5xja - Revision history

OCA at 08:04, 22 November 2023

OCA — Wed, 22 Nov 2023 08:04:03 GMT

←Older revision		Revision as of 08:04, 22 November 2023
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	<StructureSection load='5xja' size='340' side='right'caption='[[5xja]], [[Resolution\|resolution]] 3.43Å' scene=''>		<StructureSection load='5xja' size='340' side='right'caption='[[5xja]], [[Resolution\|resolution]] 3.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XJA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XJA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.43Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xjb\|5xjb]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xja OCA], [~~http~~://pdbe.org/5xja PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xja RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xja PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xja ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xja OCA], [https://pdbe.org/5xja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xja RCSB], [https://www.ebi.ac.uk/pdbsum/5xja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xja ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KIF2C_MOUSE KIF2C_MOUSE]] In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (By similarity). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/KIF2C_MOUSE KIF2C_MOUSE] In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (By similarity). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hirokawa, N~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Jiang, X~~]]	+	[[Category: Hirokawa N]]
-	[[Category: ~~Ogawa, T~~]]	+	[[Category: Jiang X]]
-	[[Category: ~~Depolymerization]]~~	+	[[Category: Ogawa T]]
-	~~[[Category: Kif2]]~~	+
-	~~[[Category: Kinesin]]~~	+
-	~~[[Category: Mcak]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Tubulin~~]]	+

OCA at 06:51, 14 October 2020

OCA — Wed, 14 Oct 2020 06:51:38 GMT

←Older revision		Revision as of 06:51, 14 October 2020
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	==The Crystal Structure of the Minimal Core Domain of the Microtubule Depolymerizer KIF2C Complexed with ADP-Mg-AlFx==		==The Crystal Structure of the Minimal Core Domain of the Microtubule Depolymerizer KIF2C Complexed with ADP-Mg-AlFx==
-	<StructureSection load='5xja' size='340' side='right' caption='[[5xja]], [[Resolution\|resolution]] 3.43Å' scene=''>	+	<StructureSection load='5xja' size='340' side='right'caption='[[5xja]], [[Resolution\|resolution]] 3.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XJA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XJA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xjb\|5xjb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xjb\|5xjb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xja OCA], [http://pdbe.org/5xja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xja RCSB], [http://www.ebi.ac.uk/pdbsum/5xja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xja ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xja OCA], [http://pdbe.org/5xja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xja RCSB], [http://www.ebi.ac.uk/pdbsum/5xja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xja ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5xja" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xja" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hirokawa, N]]		[[Category: Hirokawa, N]]
	[[Category: Jiang, X]]		[[Category: Jiang, X]]

OCA at 09:22, 27 September 2017

OCA — Wed, 27 Sep 2017 09:22:38 GMT

←Older revision		Revision as of 09:22, 27 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5xja is ~~ON HOLD~~	+	==The Crystal Structure of the Minimal Core Domain of the Microtubule Depolymerizer KIF2C Complexed with ADP-Mg-AlFx==
		+	<StructureSection load='5xja' size='340' side='right' caption='[[5xja]], [[Resolution\|resolution]] 3.43Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xjb\|5xjb]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xja OCA], [http://pdbe.org/5xja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xja RCSB], [http://www.ebi.ac.uk/pdbsum/5xja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xja ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KIF2C_MOUSE KIF2C_MOUSE]] In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (By similarity). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Microtubules (MTs) are dynamic structures that are fundamental for cell morphogenesis and motility. MT-associated motors work efficiently to perform their functions. Unlike other motile kinesins, KIF2 catalytically depolymerizes MTs from the peeled protofilament end during ATP hydrolysis. However, the detailed mechanism by which KIF2 drives processive MT depolymerization remains unknown. To elucidate the catalytic mechanism, the transitional KIF2-tubulin complex during MT depolymerization was analyzed through multiple methods, including atomic force microscopy, size-exclusion chromatography, multi-angle light scattering, small-angle X-ray scattering, analytical ultracentrifugation, and mass spectrometry. The analyses outlined the conformation in which one KIF2core domain binds tightly to two tubulin dimers in the middle pre-hydrolysis state during ATP hydrolysis, a process critical for catalytic MT depolymerization. The X-ray crystallographic structure of the KIF2core domain displays the activated conformation that sustains the large KIF2-tubulin 1:2 complex.

-	~~Authors~~:	+	Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation.,Ogawa T, Saijo S, Shimizu N, Jiang X, Hirokawa N Cell Rep. 2017 Sep 12;20(11):2626-2638. doi: 10.1016/j.celrep.2017.08.067. PMID:28903043<ref>PMID:28903043</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5xja" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hirokawa, N]]
		+	[[Category: Jiang, X]]
		+	[[Category: Ogawa, T]]
		+	[[Category: Depolymerization]]
		+	[[Category: Kif2]]
		+	[[Category: Kinesin]]
		+	[[Category: Mcak]]
		+	[[Category: Microtubule]]
		+	[[Category: Structural protein]]
		+	[[Category: Tubulin]]

OCA: Protected "5xja" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2017 12:01:15 GMT

Protected "5xja" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:01, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5xja is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 May 2017 12:01:14 GMT

New page: '''Unreleased structure''' The entry 5xja is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xja is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]