5yjg - Revision history

OCA at 08:31, 22 November 2023

OCA — Wed, 22 Nov 2023 08:31:57 GMT

←Older revision		Revision as of 08:31, 22 November 2023
Line 1:		Line 1:

	==Structural insights into periostin functions==		==Structural insights into periostin functions==
-	<StructureSection load='5yjg' size='340' side='right' caption='[[5yjg]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5yjg' size='340' side='right'caption='[[5yjg]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yjg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YJG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YJG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yjg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YJG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.399Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POSTN, OSF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yjg OCA], [~~http~~://pdbe.org/5yjg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yjg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yjg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yjg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yjg OCA], [https://pdbe.org/5yjg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yjg RCSB], [https://www.ebi.ac.uk/pdbsum/5yjg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yjg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/POSTN_HUMAN POSTN_HUMAN]] Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).[UniProtKB:Q62009]<ref>PMID:12235007</ref>	+	[https://www.uniprot.org/uniprot/POSTN_HUMAN POSTN_HUMAN] Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).[UniProtKB:Q62009]<ref>PMID:12235007</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Liu, H~~]]	+	[[Category: Large Structures]]
-	[[Category: Liu~~, J~~]]	+	[[Category: Liu H]]
-	[[Category: ~~Xu, F~~]]	+	[[Category: Liu J]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Xu F]]
-	~~[[Category: Tissue regeneration~~]]	+

OCA at 08:06, 14 June 2018

OCA — Thu, 14 Jun 2018 08:06:30 GMT

←Older revision		Revision as of 08:06, 14 June 2018
Line 3:		Line 3:
	<StructureSection load='5yjg' size='340' side='right' caption='[[5yjg]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5yjg' size='340' side='right' caption='[[5yjg]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yjg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YJG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yjg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YJG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POSTN, OSF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yjg OCA], [http://pdbe.org/5yjg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yjg RCSB], [http://www.ebi.ac.uk/pdbsum/5yjg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yjg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yjg OCA], [http://pdbe.org/5yjg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yjg RCSB], [http://www.ebi.ac.uk/pdbsum/5yjg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yjg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/POSTN_HUMAN POSTN_HUMAN]] Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).[UniProtKB:Q62009]<ref>PMID:12235007</ref>		[[http://www.uniprot.org/uniprot/POSTN_HUMAN POSTN_HUMAN]] Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).[UniProtKB:Q62009]<ref>PMID:12235007</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human periostin plays a multifaceted role in remodeling the extracellular matrix milieu by interacting with other proteins and itself in both a heterophilic and homophilic manner. However, the structural mechanism for its extensive interactions has remained elusive. Here, we report the crystal structures of human periostin (EMI-Fas1(I-)(IV) ) and its Cys60Ala mutant. In combination with multi-angle light-scattering analysis and biochemical assays, the crystal structures reveal that periostin mainly exists as a dimer in solution and its homophilic interaction is mainly mediated by the EMI domain. Furthermore, Cys60 undergoes cysteinylation as confirmed by mass spectroscopy, and this site hardly affects the homophilic interaction. Also, the structures yield insights into how periostin forms heterophilic interactions with other proteins under physiological or pathological conditions.
		+
		+	Structural characterizations of human periostin dimerization and cysteinylation.,Liu J, Zhang J, Xu F, Lin Z, Li Z, Liu H FEBS Lett. 2018 Jun;592(11):1789-1803. doi: 10.1002/1873-3468.13091. Epub 2018, May 21. PMID:29754429<ref>PMID:29754429</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5yjg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Liu, H]]		[[Category: Liu, H]]
	[[Category: Liu, J]]		[[Category: Liu, J]]

OCA at 07:17, 23 May 2018

OCA — Wed, 23 May 2018 07:17:58 GMT

←Older revision		Revision as of 07:17, 23 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5yjg is ~~ON HOLD until Paper Publication~~	+	==Structural insights into periostin functions==
-		+	<StructureSection load='5yjg' size='340' side='right' caption='[[5yjg]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~: ~~Liu~~, H., ~~Liu~~, J., Xu, F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5yjg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YJG FirstGlance]. <br>
-	~~Description: Structural insights into periostin functions~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yjg OCA], [http://pdbe.org/5yjg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yjg RCSB], [http://www.ebi.ac.uk/pdbsum/5yjg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yjg ProSAT]</span></td></tr>
-	~~[[Category~~: Xu, F]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/POSTN_HUMAN POSTN_HUMAN]] Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).[UniProtKB:Q62009]<ref>PMID:12235007</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Liu, H]]		[[Category: Liu, H]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
		+	[[Category: Xu, F]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Tissue regeneration]]

OCA: Protected "5yjg" [edit=sysop:move=sysop]

OCA — Wed, 08 Nov 2017 06:24:47 GMT

Protected "5yjg" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:24, 8 November 2017

OCA: New page: '''Unreleased structure''' The entry 5yjg is ON HOLD until Paper Publication Authors: Liu, H., Liu, J., Xu, F. Description: Structural insights into periostin functions [[Category: Unr...

OCA — Wed, 08 Nov 2017 06:24:46 GMT

New page: '''Unreleased structure''' The entry 5yjg is ON HOLD until Paper Publication Authors: Liu, H., Liu, J., Xu, F. Description: Structural insights into periostin functions [[Category: Unr...

New page

'''Unreleased structure'''

The entry 5yjg is ON HOLD until Paper Publication

Authors: Liu, H., Liu, J., Xu, F.

Description: Structural insights into periostin functions
[[Category: Unreleased Structures]]
[[Category: Xu, F]]
[[Category: Liu, H]]
[[Category: Liu, J]]