5yaz - Revision history

OCA at 08:25, 22 November 2023

OCA — Wed, 22 Nov 2023 08:25:35 GMT

←Older revision		Revision as of 08:25, 22 November 2023
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	==Crystal structure of the ANKRD domain of KANK1==		==Crystal structure of the ANKRD domain of KANK1==
-	<StructureSection load='5yaz' size='340' side='right' caption='[[5yaz]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5yaz' size='340' side='right'caption='[[5yaz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yaz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yaz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YAZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ACT:ACETATE+ION'>ACT</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5yay\|5yay]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Kank1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yaz OCA], [https://pdbe.org/5yaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yaz RCSB], [https://www.ebi.ac.uk/pdbsum/5yaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yaz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yaz OCA], [~~http~~://pdbe.org/5yaz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yaz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yaz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yaz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E9Q238_MOUSE E9Q238_MOUSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pan, W~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Wei, Z~~]]	+	[[Category: Pan W]]
-	[[Category: ~~Ank repeat]]~~	+	[[Category: Wei Z]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Scaffold protein~~]]	+

OCA at 08:58, 27 December 2017

OCA — Wed, 27 Dec 2017 08:58:32 GMT

←Older revision		Revision as of 08:58, 27 December 2017
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	<StructureSection load='5yaz' size='340' side='right' caption='[[5yaz]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5yaz' size='340' side='right' caption='[[5yaz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yaz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yaz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5yay\|5yay]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5yay\|5yay]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kank1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yaz OCA], [http://pdbe.org/5yaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yaz RCSB], [http://www.ebi.ac.uk/pdbsum/5yaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yaz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yaz OCA], [http://pdbe.org/5yaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yaz RCSB], [http://www.ebi.ac.uk/pdbsum/5yaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yaz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kidney ankyrin repeat-containing proteins (KANK1/2/3/4) belong to a family of scaffold proteins, playing critical roles in cytoskeleton organization, cell polarity and migration. Mutations in KANK proteins are implicated in cancers and genetic diseases, such as nephrotic syndrome. KANK proteins can bind various target proteins through different protein regions, including a highly conserved ankyrin repeat domain (ANKRD). However, the molecular basis for target recognition by the ANKRD remains elusive. In this study, we solved a high-resolution crystal structure of the ANKRD of KANK1 in complex with a short sequence of the motor protein kinesin family member 21A (KIF21A), revealing that the highly specific target-binding mode of the ANKRD involves combinatorial use of two interfaces. Mutations in either interface disrupted the KANK1/KIF21A interaction. Cellular immunofluorescence localization analysis indicates that binding-deficient mutations block recruitment of KIF21A to focal adhesions by KANK1. In conclusion, our structural study provides mechanistic explanations for the ANKRD-mediated recognition of KIF21A and for many disease-related mutations identified in human KANK proteins.
		+
		+	Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion.,Pan W, Sun K, Tang K, Xiao Q, Ma C, Yu C, Wei Z J Biol Chem. 2017 Dec 7. pii: M117.815779. doi: 10.1074/jbc.M117.815779. PMID:29217769<ref>PMID:29217769</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5yaz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Pan, W]]		[[Category: Pan, W]]
	[[Category: Wei, Z]]		[[Category: Wei, Z]]

OCA at 06:22, 20 December 2017

OCA — Wed, 20 Dec 2017 06:22:28 GMT

←Older revision		Revision as of 06:22, 20 December 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5yaz ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of the ANKRD domain of KANK1==
-		+	<StructureSection load='5yaz' size='340' side='right' caption='[[5yaz]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~Authors~~: ~~Wei, Z~~.~~, Pan, W~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5yaz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAZ FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the ANKRD domain of KANK1~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5yay\|5yay]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yaz OCA], [http://pdbe.org/5yaz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yaz RCSB], [http://www.ebi.ac.uk/pdbsum/5yaz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yaz ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Pan, W]]		[[Category: Pan, W]]
	[[Category: Wei, Z]]		[[Category: Wei, Z]]
		+	[[Category: Ank repeat]]
		+	[[Category: Protein binding]]
		+	[[Category: Scaffold protein]]

OCA: Protected "5yaz" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:21:19 GMT

Protected "5yaz" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:21, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5yaz is ON HOLD until Paper Publication Authors: Wei, Z., Pan, W. Description: Crystal structure of the ANKRD domain of KANK1 [[Category: Unrelease...

OCA — Wed, 27 Sep 2017 16:21:18 GMT

New page: '''Unreleased structure''' The entry 5yaz is ON HOLD until Paper Publication Authors: Wei, Z., Pan, W. Description: Crystal structure of the ANKRD domain of KANK1 [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 5yaz is ON HOLD until Paper Publication

Authors: Wei, Z., Pan, W.

Description: Crystal structure of the ANKRD domain of KANK1
[[Category: Unreleased Structures]]
[[Category: Pan, W]]
[[Category: Wei, Z]]