5y70 - Revision history

OCA at 10:32, 14 June 2023

OCA — Wed, 14 Jun 2023 10:32:32 GMT

←Older revision		Revision as of 10:32, 14 June 2023
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	==NMR structure of KMP11 in DPC micelle==		==NMR structure of KMP11 in DPC micelle==
-	<StructureSection load='5y70' size='340' side='right'caption='[[5y70~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='5y70' size='340' side='right'caption='[[5y70]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y70]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y70 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5Y70 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y70]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y70 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5y70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y70 OCA], [~~http~~://pdbe.org/5y70 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5y70 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5y70 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5y70 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y70 OCA], [https://pdbe.org/5y70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y70 RCSB], [https://www.ebi.ac.uk/pdbsum/5y70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y70 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KM11_TRYBB KM11_TRYBB]] May be involved in the regulation of the cytoskeleton through interaction with the subpellicular microtubules. May be involved in parasite mobility and attachment to the surface of the host cell. Behaves as a strong immunogen during infection (By similarity).	+	[https://www.uniprot.org/uniprot/KM11_TRYBB KM11_TRYBB] May be involved in the regulation of the cytoskeleton through interaction with the subpellicular microtubules. May be involved in parasite mobility and attachment to the surface of the host cell. Behaves as a strong immunogen during infection (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lim, L Z~~]]	+	[[Category: Trypanosoma brucei brucei]]
-	[[Category: ~~Lu, Y~~]]	+	[[Category: Lim LZ]]
-	[[Category: ~~Song, J~~]]	+	[[Category: Lu Y]]
-	[[Category: ~~Dpc micelle]]~~	+	[[Category: Song J]]
-	~~[[Category: Kinetoplastid membrane protein-11]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Trypanosome~~]]	+

OCA at 09:12, 21 October 2020

OCA — Wed, 21 Oct 2020 09:12:35 GMT

←Older revision		Revision as of 09:12, 21 October 2020
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	==NMR structure of KMP11 in DPC micelle==		==NMR structure of KMP11 in DPC micelle==
-	<StructureSection load='5y70' size='340' side='right' caption='[[5y70]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='5y70' size='340' side='right'caption='[[5y70]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y70]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y70 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Y70 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y70]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y70 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Y70 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5y70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y70 OCA], [http://pdbe.org/5y70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y70 RCSB], [http://www.ebi.ac.uk/pdbsum/5y70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y70 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5y70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y70 OCA], [http://pdbe.org/5y70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y70 RCSB], [http://www.ebi.ac.uk/pdbsum/5y70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y70 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lim, L Z]]		[[Category: Lim, L Z]]
	[[Category: Lu, Y]]		[[Category: Lu, Y]]

OCA at 06:16, 7 February 2018

OCA — Wed, 07 Feb 2018 06:16:10 GMT

←Older revision		Revision as of 06:16, 7 February 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5y70 is ~~ON HOLD until Paper~~ Publication	+	==NMR structure of KMP11 in DPC micelle==
		+	<StructureSection load='5y70' size='340' side='right' caption='[[5y70]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5y70]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y70 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y70 OCA], [http://pdbe.org/5y70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y70 RCSB], [http://www.ebi.ac.uk/pdbsum/5y70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y70 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KM11_TRYBB KM11_TRYBB]] May be involved in the regulation of the cytoskeleton through interaction with the subpellicular microtubules. May be involved in parasite mobility and attachment to the surface of the host cell. Behaves as a strong immunogen during infection (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kinetoplastid membrane protein-11 (KMP11) is a membrane-associated surface protein of kinetoplastids, which has a strong antigenicity but no mammalian homolog, thus representing a promising vaccine candidate. Here, by CD and NMR, we revealed that in buffer, KMP11 assumes a highly helical conformation without stable tertiary packing. Remarkably, upon interacting with dodecylphosphocholine (DPC) micelle, despite minor changes in secondary structures, KMP11 undergoes rearrangements to form a defined structure. We found that its three-dimensional structure unexpectedly adopts the classic four-helix bundle fold. The surface constituted by the N-/C-termini and conserved loop was characterized to dynamically interact with the polar phase of DPC micelle. Our results provide a structural basis for understanding KMP11 functions and further offer a promising avenue for engineering better vaccines. DATABASE: The structure coordinate of KMP11 in DPC micelle has been deposited in PDB with ID of 5Y70 and the associated NMR data were deposited in BMRB with ID of 36112.

-	~~Authors: Lu, Y~~., Lim, ~~L.Z.~~, ~~Song~~, J.	+	Kinetoplastid membrane protein-11 adopts a four-helix bundle fold in DPC micelle.,Lim LZ, Ee S, Fu J, Tan Y, He CY, Song J FEBS Lett. 2017 Nov;591(22):3793-3804. doi: 10.1002/1873-3468.12891. Epub 2017, Nov 11. PMID:29082514<ref>PMID:29082514</ref>

-	~~Description: NMR structure~~ of the ~~domain 5~~ of ~~the E~~. ~~coli ribosomal protein S1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Song, J]]~~	+	<div class="pdbe-citations 5y70" style="background-color:#fffaf0;"></div>
-	[[Category: Lim, L.Z]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lim, L Z]]
	[[Category: Lu, Y]]		[[Category: Lu, Y]]
		+	[[Category: Song, J]]
		+	[[Category: Dpc micelle]]
		+	[[Category: Kinetoplastid membrane protein-11]]
		+	[[Category: Membrane protein]]
		+	[[Category: Trypanosome]]

OCA at 05:21, 11 October 2017

OCA — Wed, 11 Oct 2017 05:21:15 GMT

←Older revision		Revision as of 05:21, 11 October 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5y70 is ON HOLD	+	The entry 5y70 is ON HOLD until Paper Publication

	Authors: Lu, Y., Lim, L.Z., Song, J.		Authors: Lu, Y., Lim, L.Z., Song, J.
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	Description: NMR structure of the domain 5 of the E. coli ribosomal protein S1		Description: NMR structure of the domain 5 of the E. coli ribosomal protein S1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Lu, Y]]
	[[Category: Song, J]]		[[Category: Song, J]]
	[[Category: Lim, L.Z]]		[[Category: Lim, L.Z]]
		+	[[Category: Lu, Y]]

OCA: Protected "5y70" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:13:14 GMT

Protected "5y70" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:13, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5y70 is ON HOLD Authors: Lu, Y., Lim, L.Z., Song, J. Description: NMR structure of the domain 5 of the E. coli ribosomal protein S1 [[Category: Unr...

OCA — Wed, 27 Sep 2017 16:13:12 GMT

New page: '''Unreleased structure''' The entry 5y70 is ON HOLD Authors: Lu, Y., Lim, L.Z., Song, J. Description: NMR structure of the domain 5 of the E. coli ribosomal protein S1 [[Category: Unr...

New page

'''Unreleased structure'''

The entry 5y70 is ON HOLD

Authors: Lu, Y., Lim, L.Z., Song, J.

Description: NMR structure of the domain 5 of the E. coli ribosomal protein S1
[[Category: Unreleased Structures]]
[[Category: Lu, Y]]
[[Category: Song, J]]
[[Category: Lim, L.Z]]