5xyu - Revision history

OCA at 10:20, 27 March 2024

OCA — Wed, 27 Mar 2024 10:20:57 GMT

←Older revision		Revision as of 10:20, 27 March 2024
Line 3:		Line 3:
	<SX load='5xyu' size='340' side='right' viewer='molstar' caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>		<SX load='5xyu' size='340' side='right' viewer='molstar' caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium~~ smegmatis ~~(strain atcc 700084 / mc(2)~~155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xyu]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XYU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.45Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyu OCA], [~~http~~://pdbe.org/5xyu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xyu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xyu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyu ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyu OCA], [https://pdbe.org/5xyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xyu RCSB], [https://www.ebi.ac.uk/pdbsum/5xyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. [[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS4_MYCS2 RS4_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS8_MYCS2 RS8_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302] [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS6_MYCS2 RS6_MYCS2]] Binds together with S18 to 16S ribosomal RNA.	+	[https://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.

	==See Also==		==See Also==
Line 15:		Line 16:
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycs2~~]]	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	[[Category: Gao, N]]	+	[[Category: Gao N]]
-	[[Category: Ge, X]]	+	[[Category: Ge X]]
-	[[Category: Li, Z]]	+	[[Category: Li Z]]
-	[[Category: Sanyal, S]]	+	[[Category: Sanyal S]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	[[Category: Zheng, L]]	+	[[Category: Zheng L]]
-	~~[[Category: Mycobacterium smegmatis ribosome]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Rprotein]]~~	+
-	~~[[Category: Rrna~~]]	+

OCA at 22:39, 10 April 2020

OCA — Fri, 10 Apr 2020 22:39:48 GMT

←Older revision		Revision as of 22:39, 10 April 2020
Line 3:		Line 3:
	<SX load='5xyu' size='340' side='right' viewer='molstar' caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>		<SX load='5xyu' size='340' side='right' viewer='molstar' caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XYU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyu OCA], [http://pdbe.org/5xyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xyu RCSB], [http://www.ebi.ac.uk/pdbsum/5xyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyu OCA], [http://pdbe.org/5xyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xyu RCSB], [http://www.ebi.ac.uk/pdbsum/5xyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:12, 6 March 2020

OCA — Fri, 06 Mar 2020 20:12:25 GMT

←Older revision		Revision as of 20:12, 6 March 2020
Line 1:		Line 1:

	==Small subunit of Mycobacterium smegmatis ribosome==		==Small subunit of Mycobacterium smegmatis ribosome==
-	<~~StructureSection~~ load='5xyu' size='340' side='right'caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>	+	<SX load='5xyu' size='340' side='right' viewer='molstar' caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XYU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XYU FirstGlance]. <br>
Line 8:		Line 8:
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/~~RS8_MYCS2 RS8_MYCS2~~]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA ~~central domain~~ where it ~~helps coordinate~~ assembly of the ~~platform~~ of the 30S subunit.~~[HAMAP-Rule:MF_01302]~~ [[http://www.uniprot.org/uniprot/~~RS182_MYCS2 RS182_MYCS2~~]] ~~Binds as a heterodimer with protein S6 to the central domain~~ of the 16S rRNA, where it helps ~~stabilize~~ the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:~~MF_00531~~] [[http://www.uniprot.org/uniprot/~~RS17_MYCS2 RS17_MYCS2~~]] ~~One of~~ the ~~primary rRNA~~ binding ~~proteins, it binds specifically~~ to the ~~5'-end of 16S ribosomal RNA~~. [[http://www.uniprot.org/uniprot/~~RS14Z_MYCS2 RS14Z_MYCS2~~]] Binds ~~16S rRNA, required for~~ the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. ~~Is located at~~ the ~~subunit interface close to the decoding center~~, ~~probably blocks exit of the E-site tRNA~~. [[http://www.uniprot.org/uniprot/~~RS4_MYCS2 RS4_MYCS2~~]] ~~One~~ of the ~~primary~~ rRNA ~~binding proteins~~, ~~it binds directly to 16S rRNA~~ where it ~~nucleates assembly of~~ the ~~body~~ of the 30S subunit~~. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes~~. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS6_MYCS2 RS6_MYCS2]] Binds together with S18 to 16S ribosomal RNA.	+	[[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. [[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS4_MYCS2 RS4_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS8_MYCS2 RS8_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302] [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS6_MYCS2 RS6_MYCS2]] Binds together with S18 to 16S ribosomal RNA.
		+
		+	==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]

OCA at 09:16, 18 December 2019

OCA — Wed, 18 Dec 2019 09:16:09 GMT

←Older revision		Revision as of 09:16, 18 December 2019
Line 1:		Line 1:

	==Small subunit of Mycobacterium smegmatis ribosome==		==Small subunit of Mycobacterium smegmatis ribosome==
-	<StructureSection load='5xyu' size='340' side='right' caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>	+	<StructureSection load='5xyu' size='340' side='right'caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XYU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XYU FirstGlance]. <br>
Line 11:		Line 11:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]
	[[Category: Gao, N]]		[[Category: Gao, N]]

OCA at 14:14, 11 April 2018

OCA — Wed, 11 Apr 2018 14:14:19 GMT

←Older revision		Revision as of 14:14, 11 April 2018
Line 3:		Line 3:
	<StructureSection load='5xyu' size='340' side='right' caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>		<StructureSection load='5xyu' size='340' side='right' caption='[[5xyu]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XYU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyu OCA], [http://pdbe.org/5xyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xyu RCSB], [http://www.ebi.ac.uk/pdbsum/5xyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyu OCA], [http://pdbe.org/5xyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xyu RCSB], [http://www.ebi.ac.uk/pdbsum/5xyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. [[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/~~RS4_MYCS2 RS4_MYCS2~~]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it ~~nucleates~~ assembly of the ~~body~~ of the 30S subunit. ~~With S5 and S12 plays an important role in translational accuracy.~~ [[http://www.uniprot.org/uniprot/~~RS8_MYCS2 RS8_MYCS2~~]] ~~One~~ of the ~~primary rRNA binding proteins, it binds directly to~~ 16S rRNA ~~central domain~~ where it helps ~~coordinate assembly of~~ the platform of the 30S subunit.[HAMAP-Rule:~~MF_01302~~] [[http://www.uniprot.org/uniprot/~~RS10_MYCS2 RS10_MYCS2~~]] ~~Involved in~~ the binding ~~of tRNA~~ to the ~~ribosomes~~. [[http://www.uniprot.org/uniprot/~~RS3_MYCS2 RS3_MYCS2~~]] Binds the ~~lower part~~ of the 30S subunit ~~head~~. ~~Binds mRNA in~~ the ~~70S ribosome~~, ~~positioning it for translation~~. [[http://www.uniprot.org/uniprot/~~RS182_MYCS2 RS182_MYCS2~~]] ~~Binds as a heterodimer with protein S6 to the central domain~~ of the ~~16S~~ rRNA, where it ~~helps stabilize~~ the ~~platform~~ of the 30S subunit. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307~~] [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531~~] [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS6_MYCS2 RS6_MYCS2]] Binds together with S18 to 16S ribosomal RNA.	+	[[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS8_MYCS2 RS8_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302] [[http://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. [[http://www.uniprot.org/uniprot/RS4_MYCS2 RS4_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS6_MYCS2 RS6_MYCS2]] Binds together with S18 to 16S ribosomal RNA.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Mycs2]]
	[[Category: Gao, N]]		[[Category: Gao, N]]
	[[Category: Ge, X]]		[[Category: Ge, X]]

OCA at 11:50, 6 November 2017

OCA — Mon, 06 Nov 2017 11:50:34 GMT

←Older revision		Revision as of 11:50, 6 November 2017
Line 8:		Line 8:
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/~~RS8_MYCS2 RS8_MYCS2~~]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA ~~central domain~~ where it ~~helps coordinate~~ assembly of the ~~platform~~ of the 30S subunit.~~[HAMAP-Rule:MF_01302]~~ [[http://www.uniprot.org/uniprot/~~RS182_MYCS2 RS182_MYCS2~~]] ~~Binds as a heterodimer with protein S6 to the central domain~~ of the 16S rRNA, where it helps ~~stabilize~~ the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:~~MF_00531~~] [[http://www.uniprot.org/uniprot/~~RS17_MYCS2 RS17_MYCS2~~]] ~~One of~~ the ~~primary rRNA~~ binding ~~proteins, it binds specifically~~ to the ~~5'-end of 16S ribosomal RNA~~. [[http://www.uniprot.org/uniprot/~~RS14Z_MYCS2 RS14Z_MYCS2~~]] Binds ~~16S rRNA, required for~~ the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. ~~Is located at~~ the ~~subunit interface close to the decoding center~~, ~~probably blocks exit of the E-site tRNA~~. [[http://www.uniprot.org/uniprot/~~RS4_MYCS2 RS4_MYCS2~~]] ~~One~~ of the ~~primary~~ rRNA ~~binding proteins~~, ~~it binds directly to 16S rRNA~~ where it ~~nucleates assembly of~~ the ~~body~~ of the 30S subunit~~. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes~~. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS6_MYCS2 RS6_MYCS2]] Binds together with S18 to 16S ribosomal RNA.	+	[[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. [[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS4_MYCS2 RS4_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS8_MYCS2 RS8_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302] [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS6_MYCS2 RS6_MYCS2]] Binds together with S18 to 16S ribosomal RNA.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA: Protected "5xyu" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 10:06:38 GMT

Protected "5xyu" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:06, 27 September 2017

OCA: New page: ==Small subunit of Mycobacterium smegmatis ribosome== == Structur...

OCA — Wed, 27 Sep 2017 10:06:36 GMT

New page: ==Small subunit of Mycobacterium smegmatis ribosome== <StructureSection load='5xyu' size='340' side='right' caption='5xyu, resolution 3.45Å' scene=''> == Structur...

New page

==Small subunit of Mycobacterium smegmatis ribosome==
<StructureSection load='5xyu' size='340' side='right' caption='[[5xyu]], [[Resolution|resolution]] 3.45Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xyu]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XYU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xyu OCA], [http://pdbe.org/5xyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xyu RCSB], [http://www.ebi.ac.uk/pdbsum/5xyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xyu ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS8_MYCS2 RS8_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302] [[http://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. [[http://www.uniprot.org/uniprot/RS4_MYCS2 RS4_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS6_MYCS2 RS6_MYCS2]] Binds together with S18 to 16S ribosomal RNA.
__TOC__
</StructureSection>
[[Category: Gao, N]]
[[Category: Ge, X]]
[[Category: Li, Z]]
[[Category: Sanyal, S]]
[[Category: Zhang, Y]]
[[Category: Zheng, L]]
[[Category: Mycobacterium smegmatis ribosome]]
[[Category: Ribosome]]
[[Category: Rprotein]]
[[Category: Rrna]]