5xry - Revision history

OCA at 08:11, 22 November 2023

OCA — Wed, 22 Nov 2023 08:11:44 GMT

←Older revision		Revision as of 08:11, 22 November 2023
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	<StructureSection load='5xry' size='340' side='right'caption='[[5xry]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='5xry' size='340' side='right'caption='[[5xry]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xry]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XRY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XRY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scheffersomyces_stipitis_CBS_6054 Scheffersomyces stipitis CBS 6054]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XRY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~OCS~~:~~CYSTEINESULFONIC~~+~~ACID~~'>~~OCS~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xry OCA], [https://pdbe.org/5xry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xry RCSB], [https://www.ebi.ac.uk/pdbsum/5xry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xry ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xry OCA], [~~http~~://pdbe.org/5xry PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xry RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xry PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xry ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TKT_PICST TKT_PICST]] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	+	[https://www.uniprot.org/uniprot/TKT_PICST TKT_PICST] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:

	==See Also==		==See Also==
-	*[[Transketolase\|Transketolase]]	+	*[[Transketolase 3D structures\|Transketolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Transketolase~~]]	+	[[Category: Scheffersomyces stipitis CBS 6054]]
-	[[Category: Hsu~~, N S~~]]	+	[[Category: Hsu NS]]
-	[[Category: Li~~, T L~~]]	+	[[Category: Li TL]]
-	[[Category: Wang~~, Y L]]~~	+	[[Category: Wang YL]]
-	~~[[Category: Transferase~~]]	+

OCA at 06:57, 14 October 2020

OCA — Wed, 14 Oct 2020 06:57:47 GMT

←Older revision		Revision as of 06:57, 14 October 2020
Line 1:		Line 1:

	==Crystal Structure of Transketolase contains cysteinesufonic acid from Pichia Stipitis==		==Crystal Structure of Transketolase contains cysteinesufonic acid from Pichia Stipitis==
-	<StructureSection load='5xry' size='340' side='right' caption='[[5xry]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='5xry' size='340' side='right'caption='[[5xry]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xry]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XRY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XRY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xry]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XRY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XRY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xry OCA], [http://pdbe.org/5xry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xry RCSB], [http://www.ebi.ac.uk/pdbsum/5xry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xry ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xry OCA], [http://pdbe.org/5xry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xry RCSB], [http://www.ebi.ac.uk/pdbsum/5xry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xry ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5xry" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xry" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transketolase\|Transketolase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Transketolase]]		[[Category: Transketolase]]
	[[Category: Hsu, N S]]		[[Category: Hsu, N S]]

OCA at 05:28, 25 April 2018

OCA — Wed, 25 Apr 2018 05:28:53 GMT

←Older revision		Revision as of 05:28, 25 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xry is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of Transketolase contains cysteinesufonic acid from Pichia Stipitis==
		+	<StructureSection load='5xry' size='340' side='right' caption='[[5xry]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xry]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XRY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transketolase Transketolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.1 2.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xry OCA], [http://pdbe.org/5xry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xry RCSB], [http://www.ebi.ac.uk/pdbsum/5xry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xry ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TKT_PICST TKT_PICST]] Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	It is theoretically plausible that thiazolium mesomerizes to congeners other than carbene in a low effective dielectric binding site; especially given the energetics and uneven electronegativity of carbene groups. However, such a phenomenon has never been reported. Nine crystal structures of transketolase obtained from Pichia stipitis (TKps) are reported with subatomic resolution, where thiazolium displays an extraordinary ring-bending effect. The bent thiazolium congeners correlate with non-Kekule diradicals because there is no gain or loss of electrons. In conjunction with biophysical and biochemical analyses, it is concluded that ring bending is a result of tautomerization of thiazolium with its non- Kekule diradicals, exclusively in the binding site of TKps. The chemophysical properties of these thiazolium mesomers may account for the great variety of reactivities carried out by thiamine-diphosphate-containing (ThDP) enzymes. The stability of ThDP in living systems can be regulated by the levels of substrates, and hydration and dehydration, as well as diradical-mediated oxidative degradation.

-	~~Authors: Li, T.L~~., Hsu~~, N.S.~~, Wang, Y.L.	+	The Mesomeric Effect of Thiazolium on non-Kekule Diradicals in Pichia stipitis Transketolase.,Hsu NS, Wang YL, Lin KH, Chang CF, Lyu SY, Hsu LJ, Liu YC, Chang CY, Wu CJ, Li TL Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1802-1807. doi: 10.1002/anie.201709799., Epub 2018 Jan 15. PMID:29243887<ref>PMID:29243887</ref>

-	~~Description: Crystal Structure~~ of ~~Transketolase contains cysteinesufonic acid from Pichia Stipitis~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Li, ~~T.L~~]]	+	<div class="pdbe-citations 5xry" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Hsu~~, ~~N.S~~]]	+	== References ==
-	[[Category: Wang, Y.L]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Transketolase]]
		+	[[Category: Hsu, N S]]
		+	[[Category: Li, T L]]
		+	[[Category: Wang, Y L]]
		+	[[Category: Transferase]]

OCA: Protected "5xry" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 15:43:30 GMT

Protected "5xry" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:43, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5xry is ON HOLD until Paper Publication Authors: Li, T.L., Hsu, N.S., Wang, Y.L. Description: Crystal Structure of Transketolase contains cysteines...

OCA — Wed, 27 Sep 2017 15:43:28 GMT

New page: '''Unreleased structure''' The entry 5xry is ON HOLD until Paper Publication Authors: Li, T.L., Hsu, N.S., Wang, Y.L. Description: Crystal Structure of Transketolase contains cysteines...

New page

'''Unreleased structure'''

The entry 5xry is ON HOLD until Paper Publication

Authors: Li, T.L., Hsu, N.S., Wang, Y.L.

Description: Crystal Structure of Transketolase contains cysteinesufonic acid from Pichia Stipitis
[[Category: Unreleased Structures]]
[[Category: Li, T.L]]
[[Category: Hsu, N.S]]
[[Category: Wang, Y.L]]