category: Wang, J]]

OCA at 03:47, 6 September 2017

OCA — Wed, 06 Sep 2017 03:47:56 GMT

←Older revision		Revision as of 03:47, 6 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5x83 is ~~ON HOLD~~	+	==Structure of DCC FN456 domains==
-		+	<StructureSection load='5x83' size='340' side='right' caption='[[5x83]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5x83]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X83 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x83 OCA], [http://pdbe.org/5x83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x83 RCSB], [http://www.ebi.ac.uk/pdbsum/5x83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x83 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Finci, F I]]
		+	[[Category: Wang, J]]
		+	[[Category: Xiao, J]]
		+	[[Category: Axon guidance]]
		+	[[Category: Dcc]]
		+	[[Category: Netrin-1]]
		+	[[Category: Signaling protein]]

OCA: Protected "5x83" [edit=sysop:move=sysop]

OCA — Thu, 09 Mar 2017 15:52:47 GMT

Protected "5x83" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:52, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x83 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 09 Mar 2017 15:52:46 GMT

New page: '''Unreleased structure''' The entry 5x83 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5x83 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]