5y9k - Revision history

OCA at 09:13, 21 October 2020

OCA — Wed, 21 Oct 2020 09:13:58 GMT

←Older revision		Revision as of 09:13, 21 October 2020
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	==Structure of the belimumab Fab fragment==		==Structure of the belimumab Fab fragment==
-	<StructureSection load='5y9k' size='340' side='right' caption='[[5y9k]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5y9k' size='340' side='right'caption='[[5y9k]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y9k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9K OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Y9K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y9k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Y9K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5y9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9k OCA], [http://pdbe.org/5y9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9k RCSB], [http://www.ebi.ac.uk/pdbsum/5y9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9k ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5y9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9k OCA], [http://pdbe.org/5y9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9k RCSB], [http://www.ebi.ac.uk/pdbsum/5y9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9k ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BAFF, a member of the TNF superfamily, has been recognized as a good target for autoimmune diseases. Belimumab, an anti-BAFF monoclonal antibody, was approved by the FDA for use in treating systemic lupus erythematosus. However, the molecular basis of BAFF neutralization by belimumab remains unclear. Here our crystal structure of the BAFF-belimumab Fab complex shows the precise epitope and the BAFF-neutralizing mechanism of belimumab, and demonstrates that the therapeutic activity of belimumab involves not only antagonizing the BAFF-receptor interaction, but also disrupting the formation of the more active BAFF 60-mer to favor the induction of the less active BAFF trimer through interaction with the flap region of BAFF. In addition, the belimumab HCDR3 loop mimics the DxL(V/L) motif of BAFF receptors, thereby binding to BAFF in a similar manner as endogenous BAFF receptors. Our data thus provides insights for the design of new drugs targeting BAFF for the treatment of autoimmune diseases.
		+
		+	BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus.,Shin W, Lee HT, Lim H, Lee SH, Son JY, Lee JU, Yoo KY, Ryu SE, Rhie J, Lee JY, Heo YS Nat Commun. 2018 Mar 23;9(1):1200. doi: 10.1038/s41467-018-03620-2. PMID:29572471<ref>PMID:29572471</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5y9k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Heo, Y S]]		[[Category: Heo, Y S]]
	[[Category: Shin, W]]		[[Category: Shin, W]]

OCA at 07:21, 22 February 2018

OCA — Thu, 22 Feb 2018 07:21:08 GMT

←Older revision		Revision as of 07:21, 22 February 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5y9k is ~~ON HOLD until Paper Publication~~	+	==Structure of the belimumab Fab fragment==
-		+	<StructureSection load='5y9k' size='340' side='right' caption='[[5y9k]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5y9k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y9K FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9k OCA], [http://pdbe.org/5y9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9k RCSB], [http://www.ebi.ac.uk/pdbsum/5y9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9k ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Heo, Y S]]
		+	[[Category: Shin, W]]
		+	[[Category: Antibody]]
		+	[[Category: Baff]]
		+	[[Category: Belimumab]]
		+	[[Category: Lupus]]
		+	[[Category: Protein binding]]

OCA: Protected "5y9k" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:18:13 GMT

Protected "5y9k" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:18, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5y9k is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 16:18:12 GMT

New page: '''Unreleased structure''' The entry 5y9k is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5y9k is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]