5xsy - Revision history

OCA at 22:36, 10 April 2020

OCA — Fri, 10 Apr 2020 22:36:37 GMT

←Older revision		Revision as of 22:36, 10 April 2020
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	<SX load='5xsy' size='340' side='right' viewer='molstar' caption='[[5xsy]], [[Resolution\|resolution]] 4.00Å' scene=''>		<SX load='5xsy' size='340' side='right' viewer='molstar' caption='[[5xsy]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xsy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Electrophorus_electricus Electrophorus electricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XSY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XSY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xsy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Electrophorus_electricus Electrophorus electricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XSY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XSY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xsy OCA], [http://pdbe.org/5xsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xsy RCSB], [http://www.ebi.ac.uk/pdbsum/5xsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xsy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xsy OCA], [http://pdbe.org/5xsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xsy RCSB], [http://www.ebi.ac.uk/pdbsum/5xsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xsy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:11, 6 March 2020

OCA — Fri, 06 Mar 2020 20:11:10 GMT

←Older revision		Revision as of 20:11, 6 March 2020
Line 1:		Line 1:

	==Structure of the Nav1.4-beta1 complex from electric eel==		==Structure of the Nav1.4-beta1 complex from electric eel==
-	<~~StructureSection~~ load='5xsy' size='340' side='right' caption='[[5xsy]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<SX load='5xsy' size='340' side='right' viewer='molstar' caption='[[5xsy]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xsy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Electrophorus_electricus Electrophorus electricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XSY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xsy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Electrophorus_electricus Electrophorus electricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XSY FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Electrophorus electricus]]		[[Category: Electrophorus electricus]]
		+	[[Category: Large Structures]]
	[[Category: Wu, J P]]		[[Category: Wu, J P]]
	[[Category: Yan, N]]		[[Category: Yan, N]]

OCA at 06:35, 24 October 2018

OCA — Wed, 24 Oct 2018 06:35:55 GMT

←Older revision		Revision as of 06:35, 24 October 2018
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	</div>		</div>
	<div class="pdbe-citations 5xsy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xsy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>

OCA: Protected "5xsy" [edit=sysop:move=sysop]

OCA — Wed, 09 Aug 2017 09:04:32 GMT

Protected "5xsy" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:04, 9 August 2017

OCA: New page: ==Structure of the Nav1.4-beta1 complex from electric eel== == St...

OCA — Wed, 09 Aug 2017 09:04:29 GMT

New page: ==Structure of the Nav1.4-beta1 complex from electric eel== <StructureSection load='5xsy' size='340' side='right' caption='5xsy, resolution 4.00Å' scene=''> == St...

New page

==Structure of the Nav1.4-beta1 complex from electric eel==
<StructureSection load='5xsy' size='340' side='right' caption='[[5xsy]], [[Resolution|resolution]] 4.00Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xsy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Electrophorus_electricus Electrophorus electricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XSY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xsy OCA], [http://pdbe.org/5xsy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xsy RCSB], [http://www.ebi.ac.uk/pdbsum/5xsy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xsy ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SCNA_ELEEL SCNA_ELEEL]] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.<ref>PMID:2442385</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Voltage-gated sodium (Nav) channels initiate and propagate action potentials. Here, we present the cryo-EM structure of EeNav1.4, the Nav channel from electric eel, in complex with the beta1 subunit at 4.0 A resolution. The immunoglobulin domain of beta1 docks onto the extracellular L5I and L6IV loops of EeNav1.4 via extensive polar interactions, and the single transmembrane helix interacts with the third voltage-sensing domain (VSDIII). The VSDs exhibit "up" conformations, while the intracellular gate of the pore domain is kept open by a digitonin-like molecule. Structural comparison with closed NavPaS shows that the outward transfer of gating charges is coupled to the iris-like pore domain dilation through intricate force transmissions involving multiple channel segments. The IFM fast inactivation motif on the III-IV linker is plugged into the corner enclosed by the outer S4-S5 and inner S6 segments in repeats III and IV, suggesting a potential allosteric blocking mechanism for fast inactivation.

Structure of the Nav1.4-beta1 Complex from Electric Eel.,Yan Z, Zhou Q, Wang L, Wu J, Zhao Y, Huang G, Peng W, Shen H, Lei J, Yan N Cell. 2017 Jul 27;170(3):470-482.e11. doi: 10.1016/j.cell.2017.06.039. Epub 2017 , Jul 20. PMID:28735751<ref>PMID:28735751</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xsy" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Electrophorus electricus]]
[[Category: Wu, J P]]
[[Category: Yan, N]]
[[Category: Yan, Z]]
[[Category: Zhou, Q]]
[[Category: Membrane protein]]
[[Category: Voltage gated sodium channel]]