5ydl - Revision history

OCA at 09:16, 21 October 2020

OCA — Wed, 21 Oct 2020 09:16:35 GMT

←Older revision		Revision as of 09:16, 21 October 2020
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	==The crystal structure of the Acyl Transferase domain of SpnD complex with 2-(pent-4-yn-1-yl)malonyl==		==The crystal structure of the Acyl Transferase domain of SpnD complex with 2-(pent-4-yn-1-yl)malonyl==
-	<StructureSection load='5ydl' size='340' side='right' caption='[[5ydl]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5ydl' size='340' side='right'caption='[[5ydl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ydl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YDL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ydl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YDL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUV:(2R)-2-methanoylhept-6-ynoic+acid'>DUV</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUV:(2R)-2-methanoylhept-6-ynoic+acid'>DUV</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ydl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ydl OCA], [http://pdbe.org/5ydl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ydl RCSB], [http://www.ebi.ac.uk/pdbsum/5ydl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ydl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ydl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ydl OCA], [http://pdbe.org/5ydl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ydl RCSB], [http://www.ebi.ac.uk/pdbsum/5ydl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ydl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Li, Y]]		[[Category: Li, Y]]
	[[Category: Qu, X D]]		[[Category: Qu, X D]]

OCA at 07:17, 23 May 2018

OCA — Wed, 23 May 2018 07:17:20 GMT

←Older revision		Revision as of 07:17, 23 May 2018
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-	'''Unreleased structure'''

-	The ~~entry~~ 5ydl is ~~ON HOLD until Paper~~ Publication	+	==The crystal structure of the Acyl Transferase domain of SpnD complex with 2-(pent-4-yn-1-yl)malonyl==
		+	<StructureSection load='5ydl' size='340' side='right' caption='[[5ydl]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ydl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YDL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUV:(2R)-2-methanoylhept-6-ynoic+acid'>DUV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ydl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ydl OCA], [http://pdbe.org/5ydl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ydl RCSB], [http://www.ebi.ac.uk/pdbsum/5ydl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ydl ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polyketides are a large family of pharmaceutically important natural products, and the structural modification of their scaffolds is significant for drug development. Herein, we report high-resolution X-ray crystal structures of the broadly selective acyltransferase (AT) from the splenocin polyketide synthase (SpnD-AT) in the apo form and in complex with benzylmalonyl and pentynylmalonyl extender unit mimics. These structures revealed the molecular basis for the stereoselectivity and substrate specificity of SpnD-AT, and enabled the engineering of the industrially important Ery-AT6 to broaden its substrate scope to include three new types of extender units.

-	~~Authors~~:	+	Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin.,Li Y, Zhang W, Zhang H, Tian W, Wu L, Wang S, Zheng M, Zhang J, Sun C, Deng Z, Sun Y, Qu X, Zhou J Angew Chem Int Ed Engl. 2018 May 14;57(20):5823-5827. doi:, 10.1002/anie.201802805. Epub 2018 Apr 14. PMID:29536601<ref>PMID:29536601</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ydl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Li, Y]]
		+	[[Category: Qu, X D]]
		+	[[Category: Zhou, J H]]
		+	[[Category: Acyl transferase domain]]
		+	[[Category: Pk]]
		+	[[Category: Transferase]]

OCA at 05:21, 11 October 2017

OCA — Wed, 11 Oct 2017 05:21:54 GMT

←Older revision		Revision as of 05:21, 11 October 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ydl is ON HOLD	+	The entry 5ydl is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5ydl" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:26:33 GMT

Protected "5ydl" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:26, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5ydl is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 16:26:32 GMT

New page: '''Unreleased structure''' The entry 5ydl is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5ydl is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]