5xp9 - Revision history

OCA at 08:08, 22 November 2023

OCA — Wed, 22 Nov 2023 08:08:47 GMT

←Older revision		Revision as of 08:08, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5xp9' size='340' side='right'caption='[[5xp9]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='5xp9' size='340' side='right'caption='[[5xp9]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xp9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XP9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XP9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BS3:BISMUTH(III)+ION'>BS3</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http:~~/~~/en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase]~~, ~~with EC number [http~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BS3:BISMUTH(III)+ION'>BS3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xp9 OCA], [~~http~~://pdbe.org/5xp9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xp9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xp9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xp9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xp9 OCA], [https://pdbe.org/5xp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xp9 RCSB], [https://www.ebi.ac.uk/pdbsum/5xp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xp9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.	+	[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Klebsiella pneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lai~~, T P~~]]	+	[[Category: Lai TP]]
-	[[Category: Ma, G]]	+	[[Category: Ma G]]
-	[[Category: Sun, H]]	+	[[Category: Sun H]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Antibiotics resistance]]~~	+
-	~~[[Category: Bismuth]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metallodrug~~]]	+

OCA at 06:56, 14 October 2020

OCA — Wed, 14 Oct 2020 06:56:23 GMT

←Older revision		Revision as of 06:56, 14 October 2020
Line 1:		Line 1:

	==Crystal structure of Bismuth bound NDM-1==		==Crystal structure of Bismuth bound NDM-1==
-	<StructureSection load='5xp9' size='340' side='right' caption='[[5xp9]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='5xp9' size='340' side='right'caption='[[5xp9]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xp9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XP9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xp9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XP9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XP9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BS3:BISMUTH(III)+ION'>BS3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BS3:BISMUTH(III)+ION'>BS3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xp9 OCA], [http://pdbe.org/5xp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xp9 RCSB], [http://www.ebi.ac.uk/pdbsum/5xp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xp9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xp9 OCA], [http://pdbe.org/5xp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xp9 RCSB], [http://www.ebi.ac.uk/pdbsum/5xp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xp9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5xp9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xp9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Lai, T P]]		[[Category: Lai, T P]]
	[[Category: Ma, G]]		[[Category: Ma, G]]

OCA at 05:04, 8 March 2018

OCA — Thu, 08 Mar 2018 05:04:56 GMT

←Older revision		Revision as of 05:04, 8 March 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xp9 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Bismuth bound NDM-1==
		+	<StructureSection load='5xp9' size='340' side='right' caption='[[5xp9]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xp9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XP9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BS3:BISMUTH(III)+ION'>BS3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xp9 OCA], [http://pdbe.org/5xp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xp9 RCSB], [http://www.ebi.ac.uk/pdbsum/5xp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xp9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Drug-resistant superbugs pose a huge threat to human health. Infections by Enterobacteriaceae producing metallo-beta-lactamases (MBLs), e.g., New Delhi metallo-beta-lactamase 1 (NDM-1) are very difficult to treat. Development of effective MBL inhibitors to revive the efficacy of existing antibiotics is highly desirable. However, such inhibitors are not clinically available till now. Here we show that an anti-Helicobacter pylori drug, colloidal bismuth subcitrate (CBS), and related Bi(III) compounds irreversibly inhibit different types of MBLs via the mechanism, with one Bi(III) displacing two Zn(II) ions as revealed by X-ray crystallography, leading to the release of Zn(II) cofactors. CBS restores meropenem (MER) efficacy against MBL-positive bacteria in vitro, and in mice infection model, importantly, also slows down the development of higher-level resistance in NDM-1-positive bacteria. This study demonstrates a high potential of Bi(III) compounds as the first broad-spectrum B1 MBL inhibitors to treat MBL-positive bacterial infection in conjunction with existing carbapenems.

-	~~Authors: Zhang~~, H., Ma, G., ~~Lai~~, ~~T.P.~~, Sun, H.	+	Bismuth antimicrobial drugs serve as broad-spectrum metallo-beta-lactamase inhibitors.,Wang R, Lai TP, Gao P, Zhang H, Ho PL, Woo PC, Ma G, Kao RY, Li H, Sun H Nat Commun. 2018 Jan 30;9(1):439. doi: 10.1038/s41467-018-02828-6. PMID:29382822<ref>PMID:29382822</ref>

-	~~Description: Crystal structure~~ of ~~Bismuth bound NDM-1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Zhang, H~~]]	+	<div class="pdbe-citations 5xp9" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Sun~~, H]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Lai, T P]]
	[[Category: Ma, G]]		[[Category: Ma, G]]
-	[[Category: ~~Lai~~, ~~T.P~~]]	+	[[Category: Sun, H]]
		+	[[Category: Zhang, H]]
		+	[[Category: Antibiotics resistance]]
		+	[[Category: Bismuth]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metallodrug]]

OCA: Protected "5xp9" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 15:39:13 GMT

Protected "5xp9" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:39, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5xp9 is ON HOLD until Paper Publication Authors: Zhang, H., Ma, G., Lai, T.P., Sun, H. Description: Crystal structure of Bismuth bound NDM-1 [[Cate...

OCA — Wed, 27 Sep 2017 15:39:12 GMT

New page: '''Unreleased structure''' The entry 5xp9 is ON HOLD until Paper Publication Authors: Zhang, H., Ma, G., Lai, T.P., Sun, H. Description: Crystal structure of Bismuth bound NDM-1 [[Cate...

New page

'''Unreleased structure'''

The entry 5xp9 is ON HOLD until Paper Publication

Authors: Zhang, H., Ma, G., Lai, T.P., Sun, H.

Description: Crystal structure of Bismuth bound NDM-1
[[Category: Unreleased Structures]]
[[Category: Zhang, H]]
[[Category: Sun, H]]
[[Category: Ma, G]]
[[Category: Lai, T.P]]