5xjy - Revision history

OCA at 22:33, 10 April 2020

OCA — Fri, 10 Apr 2020 22:33:53 GMT

←Older revision		Revision as of 22:33, 10 April 2020
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	<SX load='5xjy' size='340' side='right' viewer='molstar' caption='[[5xjy]], [[Resolution\|resolution]] 4.10Å' scene=''>		<SX load='5xjy' size='340' side='right' viewer='molstar' caption='[[5xjy]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XJY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABCA1, ABC1, CERP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABCA1, ABC1, CERP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjy OCA], [http://pdbe.org/5xjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xjy RCSB], [http://www.ebi.ac.uk/pdbsum/5xjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjy OCA], [http://pdbe.org/5xjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xjy RCSB], [http://www.ebi.ac.uk/pdbsum/5xjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 20:10, 6 March 2020

OCA — Fri, 06 Mar 2020 20:10:08 GMT

←Older revision		Revision as of 20:10, 6 March 2020
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	==Cryo-EM structure of human ABCA1==		==Cryo-EM structure of human ABCA1==
-	<~~StructureSection~~ load='5xjy' size='340' side='right'caption='[[5xjy]], [[Resolution\|resolution]] 4.10Å' scene=''>	+	<SX load='5xjy' size='340' side='right' viewer='molstar' caption='[[5xjy]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJY FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 05:57, 10 October 2019

OCA — Thu, 10 Oct 2019 05:57:46 GMT

←Older revision		Revision as of 05:57, 10 October 2019
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	==Cryo-EM structure of human ABCA1==		==Cryo-EM structure of human ABCA1==
-	<StructureSection load='5xjy' size='340' side='right' caption='[[5xjy]], [[Resolution\|resolution]] 4.10Å' scene=''>	+	<StructureSection load='5xjy' size='340' side='right'caption='[[5xjy]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJY FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gong, X]]		[[Category: Gong, X]]
	[[Category: Qian, H W]]		[[Category: Qian, H W]]

OCA at 08:24, 16 November 2017

OCA — Thu, 16 Nov 2017 08:24:31 GMT

←Older revision		Revision as of 08:24, 16 November 2017
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-	'''Unreleased structure'''

-	The entry ~~5xjy~~ is ~~ON HOLD~~	+	==Cryo-EM structure of human ABCA1==
		+	<StructureSection load='5xjy' size='340' side='right' caption='[[5xjy]], [[Resolution\|resolution]] 4.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABCA1, ABC1, CERP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjy OCA], [http://pdbe.org/5xjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xjy RCSB], [http://www.ebi.ac.uk/pdbsum/5xjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjy ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ABCA1_HUMAN ABCA1_HUMAN]] Tangier disease;Apolipoprotein A-I deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABCA1_HUMAN ABCA1_HUMAN]] cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of phospholipids and cholesterol to the extracellular acceptor apolipoprotein A-I (apoA-I) for generation of nascent high-density lipoprotein (HDL). Mutations of human ABCA1 are associated with Tangier disease and familial HDL deficiency. Here, we report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains (NBDs) display a nucleotide-free state, while the two transmembrane domains (TMDs) contact each other through a narrow interface in the intracellular leaflet of the membrane. In addition to TMDs and NBDs, two extracellular domains of ABCA1 enclose an elongated hydrophobic tunnel. Structural mapping of dozens of disease-related mutations allows potential interpretation of their diverse pathogenic mechanisms. Structural-based analysis suggests a plausible "lateral access" mechanism for ABCA1-mediated lipid export that may be distinct from the conventional alternating-access paradigm.

-	~~Authors~~:	+	Structure of the Human Lipid Exporter ABCA1.,Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X Cell. 2017 Jun 15;169(7):1228-1239.e10. doi: 10.1016/j.cell.2017.05.020. Epub, 2017 Jun 8. PMID:28602350<ref>PMID:28602350</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5xjy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Gong, X]]
		+	[[Category: Qian, H W]]
		+	[[Category: Yan, N]]
		+	[[Category: Membrane transporter]]
		+	[[Category: Transport protein]]

OCA: Protected "5xjy" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2017 12:02:44 GMT

Protected "5xjy" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:02, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5xjy is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 May 2017 12:02:43 GMT

New page: '''Unreleased structure''' The entry 5xjy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xjy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]