5xxw - Revision history

OCA at 22:38, 10 April 2020

OCA — Fri, 10 Apr 2020 22:38:49 GMT

←Older revision		Revision as of 22:38, 10 April 2020
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	<SX load='5xxw' size='340' side='right' viewer='molstar' caption='[[5xxw]], [[Resolution\|resolution]] 6.00Å' scene=''>		<SX load='5xxw' size='340' side='right' viewer='molstar' caption='[[5xxw]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xxw]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xxw]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XXW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xxt\|5xxt]], [[5xxv\|5xxv]], [[5xxx\|5xxx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xxt\|5xxt]], [[5xxv\|5xxv]], [[5xxx\|5xxx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxw OCA], [http://pdbe.org/5xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxw RCSB], [http://www.ebi.ac.uk/pdbsum/5xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxw OCA], [http://pdbe.org/5xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxw RCSB], [http://www.ebi.ac.uk/pdbsum/5xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5xxw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xxw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:12, 6 March 2020

OCA — Fri, 06 Mar 2020 20:12:03 GMT

←Older revision		Revision as of 20:12, 6 March 2020
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	==GDP-microtubule complexed with KIF5C in ATP state==		==GDP-microtubule complexed with KIF5C in ATP state==
-	<~~StructureSection~~ load='5xxw' size='340' side='right'caption='[[5xxw]], [[Resolution\|resolution]] 6.00Å' scene=''>	+	<SX load='5xxw' size='340' side='right' viewer='molstar' caption='[[5xxw]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xxw]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXW FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xxw]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXW FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 07:28, 6 November 2019

OCA — Wed, 06 Nov 2019 07:28:20 GMT

←Older revision		Revision as of 07:28, 6 November 2019
Line 1:		Line 1:

	==GDP-microtubule complexed with KIF5C in ATP state==		==GDP-microtubule complexed with KIF5C in ATP state==
-	<StructureSection load='5xxw' size='340' side='right' caption='[[5xxw]], [[Resolution\|resolution]] 6.00Å' scene=''>	+	<StructureSection load='5xxw' size='340' side='right'caption='[[5xxw]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xxw]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXW FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xxw]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXW FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Hirokawa, N]]		[[Category: Hirokawa, N]]

OCA at 06:36, 24 October 2018

OCA — Wed, 24 Oct 2018 06:36:23 GMT

←Older revision		Revision as of 06:36, 24 October 2018
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TBA1A_PIG TBA1A_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.		[[http://www.uniprot.org/uniprot/TBA1A_PIG TBA1A_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kinesin-1, the founding member of the kinesin superfamily of proteins, is known to use only a subset of microtubules for transport in living cells. This biased use of microtubules is proposed as the guidance cue for polarized transport in neurons, but the underlying mechanisms are still poorly understood. Here, we report that kinesin-1 binding changes the microtubule lattice and promotes further kinesin-1 binding. This high-affinity state requires the binding of kinesin-1 in the nucleotide-free state. Microtubules return to the initial low-affinity state by washing out the binding kinesin-1 or by the binding of non-hydrolyzable ATP analogue AMPPNP to kinesin-1. X-ray fiber diffraction, fluorescence speckle microscopy, and second-harmonic generation microscopy, as well as cryo-EM, collectively demonstrated that the binding of nucleotide-free kinesin-1 to GDP microtubules changes the conformation of the GDP microtubule to a conformation resembling the GTP microtubule.
		+
		+	Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport.,Shima T, Morikawa M, Kaneshiro J, Kambara T, Kamimura S, Yagi T, Iwamoto H, Uemura S, Shigematsu H, Shirouzu M, Ichimura T, Watanabe TM, Nitta R, Okada Y, Hirokawa N J Cell Biol. 2018 Oct 8. pii: jcb.201711178. doi: 10.1083/jcb.201711178. PMID:30297389<ref>PMID:30297389</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5xxw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:58, 10 October 2018

OCA — Wed, 10 Oct 2018 07:58:47 GMT

←Older revision		Revision as of 07:58, 10 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xxw is ~~ON HOLD until Paper Publication~~	+	==GDP-microtubule complexed with KIF5C in ATP state==
-		+	<StructureSection load='5xxw' size='340' side='right' caption='[[5xxw]], [[Resolution\|resolution]] 6.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5xxw]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xxt\|5xxt]], [[5xxv\|5xxv]], [[5xxx\|5xxx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxw OCA], [http://pdbe.org/5xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxw RCSB], [http://www.ebi.ac.uk/pdbsum/5xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBA1A_PIG TBA1A_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Sus scrofa]]
		+	[[Category: Hirokawa, N]]
		+	[[Category: Morikawa, M]]
		+	[[Category: Nitta, R]]
		+	[[Category: Shigematsu, H]]
		+	[[Category: Kif5c]]
		+	[[Category: Kinesin]]
		+	[[Category: Microtubule]]
		+	[[Category: Structural protein]]

OCA: Protected "5xxw" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 15:54:13 GMT

Protected "5xxw" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:54, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5xxw is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 15:54:12 GMT

New page: '''Unreleased structure''' The entry 5xxw is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xxw is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]