5xku - Revision history

OCA at 08:05, 22 November 2023

OCA — Wed, 22 Nov 2023 08:05:31 GMT

←Older revision		Revision as of 08:05, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5xku' size='340' side='right'caption='[[5xku]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='5xku' size='340' side='right'caption='[[5xku]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xku]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9infa 9infa~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xku]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xku OCA], [~~http~~://pdbe.org/5xku PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xku RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xku PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xku ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xku OCA], [https://pdbe.org/5xku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xku RCSB], [https://www.ebi.ac.uk/pdbsum/5xku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xku ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/R4NN21_9INFA R4NN21_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, C]]	+	[[Category: Chen C]]
-	[[Category: Cui, S]]	+	[[Category: Cui S]]
-	[[Category: Gao, X]]	+	[[Category: Gao X]]
-	[[Category: Jin, Q]]	+	[[Category: Jin Q]]
-	[[Category: Wang, J]]	+	[[Category: Wang J]]
-	[[Category: Wang, W]]	+	[[Category: Wang W]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Influenza some~~]]	+

OCA at 06:53, 14 October 2020

OCA — Wed, 14 Oct 2020 06:53:45 GMT

←Older revision		Revision as of 06:53, 14 October 2020
Line 1:		Line 1:

	==Crystal structure of hemagglutinin globular head from an H7N9 influenza virus in complex with a neutralizing antibody HNIgGA6==		==Crystal structure of hemagglutinin globular head from an H7N9 influenza virus in complex with a neutralizing antibody HNIgGA6==
-	<StructureSection load='5xku' size='340' side='right' caption='[[5xku]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='5xku' size='340' side='right'caption='[[5xku]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xku]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xku]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XKU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xku OCA], [http://pdbe.org/5xku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xku RCSB], [http://www.ebi.ac.uk/pdbsum/5xku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xku ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xku OCA], [http://pdbe.org/5xku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xku RCSB], [http://www.ebi.ac.uk/pdbsum/5xku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xku ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 5xku" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xku" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, C]]		[[Category: Chen, C]]
	[[Category: Cui, S]]		[[Category: Cui, S]]

OCA at 06:45, 20 December 2017

OCA — Wed, 20 Dec 2017 06:45:03 GMT

←Older revision		Revision as of 06:45, 20 December 2017
Line 3:		Line 3:
	<StructureSection load='5xku' size='340' side='right' caption='[[5xku]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='5xku' size='340' side='right' caption='[[5xku]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xku]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XKU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xku]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XKU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xku OCA], [http://pdbe.org/5xku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xku RCSB], [http://www.ebi.ac.uk/pdbsum/5xku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xku ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xku OCA], [http://pdbe.org/5xku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xku RCSB], [http://www.ebi.ac.uk/pdbsum/5xku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xku ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Since its first emergence in East China in early 2013, many cases of avian influenza A H7N9 have been reported. The disease has extended to 22 provinces in mainland China and some surrounding areas. Strategies to combat viral infection are urgently needed. We previously isolated a human monoclonal antibody, HNIgGA6, that neutralized H7N9 virus both in vitro and in vivo. In this study, we determined the crystal structure of viral hemagglutinin (HA) globular head bound to the Fab fragment of HNIgGA6. The crystal structure shows that the tip of the HNIgGA6 heavy-chain complementarity determining region 3 (HCDR3) directly interposes into the receptor binding site (RBS) and mimics, in many respects, the interaction of the sialic acid receptor. Three residues atY98, H183 and E190, that are critical to human cellular receptor binding, are also essential for HNIgGA6 recognition. At meanwhile, dual mutations at V186G and L226Q in RBS were able to disrupt viral HA1 binding with the antibody. Our study provides a better understanding of the mechanism for protective antibody recognition and sound foundation for the design of therapeutic drugs and vaccines against H7N9 influenza.ImportanceNeutralization by antibody is one of the most important mechanisms for a host to defend against viral infections. Human-originated antibody HNIgGA6 was generated in response to the natural infectious H7N9 virus and had potential use for suppression of H7N9 infection, with possible therapeutic implications. The crystal structure of HNIgGA6/HA1 complex provided new insight into the protective immune response to H7N9 virus in humans, as well as opinion for the development of effective H7N9 pandemic vaccines and antiviral molecules.
		+
		+	Structural insight into a human neutralizing antibody against influenza virus H7N9.,Chen C, Liu L, Xiao Y, Cui S, Wang J, Jin Q J Virol. 2017 Dec 6. pii: JVI.01850-17. doi: 10.1128/JVI.01850-17. PMID:29212936<ref>PMID:29212936</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5xku" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chen, C]]		[[Category: Chen, C]]
	[[Category: Cui, S]]		[[Category: Cui, S]]

OCA at 06:13, 29 November 2017

OCA — Wed, 29 Nov 2017 06:13:07 GMT

←Older revision		Revision as of 06:13, 29 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xku is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of hemagglutinin globular head from an H7N9 influenza virus in complex with a neutralizing antibody HNIgGA6==
-		+	<StructureSection load='5xku' size='340' side='right' caption='[[5xku]], [[Resolution\|resolution]] 1.78Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5xku]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XKU FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xku OCA], [http://pdbe.org/5xku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xku RCSB], [http://www.ebi.ac.uk/pdbsum/5xku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xku ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, C]]
		+	[[Category: Cui, S]]
		+	[[Category: Gao, X]]
		+	[[Category: Jin, Q]]
		+	[[Category: Wang, J]]
		+	[[Category: Wang, W]]
		+	[[Category: Antibody]]
		+	[[Category: Complex]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Immune system]]
		+	[[Category: Influenza some]]

OCA at 15:32, 27 September 2017

OCA — Wed, 27 Sep 2017 15:32:41 GMT

←Older revision		Revision as of 15:32, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xku is ON HOLD	+	The entry 5xku is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5xku" [edit=sysop:move=sysop]

OCA — Wed, 17 May 2017 14:54:34 GMT

Protected "5xku" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:54, 17 May 2017

OCA: New page: '''Unreleased structure''' The entry 5xku is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 May 2017 14:54:33 GMT

New page: '''Unreleased structure''' The entry 5xku is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xku is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]