5x9z - Revision history

OCA at 07:57, 22 November 2023

OCA — Wed, 22 Nov 2023 07:57:17 GMT

←Older revision		Revision as of 07:57, 22 November 2023
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	<StructureSection load='5x9z' size='340' side='right'caption='[[5x9z]], [[Resolution\|resolution]] 7.31Å' scene=''>		<StructureSection load='5x9z' size='340' side='right'caption='[[5x9z]], [[Resolution\|resolution]] 7.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x9z]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X9Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5X9Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X9Z FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5xa0\|5xa0]], [[5xa1\|5xa1]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 7.311Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Itpr1, Insp3r, Pcd6, Pcp1 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x9z OCA], [https://pdbe.org/5x9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x9z RCSB], [https://www.ebi.ac.uk/pdbsum/5x9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x9z ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5x9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x9z OCA], [~~http~~://pdbe.org/5x9z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5x9z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5x9z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5x9z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>	+	[https://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hamada, K]]	+	[[Category: Hamada K]]
-	[[Category: Mikoshiba, K]]	+	[[Category: Mikoshiba K]]
-	[[Category: Miyatake, H]]	+	[[Category: Miyatake H]]
-	[[Category: Terauchi, A]]	+	[[Category: Terauchi A]]
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Receptor channel calcium~~]]	+

OCA at 07:30, 7 October 2020

OCA — Wed, 07 Oct 2020 07:30:22 GMT

←Older revision		Revision as of 07:30, 7 October 2020
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	==Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain==		==Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain==
-	<StructureSection load='5x9z' size='340' side='right' caption='[[5x9z]], [[Resolution\|resolution]] 7.31Å' scene=''>	+	<StructureSection load='5x9z' size='340' side='right'caption='[[5x9z]], [[Resolution\|resolution]] 7.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x9z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X9Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5X9Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x9z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X9Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X9Z FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xa0\|5xa0]], [[5xa1\|5xa1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xa0\|5xa0]], [[5xa1\|5xa1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5x9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x9z OCA], [http://pdbe.org/5x9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x9z RCSB], [http://www.ebi.ac.uk/pdbsum/5x9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x9z ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Itpr1, Insp3r, Pcd6, Pcp1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x9z OCA], [http://pdbe.org/5x9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x9z RCSB], [http://www.ebi.ac.uk/pdbsum/5x9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x9z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5x9z" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5x9z" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Inositol 1%2C4%2C5-Trisphosphate Receptor\|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Hamada, K]]		[[Category: Hamada, K]]
	[[Category: Mikoshiba, K]]		[[Category: Mikoshiba, K]]

OCA at 09:07, 17 May 2017

OCA — Wed, 17 May 2017 09:07:49 GMT

←Older revision		Revision as of 09:07, 17 May 2017
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>		[[http://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is an IP3-gated ion channel that releases calcium ions (Ca2+) from the endoplasmic reticulum. The IP3-binding sites in the large cytosolic domain are distant from the Ca2+ conducting pore, and the allosteric mechanism of how IP3 opens the Ca2+ channel remains elusive. Here, we identify a long-range gating mechanism uncovered by channel mutagenesis and X-ray crystallography of the large cytosolic domain of mouse type 1 IP3R in the absence and presence of IP3 Analyses of two distinct space group crystals uncovered an IP3-dependent global translocation of the curvature alpha-helical domain interfacing with the cytosolic and channel domains. Mutagenesis of the IP3R channel revealed an essential role of a leaflet structure in the alpha-helical domain. These results suggest that the curvature alpha-helical domain relays IP3-controlled global conformational dynamics to the channel through the leaflet, conferring long-range allosteric coupling from IP3 binding to the Ca2+ channel.
		+
		+	IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography.,Hamada K, Miyatake H, Terauchi A, Mikoshiba K Proc Natl Acad Sci U S A. 2017 May 2;114(18):4661-4666. doi:, 10.1073/pnas.1701420114. Epub 2017 Apr 17. PMID:28416699<ref>PMID:28416699</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5x9z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:06, 19 April 2017

OCA — Wed, 19 Apr 2017 13:06:30 GMT

←Older revision		Revision as of 13:06, 19 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5x9z is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain==
-		+	<StructureSection load='5x9z' size='340' side='right' caption='[[5x9z]], [[Resolution\|resolution]] 7.31Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5x9z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X9Z FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xa0\|5xa0]], [[5xa1\|5xa1]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x9z OCA], [http://pdbe.org/5x9z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x9z RCSB], [http://www.ebi.ac.uk/pdbsum/5x9z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x9z ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hamada, K]]
		+	[[Category: Mikoshiba, K]]
		+	[[Category: Miyatake, H]]
		+	[[Category: Terauchi, A]]
		+	[[Category: Metal transport]]
		+	[[Category: Receptor channel calcium]]

OCA at 12:24, 5 April 2017

OCA — Wed, 05 Apr 2017 12:24:04 GMT

←Older revision		Revision as of 12:24, 5 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5x9z is ON HOLD	+	The entry 5x9z is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5x9z" [edit=sysop:move=sysop]

OCA — Wed, 15 Mar 2017 20:21:52 GMT

Protected "5x9z" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:21, 15 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x9z is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Mar 2017 20:21:51 GMT

New page: '''Unreleased structure''' The entry 5x9z is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5x9z is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]