5xea - Revision history

OCA at 08:00, 22 November 2023

OCA — Wed, 22 Nov 2023 08:00:42 GMT

←Older revision		Revision as of 08:00, 22 November 2023
Line 1:		Line 1:

	==Structure of Thogoto virus envelope glycoprotein==		==Structure of Thogoto virus envelope glycoprotein==
-	<StructureSection load='5xea' size='340' side='right' caption='[[5xea]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='5xea' size='340' side='right'caption='[[5xea]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xea]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thogv Thogv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XEA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xea]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thogoto_virus_(isolate_SiAr_126) Thogoto virus (isolate SiAr 126)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XEA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.093Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5xeb\|5xeb]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">P4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126796 THOGV])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xea OCA], [https://pdbe.org/5xea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xea RCSB], [https://www.ebi.ac.uk/pdbsum/5xea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xea ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xea OCA], [~~http~~://pdbe.org/5xea PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xea RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xea PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xea ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ENV_THOGV ENV_THOGV]] Possible role in endocytotic fusion events during infection.	+	[https://www.uniprot.org/uniprot/ENV_THOGV ENV_THOGV] Possible role in endocytotic fusion events during infection.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thogv~~]]	+	[[Category: Large Structures]]
-	[[Category: Gao~~, G F~~]]	+	[[Category: Gao GF]]
-	[[Category: Peng, R]]	+	[[Category: Peng R]]
-	[[Category: Qi, J]]	+	[[Category: Qi J]]
-	[[Category: Shi, Y]]	+	[[Category: Shi Y]]
-	~~[[Category: Fusion machine]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Thogotovirus]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 10:17, 15 November 2017

OCA — Wed, 15 Nov 2017 10:17:01 GMT

←Older revision		Revision as of 10:17, 15 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xea is ~~ON HOLD until Paper~~ Publication	+	==Structure of Thogoto virus envelope glycoprotein==
		+	<StructureSection load='5xea' size='340' side='right' caption='[[5xea]], [[Resolution\|resolution]] 2.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xea]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Thogv Thogv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XEA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xeb\|5xeb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126796 THOGV])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xea OCA], [http://pdbe.org/5xea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xea RCSB], [http://www.ebi.ac.uk/pdbsum/5xea PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xea ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ENV_THOGV ENV_THOGV]] Possible role in endocytotic fusion events during infection.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thogotoviruses are emerging tick-borne zoonotic orthomyxoviruses infecting both humans and domestic animals with severe clinical consequences. These viruses utilize a single-envelope glycoprotein (Gp) to facilitate their entry into host cells. Here, we present the Gp structures of Thogoto and Dhori viruses, both of which are members of the Thogotovirus genus in the family Orthomyxoviridae These structures, determined in the postfusion conformation, identified them as class III viral fusion proteins. It is intriguing that the Gp structures are similar to the envelope protein of baculovirus, although sharing a low sequence identity of approximately 28%. Detailed structural and phylogenic analyses demonstrated that these Gps originated from a common ancestor. Among the structures, domain I is the most conserved region, particularly the fusion loops. Domain II showed the highest variability among different viruses, which might be related to their distinct host tropism. These findings increase our understanding of the divergent evolution processes of various orthomyxoviruses and indicate potential targets for developing antiviral therapeutics by intercepting virus entry.

-	~~Authors~~:	+	Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus.,Peng R, Zhang S, Cui Y, Shi Y, Gao GF, Qi J Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8905-E8912. doi:, 10.1073/pnas.1706125114. Epub 2017 Oct 4. PMID:29073031<ref>PMID:29073031</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5xea" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Thogv]]
		+	[[Category: Gao, G F]]
		+	[[Category: Peng, R]]
		+	[[Category: Qi, J]]
		+	[[Category: Shi, Y]]
		+	[[Category: Fusion machine]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Thogotovirus]]
		+	[[Category: Viral protein]]

OCA at 12:58, 27 April 2017

OCA — Thu, 27 Apr 2017 12:58:42 GMT

←Older revision		Revision as of 12:58, 27 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xea is ON HOLD	+	The entry 5xea is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5xea" [edit=sysop:move=sysop]

OCA — Wed, 12 Apr 2017 10:41:12 GMT

Protected "5xea" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:41, 12 April 2017

OCA: New page: '''Unreleased structure''' The entry 5xea is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Apr 2017 10:41:11 GMT

New page: '''Unreleased structure''' The entry 5xea is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xea is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]