5yh0 - Revision history

OCA at 09:19, 21 October 2020

OCA — Wed, 21 Oct 2020 09:19:17 GMT

←Older revision		Revision as of 09:19, 21 October 2020
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	==The structure of DrFam20C1==		==The structure of DrFam20C1==
-	<StructureSection load='5yh0' size='340' side='right' caption='[[5yh0]], [[Resolution\|resolution]] 3.45Å' scene=''>	+	<StructureSection load='5yh0' size='340' side='right'caption='[[5yh0]], [[Resolution\|resolution]] 3.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yh0]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YH0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YH0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yh0]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YH0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YH0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yh0 OCA], [http://pdbe.org/5yh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yh0 RCSB], [http://www.ebi.ac.uk/pdbsum/5yh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yh0 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yh0 OCA], [http://pdbe.org/5yh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yh0 RCSB], [http://www.ebi.ac.uk/pdbsum/5yh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yh0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Xiao, J]]		[[Category: Xiao, J]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 13:48, 11 April 2018

OCA — Wed, 11 Apr 2018 13:48:02 GMT

←Older revision		Revision as of 13:48, 11 April 2018
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-	'''Unreleased structure'''

-	The ~~entry~~ 5yh0 is ~~ON HOLD until Paper~~ Publication	+	==The structure of DrFam20C1==
		+	<StructureSection load='5yh0' size='340' side='right' caption='[[5yh0]], [[Resolution\|resolution]] 3.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5yh0]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YH0 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yh0 OCA], [http://pdbe.org/5yh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yh0 RCSB], [http://www.ebi.ac.uk/pdbsum/5yh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yh0 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Fam20 proteins are novel kinases that phosphorylate secreted proteins and proteoglycans. Fam20C phosphorylates hundreds of secreted proteins and is activated by the pseudokinase Fam20A. Fam20B phosphorylates a xylose residue to regulate proteoglycan synthesis. Despite these wide-ranging and important functions, the molecular and structural basis for the regulation and substrate specificity of these kinases are unknown. Here we report molecular characterizations of all three Fam20 kinases, and show that Fam20C is activated by the formation of an evolutionarily conserved homodimer or heterodimer with Fam20A. Fam20B has a unique active site for recognizing Galbeta1-4Xylbeta1, the initiator disaccharide within the tetrasaccharide linker region of proteoglycans. We further show that in animals the monomeric Fam20B preceded the appearance of the dimeric Fam20C, and the dimerization trait of Fam20C emerged concomitantly with a change in substrate specificity. Our results provide comprehensive structural, biochemical, and evolutionary insights into the function of the Fam20 kinases.

-	~~Authors: Hui, Z~~., ~~Junyu~~, X.	+	Structure and evolution of the Fam20 kinases.,Zhang H, Zhu Q, Cui J, Wang Y, Chen MJ, Guo X, Tagliabracci VS, Dixon JE, Xiao J Nat Commun. 2018 Mar 23;9(1):1218. doi: 10.1038/s41467-018-03615-z. PMID:29572475<ref>PMID:29572475</ref>

-	~~Description: The structure~~ of ~~DrFam20C1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Hui~~, Z]]	+	<div class="pdbe-citations 5yh0" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Junyu, X~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Xiao, J]]
		+	[[Category: Zhang, H]]
		+	[[Category: Kinase]]
		+	[[Category: Transferase]]

OCA at 05:22, 11 October 2017

OCA — Wed, 11 Oct 2017 05:22:54 GMT

←Older revision		Revision as of 05:22, 11 October 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5yh0 is ON HOLD	+	The entry 5yh0 is ON HOLD until Paper Publication

	Authors: Hui, Z., Junyu, X.		Authors: Hui, Z., Junyu, X.

OCA: Protected "5yh0" [edit=sysop:move=sysop]

OCA — Wed, 04 Oct 2017 08:05:53 GMT

Protected "5yh0" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:05, 4 October 2017

OCA: New page: '''Unreleased structure''' The entry 5yh0 is ON HOLD Authors: Hui, Z., Junyu, X. Description: The structure of DrFam20C1 Category: Unreleased Structures Category: Hui, Z [[Cate...

OCA — Wed, 04 Oct 2017 08:05:52 GMT

New page: '''Unreleased structure''' The entry 5yh0 is ON HOLD Authors: Hui, Z., Junyu, X. Description: The structure of DrFam20C1 Category: Unreleased Structures Category: Hui, Z [[Cate...

New page

'''Unreleased structure'''

The entry 5yh0 is ON HOLD

Authors: Hui, Z., Junyu, X.

Description: The structure of DrFam20C1
[[Category: Unreleased Structures]]
[[Category: Hui, Z]]
[[Category: Junyu, X]]