5xnv - Revision history

OCA at 08:07, 22 November 2023

OCA — Wed, 22 Nov 2023 08:07:11 GMT

←Older revision		Revision as of 08:07, 22 November 2023
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	<StructureSection load='5xnv' size='340' side='right'caption='[[5xnv]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='5xnv' size='340' side='right'caption='[[5xnv]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xnv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XNV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xnv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XNV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.696Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnv OCA], [~~http~~://pdbe.org/5xnv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xnv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xnv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnv OCA], [https://pdbe.org/5xnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xnv RCSB], [https://www.ebi.ac.uk/pdbsum/5xnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/YETS2_HUMAN YETS2_HUMAN]] Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.<ref>PMID:19103755</ref>	+	[https://www.uniprot.org/uniprot/YETS2_HUMAN YETS2_HUMAN] Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.<ref>PMID:19103755</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guan~~, H P~~]]	+	[[Category: Guan HP]]
-	[[Category: Li~~, H T~~]]	+	[[Category: Li HT]]
-	[[Category: Zhao, D]]	+	[[Category: Zhao D]]
-	~~[[Category: Epigenetic]]~~	+
-	~~[[Category: Histone acetylation]]~~	+
-	~~[[Category: Histone reader]]~~	+
-	~~[[Category: Protein binding-peptide complex]]~~	+
-	~~[[Category: Protein complex~~]]	+

OCA at 06:55, 14 October 2020

OCA — Wed, 14 Oct 2020 06:55:36 GMT

←Older revision		Revision as of 06:55, 14 October 2020
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	==Crystal structure of YEATS2 YEATS bound to H3K27ac peptide==		==Crystal structure of YEATS2 YEATS bound to H3K27ac peptide==
-	<StructureSection load='5xnv' size='340' side='right' caption='[[5xnv]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='5xnv' size='340' side='right'caption='[[5xnv]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xnv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XNV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xnv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XNV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnv OCA], [http://pdbe.org/5xnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xnv RCSB], [http://www.ebi.ac.uk/pdbsum/5xnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnv OCA], [http://pdbe.org/5xnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xnv RCSB], [http://www.ebi.ac.uk/pdbsum/5xnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Guan, H P]]		[[Category: Guan, H P]]
	[[Category: Li, H T]]		[[Category: Li, H T]]

OCA at 06:06, 1 November 2017

OCA — Wed, 01 Nov 2017 06:06:32 GMT

←Older revision		Revision as of 06:06, 1 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xnv is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of YEATS2 YEATS bound to H3K27ac peptide==
		+	<StructureSection load='5xnv' size='340' side='right' caption='[[5xnv]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xnv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XNV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnv OCA], [http://pdbe.org/5xnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xnv RCSB], [http://www.ebi.ac.uk/pdbsum/5xnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YETS2_HUMAN YETS2_HUMAN]] Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.<ref>PMID:19103755</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recognition of modified histones by "reader" proteins constitutes a key mechanism regulating diverse chromatin-associated processes important for normal and neoplastic development. We recently identified the YEATS domain as a novel acetyllysine-binding module; however, the functional importance of YEATS domain-containing proteins in human cancer remains largely unknown. Here, we show that the YEATS2 gene is highly amplified in human non-small cell lung cancer (NSCLC) and is required for cancer cell growth and survival. YEATS2 binds to acetylated histone H3 via its YEATS domain. The YEATS2-containing ATAC complex co-localizes with H3K27 acetylation (H3K27ac) on the promoters of actively transcribed genes. Depletion of YEATS2 or disruption of the interaction between its YEATS domain and acetylated histones reduces the ATAC complex-dependent promoter H3K9ac levels and deactivates the expression of essential genes. Taken together, our study identifies YEATS2 as a histone H3K27ac reader that regulates a transcriptional program essential for NSCLC tumorigenesis.

-	~~Authors~~:	+	YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.,Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi X Nat Commun. 2017 Oct 20;8(1):1088. doi: 10.1038/s41467-017-01173-4. PMID:29057918<ref>PMID:29057918</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5xnv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Guan, H P]]
		+	[[Category: Li, H T]]
		+	[[Category: Zhao, D]]
		+	[[Category: Epigenetic]]
		+	[[Category: Histone acetylation]]
		+	[[Category: Histone reader]]
		+	[[Category: Protein binding-peptide complex]]
		+	[[Category: Protein complex]]

OCA: Protected "5xnv" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 15:36:47 GMT

Protected "5xnv" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:36, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5xnv is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 15:36:45 GMT

New page: '''Unreleased structure''' The entry 5xnv is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xnv is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]