5y7n - Revision history

OCA at 08:24, 22 November 2023

OCA — Wed, 22 Nov 2023 08:24:09 GMT

←Older revision		Revision as of 08:24, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5y7n' size='340' side='right'caption='[[5y7n]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5y7n' size='340' side='right'caption='[[5y7n]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y7n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5Y7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y7N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QL:(3S,6S,8S,9S,10R,13S,14R)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol'>8QL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7n OCA], [~~http~~://pdbe.org/5y7n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5y7n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5y7n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7n ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QL:(3S,6S,8S,9S,10R,13S,14R)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol'>8QL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7n OCA], [https://pdbe.org/5y7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y7n RCSB], [https://www.ebi.ac.uk/pdbsum/5y7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>	+	[https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>

	==See Also==		==See Also==
Line 16:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cuiyun, L]]	+	[[Category: Cuiyun L]]
-	[[Category: Hong, Z]]	+	[[Category: Hong Z]]
-	[[Category: Liping, Z]]	+	[[Category: Liping Z]]
-	[[Category: Wei, Z]]	+	[[Category: Wei Z]]
-	~~[[Category: Akr1b10]]~~	+
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Steroid~~]]	+

OCA at 09:12, 21 October 2020

OCA — Wed, 21 Oct 2020 09:12:48 GMT

←Older revision		Revision as of 09:12, 21 October 2020
Line 1:		Line 1:

	==Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol==		==Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol==
-	<StructureSection load='5y7n' size='340' side='right' caption='[[5y7n]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5y7n' size='340' side='right'caption='[[5y7n]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y7n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7N OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Y7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y7n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Y7N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8QL:(3S,6S,8S,9S,10R,13S,14R)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol'>8QL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QL:(3S,6S,8S,9S,10R,13S,14R)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol'>8QL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7n OCA], [http://pdbe.org/5y7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7n RCSB], [http://www.ebi.ac.uk/pdbsum/5y7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7n OCA], [http://pdbe.org/5y7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7n RCSB], [http://www.ebi.ac.uk/pdbsum/5y7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>		[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
		+
		+	==See Also==
		+	*[[Aldo-keto reductase 3D structures\|Aldo-keto reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cuiyun, L]]		[[Category: Cuiyun, L]]
	[[Category: Hong, Z]]		[[Category: Hong, Z]]

OCA at 07:18, 29 August 2018

OCA — Wed, 29 Aug 2018 07:18:02 GMT

←Older revision		Revision as of 07:18, 29 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5y7n is ON HOLD until Paper Publication~~	+	==Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol==
-		+	<StructureSection load='5y7n' size='340' side='right' caption='[[5y7n]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors: Hong, Z., Liping, Z., Cuiyun, L., Wei, Z.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5y7n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y7N FirstGlance]. <br>
-	~~Description:~~ Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8QL:(3S,6S,8S,9S,10R,13S,14R)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol'>8QL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7n OCA], [http://pdbe.org/5y7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7n RCSB], [http://www.ebi.ac.uk/pdbsum/5y7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7n ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Wei~~, Z]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Cuiyun, L]]		[[Category: Cuiyun, L]]
	[[Category: Hong, Z]]		[[Category: Hong, Z]]
	[[Category: Liping, Z]]		[[Category: Liping, Z]]
		+	[[Category: Wei, Z]]
		+	[[Category: Akr1b10]]
		+	[[Category: Antitumor protein]]
		+	[[Category: Complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Steroid]]

OCA at 08:00, 4 October 2017

OCA — Wed, 04 Oct 2017 08:00:08 GMT

←Older revision		Revision as of 08:00, 4 October 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5y7n is ON HOLD	+	The entry 5y7n is ON HOLD until Paper Publication

	Authors: Hong, Z., Liping, Z., Cuiyun, L., Wei, Z.		Authors: Hong, Z., Liping, Z., Cuiyun, L., Wei, Z.
Line 7:		Line 7:
	Description: Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol		Description: Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Hong, Z]]
-	[[Category: Liping, Z]]
	[[Category: Wei, Z]]		[[Category: Wei, Z]]
	[[Category: Cuiyun, L]]		[[Category: Cuiyun, L]]
		+	[[Category: Hong, Z]]
		+	[[Category: Liping, Z]]

OCA: Protected "5y7n" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:14:20 GMT

Protected "5y7n" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:14, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5y7n is ON HOLD Authors: Hong, Z., Liping, Z., Cuiyun, L., Wei, Z. Description: Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-en...

OCA — Wed, 27 Sep 2017 16:14:18 GMT

New page: '''Unreleased structure''' The entry 5y7n is ON HOLD Authors: Hong, Z., Liping, Z., Cuiyun, L., Wei, Z. Description: Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-en...

New page

'''Unreleased structure'''

The entry 5y7n is ON HOLD

Authors: Hong, Z., Liping, Z., Cuiyun, L., Wei, Z.

Description: Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol
[[Category: Unreleased Structures]]
[[Category: Hong, Z]]
[[Category: Liping, Z]]
[[Category: Wei, Z]]
[[Category: Cuiyun, L]]