5xs7 - Revision history

OCA at 22:36, 10 April 2020

OCA — Fri, 10 Apr 2020 22:36:27 GMT

OCA at 20:11, 6 March 2020

OCA — Fri, 06 Mar 2020 20:11:05 GMT

OCA: Protected "5xs7" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 10:29:20 GMT

Protected "5xs7" [edit=sysop:move=sysop]

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Revision as of 10:29, 27 September 2017

OCA: New page: ==Structure of Coxsackievirus A6 (CVA6) virus A-particle in complex with the neutralizing antibody fragment 1D5== == Structural highlights ==
<table><tr><td colspan='2'>[[5xs7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Coxsackievirus_a6 Coxsackievirus a6] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XS7 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xs7 OCA], [http://pdbe.org/5xs7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xs7 RCSB], [http://www.ebi.ac.uk/pdbsum/5xs7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xs7 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates. Despite the presence (in A-particle) or absence (in procapsid) of capsid-RNA interactions, the two CVA6 particles have essentially identical atomic capsid structures resembling the uncoating intermediates of other enteroviruses. Our near-atomic resolution structure of CVA6 A-particle complexed with a neutralizing antibody maps an immune-dominant neutralizing epitope to the surface loops of VP1. The structure-guided cell-based inhibition studies further demonstrate that these loops could serve as excellent targets for designing anti-CVA6 vaccines.Coxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development.

Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody.,Xu L, Zheng Q, Li S, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T, Zhou ZH, Yan X, Xia N Nat Commun. 2017 Sep 11;8(1):505. doi: 10.1038/s41467-017-00477-9. PMID:28894095<ref>PMID:28894095</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xs7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Coxsackievirus a6]]
[[Category: Mus musculus]]
[[Category: Cheng, T]]
[[Category: He, M Z]]
[[Category: Li, S W]]
[[Category: Xu, L F]]
[[Category: Yu, H]]
[[Category: Zheng, Q B]]
[[Category: Icosahedral]]
[[Category: Immune-complex]]
[[Category: Virus]]