5y50 - Revision history

OCA at 08:21, 22 November 2023

OCA — Wed, 22 Nov 2023 08:21:58 GMT

←Older revision		Revision as of 08:21, 22 November 2023
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	==Crystal structure of eukaryotic MATE transporter AtDTX14==		==Crystal structure of eukaryotic MATE transporter AtDTX14==
-	<StructureSection load='5y50' size='340' side='right' caption='[[5y50]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5y50' size='340' side='right'caption='[[5y50]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y50]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y50 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Y50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y50 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~DTX14~~, ~~At1g71140, F23N20.13 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=3702 ARATH])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5y50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y50 OCA], [~~http~~://pdbe.org/5y50 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5y50 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5y50 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5y50 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y50 OCA], [https://pdbe.org/5y50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y50 RCSB], [https://www.ebi.ac.uk/pdbsum/5y50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y50 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DTX14_ARATH DTX14_ARATH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
-	[[Category: Ishitani, R]]	+	[[Category: Large Structures]]
-	[[Category: Kusakizako, T]]	+	[[Category: Ishitani R]]
-	[[Category: Miyauchi, H]]	+	[[Category: Kusakizako T]]
-	[[Category: Nishizawa, T]]	+	[[Category: Miyauchi H]]
-	[[Category: Nureki, O]]	+	[[Category: Nishizawa T]]
-	~~[[Category: Alpha helical]]~~	+	[[Category: Nureki O]]
-	~~[[Category: Membrane protein~~]]	+

OCA at 06:45, 20 December 2017

OCA — Wed, 20 Dec 2017 06:45:01 GMT

←Older revision		Revision as of 06:45, 20 December 2017
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-	==Crystal structure of ~~a protein~~==	+	==Crystal structure of eukaryotic MATE transporter AtDTX14==
	<StructureSection load='5y50' size='340' side='right' caption='[[5y50]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5y50' size='340' side='right' caption='[[5y50]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y50]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y50]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y50 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y50 OCA], [http://pdbe.org/5y50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y50 RCSB], [http://www.ebi.ac.uk/pdbsum/5y50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y50 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTX14, At1g71140, F23N20.13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y50 OCA], [http://pdbe.org/5y50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y50 RCSB], [http://www.ebi.ac.uk/pdbsum/5y50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y50 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
	[[Category: Ishitani, R]]		[[Category: Ishitani, R]]
	[[Category: Kusakizako, T]]		[[Category: Kusakizako, T]]

OCA at 07:21, 6 December 2017

OCA — Wed, 06 Dec 2017 07:21:15 GMT

←Older revision		Revision as of 07:21, 6 December 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5y50 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of a protein==
		+	<StructureSection load='5y50' size='340' side='right' caption='[[5y50]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5y50]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y50 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y50 OCA], [http://pdbe.org/5y50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y50 RCSB], [http://www.ebi.ac.uk/pdbsum/5y50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y50 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mulitidrug and toxic compound extrusion (MATE) family transporters export xenobiotics to maintain cellular homeostasis. The human MATE transporters mediate the excretion of xenobiotics and cationic clinical drugs, whereas some plant MATE transporters are responsible for aluminum tolerance and secondary metabolite transport. Here we report the crystal structure of the eukaryotic MATE transporter from Arabidopsis thaliana, at 2.6 A resolution. The structure reveals that its carboxy-terminal lobe (C-lobe) contains an extensive hydrogen-bonding network with well-conserved acidic residues, and their importance is demonstrated by the structure-based mutational analysis. The structural and functional analyses suggest that the transport mechanism involves the structural change of transmembrane helix 7, induced by the formation of a hydrogen-bonding network upon the protonation of the conserved acidic residue in the C-lobe. Our findings provide insights into the transport mechanism of eukaryotic MATE transporters, which is important for the improvement of the pharmacokinetics of the clinical drugs.

-	~~Authors: Miyauchi~~, H., Kusakizako, T., Nishizawa, T., ~~Ishitani~~, R., Nureki, O.	+	Structural basis for xenobiotic extrusion by eukaryotic MATE transporter.,Miyauchi H, Moriyama S, Kusakizako T, Kumazaki K, Nakane T, Yamashita K, Hirata K, Dohmae N, Nishizawa T, Ito K, Miyaji T, Moriyama Y, Ishitani R, Nureki O Nat Commun. 2017 Nov 21;8(1):1633. doi: 10.1038/s41467-017-01541-0. PMID:29158478<ref>PMID:29158478</ref>

-	~~Description: Crystal structure~~ of ~~a protein~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Nureki, O]]~~	+	<div class="pdbe-citations 5y50" style="background-color:#fffaf0;"></div>
-	~~[[Category: Miyauchi, H]]~~	+	== References ==
-	~~[[Category: Nishizawa, T]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Ishitani, R]]		[[Category: Ishitani, R]]
	[[Category: Kusakizako, T]]		[[Category: Kusakizako, T]]
		+	[[Category: Miyauchi, H]]
		+	[[Category: Nishizawa, T]]
		+	[[Category: Nureki, O]]
		+	[[Category: Alpha helical]]
		+	[[Category: Membrane protein]]

OCA: Protected "5y50" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:08:45 GMT

Protected "5y50" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:08, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5y50 is ON HOLD until Paper Publication Authors: Miyauchi, H., Kusakizako, T., Nishizawa, T., Ishitani, R., Nureki, O. Description: Crystal structu...

OCA — Wed, 27 Sep 2017 16:08:44 GMT

New page: '''Unreleased structure''' The entry 5y50 is ON HOLD until Paper Publication Authors: Miyauchi, H., Kusakizako, T., Nishizawa, T., Ishitani, R., Nureki, O. Description: Crystal structu...

New page

'''Unreleased structure'''

The entry 5y50 is ON HOLD until Paper Publication

Authors: Miyauchi, H., Kusakizako, T., Nishizawa, T., Ishitani, R., Nureki, O.

Description: Crystal structure of a protein
[[Category: Unreleased Structures]]
[[Category: Nureki, O]]
[[Category: Miyauchi, H]]
[[Category: Nishizawa, T]]
[[Category: Ishitani, R]]
[[Category: Kusakizako, T]]