5yhh - Revision history

OCA at 08:30, 22 November 2023

OCA — Wed, 22 Nov 2023 08:30:03 GMT

←Older revision		Revision as of 08:30, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5yhh' size='340' side='right'caption='[[5yhh]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5yhh' size='340' side='right'caption='[[5yhh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yhh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5YHH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yhh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YHH FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5yhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhh OCA], [~~http~~://pdbe.org/5yhh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yhh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yhh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhh ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhh OCA], [https://pdbe.org/5yhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yhh RCSB], [https://www.ebi.ac.uk/pdbsum/5yhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A150NEL9_GEOSE A0A150NEL9_GEOSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Geobacillus stearothermophilus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kim~~, J H~~]]	+	[[Category: Kim JH]]
-	[[Category: Namgung, B]]	+	[[Category: Namgung B]]
-	[[Category: Song~~, W S~~]]	+	[[Category: Song WS]]
-	[[Category: Yoon~~, S I]]~~	+	[[Category: Yoon SI]]
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Mosc]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 09:19, 21 October 2020

OCA — Wed, 21 Oct 2020 09:19:30 GMT

←Older revision		Revision as of 09:19, 21 October 2020
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	==Crystal structure of YiiM from Geobacillus stearothermophilus==		==Crystal structure of YiiM from Geobacillus stearothermophilus==
-	<StructureSection load='5yhh' size='340' side='right' caption='[[5yhh]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5yhh' size='340' side='right'caption='[[5yhh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yhh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YHH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yhh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YHH FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhh OCA], [http://pdbe.org/5yhh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yhh RCSB], [http://www.ebi.ac.uk/pdbsum/5yhh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhh OCA], [http://pdbe.org/5yhh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yhh RCSB], [http://www.ebi.ac.uk/pdbsum/5yhh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kim, J H]]		[[Category: Kim, J H]]
	[[Category: Namgung, B]]		[[Category: Namgung, B]]

OCA at 05:05, 8 March 2018

OCA — Thu, 08 Mar 2018 05:05:27 GMT

←Older revision		Revision as of 05:05, 8 March 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5yhh is ~~ON HOLD~~	+	==Crystal structure of YiiM from Geobacillus stearothermophilus==
		+	<StructureSection load='5yhh' size='340' side='right' caption='[[5yhh]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5yhh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YHH FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhh OCA], [http://pdbe.org/5yhh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yhh RCSB], [http://www.ebi.ac.uk/pdbsum/5yhh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhh ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molybdenum cofactor (Moco) is a molybdenum-conjugated prosthetic group that is ubiquitously found in plants, animals, and bacteria. Moco is required for the nitrogen-reducing reaction of the Moco sulfurase C-terminal domain (MOSC) family. Despite the biological significance of MOSC proteins in the conversion of prodrugs and resistance against mutagens, their structural features and Moco-mediated catalysis mechanism have not been described in detail. YiiM is a MOSC protein that is involved in reducing mutagenic 6-N-hydroxylaminopurine to nontoxic adenine in bacteria. Here, we report two crystal structures of YiiM: one from Gram-positive Geobacillus stearothermophilus (gsYiiM) and the other from Gram-negative Escherichia coli (ecYiiM). Although gsYiiM and ecYiiM differ in oligomerization state and protein stability, both consist of three structural modules (a beta-barrel and two alpha-helix bundles) and feature a cavity surrounded by the three modules. The cavity is characterized by positive electrostatic potentials and high sequence conservation. Moreover, the ecYiiM cavity houses a phosphate group, which emulates a part of Moco, and contains a highly reactive invariant cysteine residue. We thus propose that the cavity is the catalytic site where Moco binds and the substrate is reduced. Moreover, our comparative structural analysis highlights the common but distinct structural features of MOSC proteins.

-	~~Authors~~:	+	Crystal structure of the hydroxylaminopurine resistance protein, YiiM, and its putative molybdenum cofactor-binding catalytic site.,Namgung B, Kim JH, Song WS, Yoon SI Sci Rep. 2018 Feb 19;8(1):3304. doi: 10.1038/s41598-018-21660-y. PMID:29459651<ref>PMID:29459651</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5yhh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kim, J H]]
		+	[[Category: Namgung, B]]
		+	[[Category: Song, W S]]
		+	[[Category: Yoon, S I]]
		+	[[Category: Enzyme]]
		+	[[Category: Mosc]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "5yhh" [edit=sysop:move=sysop]

OCA — Wed, 04 Oct 2017 08:07:08 GMT

Protected "5yhh" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:07, 4 October 2017

OCA: New page: '''Unreleased structure''' The entry 5yhh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Oct 2017 08:07:06 GMT

New page: '''Unreleased structure''' The entry 5yhh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5yhh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]