5ybb - Revision history

OCA at 06:47, 7 February 2018

OCA — Wed, 07 Feb 2018 06:47:12 GMT

←Older revision		Revision as of 06:47, 7 February 2018
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	<StructureSection load='5ybb' size='340' side='right' caption='[[5ybb]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='5ybb' size='340' side='right' caption='[[5ybb]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ybb]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YBB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ybb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Cals4 Cals4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HsdM, TTE1547 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273068 CALS4]), HsdM, TTE1545 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273068 CALS4])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ybb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybb OCA], [http://pdbe.org/5ybb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ybb RCSB], [http://www.ebi.ac.uk/pdbsum/5ybb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ybb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybb OCA], [http://pdbe.org/5ybb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ybb RCSB], [http://www.ebi.ac.uk/pdbsum/5ybb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybb ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cals4]]
	[[Category: Gao, P]]		[[Category: Gao, P]]
	[[Category: Liu, Y P]]		[[Category: Liu, Y P]]

OCA at 06:14, 29 November 2017

OCA — Wed, 29 Nov 2017 06:14:19 GMT

←Older revision		Revision as of 06:14, 29 November 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5ybb is ~~ON HOLD until Paper~~ Publication	+	==Structural basis underlying complex assembly andconformational transition of the type I R-M system==
		+	<StructureSection load='5ybb' size='340' side='right' caption='[[5ybb]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ybb]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YBB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ybb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybb OCA], [http://pdbe.org/5ybb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ybb RCSB], [http://www.ebi.ac.uk/pdbsum/5ybb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybb ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type I restriction-modification (R-M) systems are multisubunit enzymes with separate DNA-recognition (S), methylation (M), and restriction (R) subunits. Despite extensive studies spanning five decades, the detailed molecular mechanisms underlying subunit assembly and conformational transition are still unclear due to the lack of high-resolution structural information. Here, we report the atomic structure of a type I MTase complex (2M+1S) bound to DNA and cofactor S-adenosyl methionine in the "open" form. The intermolecular interactions between M and S subunits are mediated by a four-helix bundle motif, which also determines the specificity of the interaction. Structural comparison between open and previously reported low-resolution "closed" structures identifies the huge conformational changes within the MTase complex. Furthermore, biochemical results show that R subunits prefer to load onto the closed form MTase. Based on our results, we proposed an updated model for the complex assembly. The work reported here provides guidelines for future applications in molecular biology.

-	~~Authors~~:	+	Structural basis underlying complex assembly and conformational transition of the type I R-M system.,Liu YP, Tang Q, Zhang JZ, Tian LF, Gao P, Yan XX Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11151-11156. doi:, 10.1073/pnas.1711754114. Epub 2017 Oct 2. PMID:28973912<ref>PMID:28973912</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ybb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gao, P]]
		+	[[Category: Liu, Y P]]
		+	[[Category: Tang, Q]]
		+	[[Category: Tian, L F]]
		+	[[Category: Yan, X X]]
		+	[[Category: Zhang, J Z]]
		+	[[Category: Dna binding protein-dna complex]]
		+	[[Category: Protein complex typei rm system mtase ecoki]]

OCA at 06:24, 8 November 2017

OCA — Wed, 08 Nov 2017 06:24:14 GMT

←Older revision		Revision as of 06:24, 8 November 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ybb is ON HOLD	+	The entry 5ybb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5ybb" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:22:08 GMT

Protected "5ybb" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:22, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5ybb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 16:22:07 GMT

New page: '''Unreleased structure''' The entry 5ybb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5ybb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]