5xxf - Revision history

OCA at 08:17, 22 November 2023

OCA — Wed, 22 Nov 2023 08:17:06 GMT

←Older revision		Revision as of 08:17, 22 November 2023
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	<StructureSection load='5xxf' size='340' side='right'caption='[[5xxf]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='5xxf' size='340' side='right'caption='[[5xxf]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xxf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XXF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xxf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe] and [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XXF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5xxe\|5xxe]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxf OCA], [~~http~~://pdbe.org/5xxf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xxf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xxf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxf OCA], [https://pdbe.org/5xxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xxf RCSB], [https://www.ebi.ac.uk/pdbsum/5xxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/POZ1_SCHPO POZ1_SCHPO]] Telomeric DNA-binding protein that negatively regulates telomerase and telomere length.<ref>PMID:18535244</ref> [[http://www.uniprot.org/uniprot/TPZ1_SCHPO TPZ1_SCHPO]] Telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang and involved in telomere length regulation. recruits poz1 and ccq1 to telomeres, regulating telomere length negatively and positivels respectively.<ref>PMID:16303567</ref> <ref>PMID:18535244</ref>	+	[https://www.uniprot.org/uniprot/POZ1_SCHPO POZ1_SCHPO] Telomeric DNA-binding protein that negatively regulates telomerase and telomere length.<ref>PMID:18535244</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, H~~]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: ~~Lei, M~~]]	+	[[Category: Schizosaccharomyces pombe 972h-]]
-	[[Category: ~~Wu, J~~]]	+	[[Category: Chen H]]
-	[[Category: ~~Xue, J~~]]	+	[[Category: Lei M]]
-	[[Category: ~~Dna binding protein~~]]	+	[[Category: Wu J]]
-	[[Category: ~~Hub]]~~	+	[[Category: Xue J]]
-	~~[[Category: Sheterin]]~~	+
-	~~[[Category: Telomere~~]]	+

OCA at 07:01, 14 October 2020

OCA — Wed, 14 Oct 2020 07:01:07 GMT

←Older revision		Revision as of 07:01, 14 October 2020
Line 1:		Line 1:

	==Crystal structure of Poz1, Tpz1 and Rap1==		==Crystal structure of Poz1, Tpz1 and Rap1==
-	<StructureSection load='5xxf' size='340' side='right' caption='[[5xxf]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='5xxf' size='340' side='right'caption='[[5xxf]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xxf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XXF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xxf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XXF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xxe\|5xxe]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xxe\|5xxe]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxf OCA], [http://pdbe.org/5xxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxf RCSB], [http://www.ebi.ac.uk/pdbsum/5xxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxf OCA], [http://pdbe.org/5xxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxf RCSB], [http://www.ebi.ac.uk/pdbsum/5xxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, H]]		[[Category: Chen, H]]
	[[Category: Lei, M]]		[[Category: Lei, M]]

OCA at 06:21, 20 December 2017

OCA — Wed, 20 Dec 2017 06:21:44 GMT

←Older revision		Revision as of 06:21, 20 December 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5xxf is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of Poz1, Tpz1 and Rap1==
		+	<StructureSection load='5xxf' size='340' side='right' caption='[[5xxf]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xxf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xxe\|5xxe]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxf OCA], [http://pdbe.org/5xxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxf RCSB], [http://www.ebi.ac.uk/pdbsum/5xxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxf ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/POZ1_SCHPO POZ1_SCHPO]] Telomeric DNA-binding protein that negatively regulates telomerase and telomere length.<ref>PMID:18535244</ref> [[http://www.uniprot.org/uniprot/TPZ1_SCHPO TPZ1_SCHPO]] Telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang and involved in telomere length regulation. recruits poz1 and ccq1 to telomeres, regulating telomere length negatively and positivels respectively.<ref>PMID:16303567</ref> <ref>PMID:18535244</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Telomeric shelterin complex caps chromosome ends and plays a crucial role in telomere maintenance and protection. In the fission yeast Schizosaccharomyces pombe, shelterin is composed of telomeric single- and double-stranded DNA-binding protein subcomplexes Pot1-Tpz1 and Taz1-Rap1, which are bridged by their interacting protein Poz1. However, the structure of Poz1 and how Poz1 functions as an interaction hub in the shelterin complex remain unclear. Here we report the crystal structure of Poz1 in complex with Poz1-binding motifs of Tpz1 and Rap1. The crystal structure shows that Poz1 employs two different binding surfaces to interact with Tpz1 and Rap1. Unexpectedly, the structure also reveals that Poz1 adopts a dimeric conformation. Mutational analyses suggest that proper interactions between Tpz1, Poz1, and Rap1 in the shelterin core complex are required for telomere length homeostasis and heterochromatin structure maintenance at telomeres. Structural resemblance between Poz1 and the TRFH domains of other shelterin proteins in fission yeast and humans suggests a model for the evolution of shelterin proteins.

-	~~Authors: Xue~~, J., Chen, H., Wu, J., Lei, M.	+	Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.,Xue J, Chen H, Wu J, Takeuchi M, Inoue H, Liu Y, Sun H, Chen Y, Kanoh J, Lei M Cell Res. 2017 Dec;27(12):1503-1520. doi: 10.1038/cr.2017.145. Epub 2017 Nov 21. PMID:29160296<ref>PMID:29160296</ref>

-	~~Description: Crystal structure~~ of ~~Poz1, Tpz1 and Rap1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Lei, M]]~~	+	<div class="pdbe-citations 5xxf" style="background-color:#fffaf0;"></div>
-	~~[[Category: Xue, J]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Chen, H]]		[[Category: Chen, H]]
		+	[[Category: Lei, M]]
	[[Category: Wu, J]]		[[Category: Wu, J]]
		+	[[Category: Xue, J]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Hub]]
		+	[[Category: Sheterin]]
		+	[[Category: Telomere]]

OCA: Protected "5xxf" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 15:53:14 GMT

Protected "5xxf" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:53, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5xxf is ON HOLD until Paper Publication Authors: Xue, J., Chen, H., Wu, J., Lei, M. Description: Crystal structure of Poz1, Tpz1 and Rap1 [[Categor...

OCA — Wed, 27 Sep 2017 15:53:13 GMT

New page: '''Unreleased structure''' The entry 5xxf is ON HOLD until Paper Publication Authors: Xue, J., Chen, H., Wu, J., Lei, M. Description: Crystal structure of Poz1, Tpz1 and Rap1 [[Categor...

New page

'''Unreleased structure'''

The entry 5xxf is ON HOLD until Paper Publication

Authors: Xue, J., Chen, H., Wu, J., Lei, M.

Description: Crystal structure of Poz1, Tpz1 and Rap1
[[Category: Unreleased Structures]]
[[Category: Lei, M]]
[[Category: Xue, J]]
[[Category: Chen, H]]
[[Category: Wu, J]]