5y9p - Revision history

OCA at 08:25, 22 November 2023

OCA — Wed, 22 Nov 2023 08:25:08 GMT

←Older revision		Revision as of 08:25, 22 November 2023
Line 1:		Line 1:

	==Staphylococcus aureus RNase HII==		==Staphylococcus aureus RNase HII==
-	<StructureSection load='5y9p' size='340' side='right' caption='[[5y9p]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5y9p' size='340' side='right'caption='[[5y9p]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y9p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Y9P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y9P FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>rnhB, AYM28_06605, AYM37_06605, ERS072738_01674, ERS074020_01342, HMPREF3211_01288 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1280~~ "~~Micrococcus aureus~~" ~~(Rosenbach 1884) Zopf 1885])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9p OCA], [https://pdbe.org/5y9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y9p RCSB], [https://www.ebi.ac.uk/pdbsum/5y9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9p ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5y9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9p OCA], [~~http~~://pdbe.org/5y9p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5y9p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5y9p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9p ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~A0A0D6HS53_STAAU A0A0D6HS53_STAAU]~~] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.[HAMAP-Rule:MF_00052~~][RuleBase:RU003515][SAAS:SAAS00946624~~]	+	[https://www.uniprot.org/uniprot/RNH2_STAA8 RNH2_STAA8] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.[HAMAP-Rule:MF_00052]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5y9p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5y9p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ribonuclease H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Hang, T~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Wu, M~~]]	+	[[Category: Hang T]]
-	[[Category: ~~Zhang, X~~]]	+	[[Category: Wu M]]
-	[[Category: ~~Endonuclease]]~~	+	[[Category: Zhang X]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:47, 12 September 2018

OCA — Wed, 12 Sep 2018 07:47:20 GMT

←Older revision		Revision as of 07:47, 12 September 2018
Line 3:		Line 3:
	<StructureSection load='5y9p' size='340' side='right' caption='[[5y9p]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5y9p' size='340' side='right' caption='[[5y9p]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y9p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y9P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y9P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rnhB, AYM28_06605, AYM37_06605, ERS072738_01674, ERS074020_01342, HMPREF3211_01288 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9p OCA], [http://pdbe.org/5y9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9p RCSB], [http://www.ebi.ac.uk/pdbsum/5y9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9p OCA], [http://pdbe.org/5y9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9p RCSB], [http://www.ebi.ac.uk/pdbsum/5y9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9p ProSAT]</span></td></tr>

OCA at 18:38, 1 August 2018

OCA — Wed, 01 Aug 2018 18:38:45 GMT

←Older revision		Revision as of 18:38, 1 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5y9p is ~~ON HOLD until Paper~~ Publication	+	==Staphylococcus aureus RNase HII==
		+	<StructureSection load='5y9p' size='340' side='right' caption='[[5y9p]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5y9p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y9P FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9p OCA], [http://pdbe.org/5y9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9p RCSB], [http://www.ebi.ac.uk/pdbsum/5y9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9p ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A0D6HS53_STAAU A0A0D6HS53_STAAU]] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.[HAMAP-Rule:MF_00052][RuleBase:RU003515][SAAS:SAAS00946624]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RNase HII exists ubiquitously in organisms and functions as a monomer in prokaryotes. We determined the crystal structure of Staphylococcus aureus RNase HII (Sa-RNase HII), which displays a novel dimer conformation, with the active site of each monomer covered by the other one. Both small-angle X-ray scattering and gel-filtration analysis confirmed that Sa-RNase HII exists as a homodimer in solution. Enzymatic analysis revealed that the "self-inhibited" dimeric form is catalytically active. Furthermore, continuous-wave electron paramagnetic resonance experiments clarified that the Sa-RNase HII dimer undergoes a large conformational change upon substrate binding, but remains a dimer to catalyze the reaction. Our structural and biochemical studies identified a novel functional dimer of Sa-RNase HII with distinct regulation mechanism for its catalytic activity.

-	~~Authors: Hang~~, T~~.R.~~, Wu, M~~.H.~~, ~~Zhang~~, X.Z.	+	Structural insights into a novel functional dimer of Staphylococcus aureus RNase HII.,Hang T, Zhang X, Wu M, Wang C, Ling S, Xu L, Gong Q, Tian C, Zhang X, Zang J Biochem Biophys Res Commun. 2018 Jul 10. pii: S0006-291X(18)31521-3. doi:, 10.1016/j.bbrc.2018.07.026. PMID:30005877<ref>PMID:30005877</ref>

-	~~Description~~: ~~Staphylococcus aureus RNase HII~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Zhang~~, ~~X.Z~~]]	+	<div class="pdbe-citations 5y9p" style="background-color:#fffaf0;"></div>
-	[[Category: Wu, M.H]]	+	== References ==
-	[[Category: ~~Hang~~, ~~T.R~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ribonuclease H]]
		+	[[Category: Hang, T]]
		+	[[Category: Wu, M]]
		+	[[Category: Zhang, X]]
		+	[[Category: Endonuclease]]
		+	[[Category: Hydrolase]]

OCA: Protected "5y9p" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:18:28 GMT

Protected "5y9p" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:18, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5y9p is ON HOLD until Paper Publication Authors: Hang, T.R., Wu, M.H., Zhang, X.Z. Description: Staphylococcus aureus RNase HII [[Category: Unrelea...

OCA — Wed, 27 Sep 2017 16:18:27 GMT

New page: '''Unreleased structure''' The entry 5y9p is ON HOLD until Paper Publication Authors: Hang, T.R., Wu, M.H., Zhang, X.Z. Description: Staphylococcus aureus RNase HII [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 5y9p is ON HOLD until Paper Publication

Authors: Hang, T.R., Wu, M.H., Zhang, X.Z.

Description: Staphylococcus aureus RNase HII
[[Category: Unreleased Structures]]
[[Category: Zhang, X.Z]]
[[Category: Wu, M.H]]
[[Category: Hang, T.R]]