5xdi - Revision history

OCA at 10:30, 14 June 2023

OCA — Wed, 14 Jun 2023 10:30:36 GMT

←Older revision		Revision as of 10:30, 14 June 2023
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	==Vaccatide: Antifungal Glutamine-rich 8C-Hevein-like Peptide, vH1==		==Vaccatide: Antifungal Glutamine-rich 8C-Hevein-like Peptide, vH1==
-	<StructureSection load='5xdi' size='340' side='right'caption='[[5xdi~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5xdi' size='340' side='right'caption='[[5xdi]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xdi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vaccaria_hispanica Vaccaria hispanica~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XDI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xdi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gypsophila_vaccaria Gypsophila vaccaria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XDI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdi OCA], [~~http~~://pdbe.org/5xdi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xdi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xdi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdi ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdi OCA], [https://pdbe.org/5xdi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xdi RCSB], [https://www.ebi.ac.uk/pdbsum/5xdi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2D0TCI2_GYPVA A0A2D0TCI2_GYPVA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Gypsophila vaccaria]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Vaccaria hispanica]]~~	+	[[Category: Tam JP]]
-	[[Category: Tam~~, J P~~]]	+	[[Category: Xiao T]]
-	[[Category: Xiao, T]]	+
-	~~[[Category: Antifungal]]~~	+
-	~~[[Category: Antifungal protein]]~~	+
-	~~[[Category: Cystein]]~~	+
-	~~[[Category: Hevein-like peptide~~]]	+

OCA at 06:46, 14 October 2020

OCA — Wed, 14 Oct 2020 06:46:43 GMT

←Older revision		Revision as of 06:46, 14 October 2020
Line 1:		Line 1:

	==Vaccatide: Antifungal Glutamine-rich 8C-Hevein-like Peptide, vH1==		==Vaccatide: Antifungal Glutamine-rich 8C-Hevein-like Peptide, vH1==
-	<StructureSection load='5xdi' size='340' side='right' caption='[[5xdi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5xdi' size='340' side='right'caption='[[5xdi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xdi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccaria_hispanica Vaccaria hispanica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XDI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xdi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccaria_hispanica Vaccaria hispanica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XDI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdi OCA], [http://pdbe.org/5xdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xdi RCSB], [http://www.ebi.ac.uk/pdbsum/5xdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdi ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdi OCA], [http://pdbe.org/5xdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xdi RCSB], [http://www.ebi.ac.uk/pdbsum/5xdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdi ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Vaccaria hispanica]]		[[Category: Vaccaria hispanica]]
	[[Category: Tam, J P]]		[[Category: Tam, J P]]

OCA at 16:23, 20 October 2017

OCA — Fri, 20 Oct 2017 16:23:37 GMT

←Older revision		Revision as of 16:23, 20 October 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5xdi is ~~ON HOLD~~	+	==Vaccatide: Antifungal Glutamine-rich 8C-Hevein-like Peptide, vH1==
		+	<StructureSection load='5xdi' size='340' side='right' caption='[[5xdi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xdi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccaria_hispanica Vaccaria hispanica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XDI FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdi OCA], [http://pdbe.org/5xdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xdi RCSB], [http://www.ebi.ac.uk/pdbsum/5xdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdi ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hevein and hevein-like peptides are disulfide-constrained chitin-binding cysteine-rich peptides. They are divided into three subfamilies, 6C-, 8C-, and 10C-hevein-like peptides, based on the number of cysteine residues. In addition, hevein-like peptides can exist in two forms, short and long. The long C-terminal form found in hevein and 10C-hevein-like peptides contain a C-terminal protein cargo. In contrast, the short form without a protein cargo is found in all three subfamilies. Here, we report the discovery and characterization of two novel glutamine-rich and protein cargo-free 8C-hevein-like peptides, vaccatides vH1 and vH2, from Vaccaria hispanica of the Caryophyllaceae family. Proteomic analyses showed that the vaccatides are 40-41 amino acids in length and contain a chitin-binding domain. NMR determination revealed that vaccatide vH2 displays a highly compact structure with a N-terminal cystine knot and an addition C-terminal disulfide bond. Stability studies showed that this compact structure renders vaccatide vH2 resistant to thermal, chemical and proteolytic degradation. The chitin-binding vH2 was shown to inhibit the mycelium growth of four phyto-pathogenic fungal strains with IC50 values in the micromolar range. Our findings show that vaccatides represent a new family of 8C-hevein-like peptides, which are protein cargo-free and glutamine-rich, characteristics that differentiate them from the prototypic hevein and the 10C-hevein-like peptides. In summary, this study enriches the existing library of hevein-like peptides and provides insight into their molecular diversity in sequence, structure and biosynthesis. Additionally, their highly disulfide-constrained structure could be used as a scaffold for developing metabolically and orally active peptidyl therapeutics.

-	~~Authors~~: ~~Xiao~~, T., ~~Tam~~, J.P.	+	Vaccatides: Antifungal Glutamine-Rich Hevein-Like Peptides from Vaccaria hispanica.,Wong KH, Tan WL, Kini SG, Xiao T, Serra A, Sze SK, Tam JP Front Plant Sci. 2017 Jun 21;8:1100. doi: 10.3389/fpls.2017.01100. eCollection, 2017. PMID:28680440<ref>PMID:28680440</ref>

-	~~Description: Vaccatide: Antifungal Glutamine~~-~~rich 8C~~-~~Hevein-like Peptide, vH1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5xdi" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Vaccaria hispanica]]
		+	[[Category: Tam, J P]]
	[[Category: Xiao, T]]		[[Category: Xiao, T]]
-	[[Category: ~~Tam, J.P~~]]	+	[[Category: Antifungal]]
		+	[[Category: Antifungal protein]]
		+	[[Category: Cystein]]
		+	[[Category: Hevein-like peptide]]

OCA: Protected "5xdi" [edit=sysop:move=sysop]

OCA — Wed, 05 Apr 2017 12:31:26 GMT

Protected "5xdi" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:31, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5xdi is ON HOLD Authors: Xiao, T., Tam, J.P. Description: Vaccatide: Antifungal Glutamine-rich 8C-Hevein-like Peptide, vH1 [[Category: Unreleased S...

OCA — Wed, 05 Apr 2017 12:31:25 GMT

New page: '''Unreleased structure''' The entry 5xdi is ON HOLD Authors: Xiao, T., Tam, J.P. Description: Vaccatide: Antifungal Glutamine-rich 8C-Hevein-like Peptide, vH1 [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 5xdi is ON HOLD

Authors: Xiao, T., Tam, J.P.

Description: Vaccatide: Antifungal Glutamine-rich 8C-Hevein-like Peptide, vH1
[[Category: Unreleased Structures]]
[[Category: Xiao, T]]
[[Category: Tam, J.P]]