5xg3 - Revision history

OCA at 08:01, 22 November 2023

OCA — Wed, 22 Nov 2023 08:01:40 GMT

←Older revision		Revision as of 08:01, 22 November 2023
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	<StructureSection load='5xg3' size='340' side='right'caption='[[5xg3]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='5xg3' size='340' side='right'caption='[[5xg3]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xg3]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~] and [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XG3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xg3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] and [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XG3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xg2\|5xg2]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">smc, ylqA, BSU15940 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU]), scpA, SAMN05878487_2386 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xg3 OCA], [https://pdbe.org/5xg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xg3 RCSB], [https://www.ebi.ac.uk/pdbsum/5xg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xg3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xg3 OCA], [~~http~~://pdbe.org/5xg3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xg3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xg3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xg3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SMC_BACSU SMC_BACSU]] Required for chromosome condensation and partitioning.<ref>PMID:9573042</ref> <ref>PMID:9701812</ref>	+	[https://www.uniprot.org/uniprot/SMC_BACSU SMC_BACSU] Required for chromosome condensation and partitioning.<ref>PMID:9573042</ref> <ref>PMID:9701812</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5xg3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xg3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Condensin\|Condensin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
-	[[Category: ~~Bacsu~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lee, H]]	+	[[Category: Lee H]]
-	[[Category: Oh, B H]]	+	[[Category: Oh B-H]]
-	[[Category: Shin, H C]]	+	[[Category: Shin H-C]]
-	~~[[Category: Atpase]]~~	+
-	~~[[Category: Condensin]]~~	+
-	~~[[Category: Dna binding protein-cell cycle complex]]~~	+
-	~~[[Category: Scpa]]~~	+
-	~~[[Category: Smc~~]]	+

OCA at 17:03, 20 November 2019

OCA — Wed, 20 Nov 2019 17:03:42 GMT

←Older revision		Revision as of 17:03, 20 November 2019
Line 1:		Line 1:

	==Crystal structure of the ATPgS-engaged Smc head domain with an extended coiled coil bound to the C-terminal domain of ScpA derived from Bacillus subtilis==		==Crystal structure of the ATPgS-engaged Smc head domain with an extended coiled coil bound to the C-terminal domain of ScpA derived from Bacillus subtilis==
-	<StructureSection load='5xg3' size='340' side='right' caption='[[5xg3]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='5xg3' size='340' side='right'caption='[[5xg3]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xg3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XG3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xg3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835] and [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XG3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xg2\|5xg2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xg2\|5xg2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">smc, ylqA, BSU15940 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU]), scpA, SAMN05878487_2386 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xg3 OCA], [http://pdbe.org/5xg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xg3 RCSB], [http://www.ebi.ac.uk/pdbsum/5xg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xg3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xg3 OCA], [http://pdbe.org/5xg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xg3 RCSB], [http://www.ebi.ac.uk/pdbsum/5xg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xg3 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Bacsu]]
		+	[[Category: Large Structures]]
	[[Category: Lee, H]]		[[Category: Lee, H]]
	[[Category: Oh, B H]]		[[Category: Oh, B H]]

OCA at 04:17, 4 August 2017

OCA — Fri, 04 Aug 2017 04:17:28 GMT

←Older revision		Revision as of 04:17, 4 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xg3 is ~~ON HOLD~~	+	==Crystal structure of the ATPgS-engaged Smc head domain with an extended coiled coil bound to the C-terminal domain of ScpA derived from Bacillus subtilis==
		+	<StructureSection load='5xg3' size='340' side='right' caption='[[5xg3]], [[Resolution\|resolution]] 3.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xg3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XG3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xg2\|5xg2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xg3 OCA], [http://pdbe.org/5xg3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xg3 RCSB], [http://www.ebi.ac.uk/pdbsum/5xg3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xg3 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SMC_BACSU SMC_BACSU]] Required for chromosome condensation and partitioning.<ref>PMID:9573042</ref> <ref>PMID:9701812</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double helices. SMC subunits comprise an ABC ATPase "head" and a "hinge" dimerization domain connected by a 49 nm coiled-coil "arm." The heads undergo ATP-dependent engagement and disengagement to drive SMC action on the chromosome. Here, we elucidate the architecture of prokaryotic Smc dimers by high-throughput cysteine cross-linking and crystallography. Co-alignment of the Smc arms tightly closes the interarm space and misaligns the Smc head domains at the end of the rod by close apposition of their ABC signature motifs. Sandwiching of ATP molecules between Smc heads requires them to substantially tilt and translate relative to each other, thereby opening up the Smc arms. We show that this mechanochemical gating reaction regulates chromosome targeting and propose a mechanism for DNA translocation based on the merging of DNA loops upon closure of Smc arms.

-	~~Authors: Shin, H.~~-C., Lee, H., Oh, B.-H.	+	Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization.,Diebold-Durand ML, Lee H, Ruiz Avila LB, Noh H, Shin HC, Im H, Bock FP, Burmann F, Durand A, Basfeld A, Ham S, Basquin J, Oh BH, Gruber S Mol Cell. 2017 Jul 20;67(2):334-347.e5. doi: 10.1016/j.molcel.2017.06.010. Epub, 2017 Jul 6. PMID:28689660<ref>PMID:28689660</ref>

-	~~Description: Crystal structure~~ of the ~~ATPgS-engaged Smc head domain with an extended coiled coil bound to the C-terminal domain~~ of ~~ScpA derived from Bacillus subtilis~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5xg3" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lee, H]]		[[Category: Lee, H]]
-	[[Category: Shin, H.-C]]	+	[[Category: Oh, B H]]
-	[[Category: ~~Oh, B.~~-H]]	+	[[Category: Shin, H C]]
		+	[[Category: Atpase]]
		+	[[Category: Condensin]]
		+	[[Category: Dna binding protein-cell cycle complex]]
		+	[[Category: Scpa]]
		+	[[Category: Smc]]

OCA: Protected "5xg3" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2017 12:09:38 GMT

Protected "5xg3" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:09, 19 April 2017

OCA: New page: '''Unreleased structure''' The entry 5xg3 is ON HOLD Authors: Shin, H.-C., Lee, H., Oh, B.-H. Description: Crystal structure of the ATPgS-engaged Smc head domain with an extended coile...

OCA — Wed, 19 Apr 2017 12:09:37 GMT

New page: '''Unreleased structure''' The entry 5xg3 is ON HOLD Authors: Shin, H.-C., Lee, H., Oh, B.-H. Description: Crystal structure of the ATPgS-engaged Smc head domain with an extended coile...

New page

'''Unreleased structure'''

The entry 5xg3 is ON HOLD

Authors: Shin, H.-C., Lee, H., Oh, B.-H.

Description: Crystal structure of the ATPgS-engaged Smc head domain with an extended coiled coil bound to the C-terminal domain of ScpA derived from Bacillus subtilis
[[Category: Unreleased Structures]]
[[Category: Lee, H]]
[[Category: Shin, H.-C]]
[[Category: Oh, B.-H]]