5ykg - Revision history

OCA at 22:44, 10 April 2020

OCA — Fri, 10 Apr 2020 22:44:12 GMT

←Older revision		Revision as of 22:44, 10 April 2020
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	<SX load='5ykg' size='340' side='right' viewer='molstar' caption='[[5ykg]], [[Resolution\|resolution]] 4.57Å' scene=''>		<SX load='5ykg' size='340' side='right' viewer='molstar' caption='[[5ykg]], [[Resolution\|resolution]] 4.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ykg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ykg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YKG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=GBM:5-CHLORO-N-(2-{4-[(CYCLOHEXYLCARBAMOYL)SULFAMOYL]PHENYL}ETHYL)-2-METHOXYBENZAMIDE'>GBM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=GBM:5-CHLORO-N-(2-{4-[(CYCLOHEXYLCARBAMOYL)SULFAMOYL]PHENYL}ETHYL)-2-METHOXYBENZAMIDE'>GBM</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kcnj11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Abcc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Golden hamster])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kcnj11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Abcc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Golden hamster])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ykg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykg OCA], [http://pdbe.org/5ykg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ykg RCSB], [http://www.ebi.ac.uk/pdbsum/5ykg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ykg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykg OCA], [http://pdbe.org/5ykg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ykg RCSB], [http://www.ebi.ac.uk/pdbsum/5ykg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:14, 6 March 2020

OCA — Fri, 06 Mar 2020 20:14:17 GMT

←Older revision		Revision as of 20:14, 6 March 2020
Line 1:		Line 1:

	==Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)==		==Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)==
-	<~~StructureSection~~ load='5ykg' size='340' side='right' caption='[[5ykg]], [[Resolution\|resolution]] 4.57Å' scene=''>	+	<SX load='5ykg' size='340' side='right' viewer='molstar' caption='[[5ykg]], [[Resolution\|resolution]] 4.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ykg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YKG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ykg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YKG FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5ykg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ykg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Golden hamster]]		[[Category: Golden hamster]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Chen, L]]		[[Category: Chen, L]]

OCA at 08:07, 14 June 2018

OCA — Thu, 14 Jun 2018 08:07:17 GMT

←Older revision		Revision as of 08:07, 14 June 2018
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	<StructureSection load='5ykg' size='340' side='right' caption='[[5ykg]], [[Resolution\|resolution]] 4.57Å' scene=''>		<StructureSection load='5ykg' size='340' side='right' caption='[[5ykg]], [[Resolution\|resolution]] 4.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ykg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YKG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ykg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YKG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=GBM:5-CHLORO-N-(2-{4-[(CYCLOHEXYLCARBAMOYL)SULFAMOYL]PHENYL}ETHYL)-2-METHOXYBENZAMIDE'>GBM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=GBM:5-CHLORO-N-(2-{4-[(CYCLOHEXYLCARBAMOYL)SULFAMOYL]PHENYL}ETHYL)-2-METHOXYBENZAMIDE'>GBM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kcnj11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Abcc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Golden hamster])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ykg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykg OCA], [http://pdbe.org/5ykg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ykg RCSB], [http://www.ebi.ac.uk/pdbsum/5ykg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ykg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykg OCA], [http://pdbe.org/5ykg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ykg RCSB], [http://www.ebi.ac.uk/pdbsum/5ykg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykg ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Golden hamster]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Wu, J X]]		[[Category: Wu, J X]]

OCA at 05:41, 18 April 2018

OCA — Wed, 18 Apr 2018 05:41:56 GMT

←Older revision		Revision as of 05:41, 18 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ykg is ~~ON HOLD~~	+	==Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)==
		+	<StructureSection load='5ykg' size='340' side='right' caption='[[5ykg]], [[Resolution\|resolution]] 4.57Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ykg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YKG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=GBM:5-CHLORO-N-(2-{4-[(CYCLOHEXYLCARBAMOYL)SULFAMOYL]PHENYL}ETHYL)-2-METHOXYBENZAMIDE'>GBM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ykg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykg OCA], [http://pdbe.org/5ykg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ykg RCSB], [http://www.ebi.ac.uk/pdbsum/5ykg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KCJ11_MOUSE KCJ11_MOUSE]] This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of beta-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and diseases and are therefore important drug targets. Here, we present three structures of pancreatic KATP channels solved by cryo-electron microscopy (cryo-EM), at resolutions ranging from 4.1 to 4.5 A. These structures depict the binding site of the antidiabetic drug glibenclamide, indicate how Kir6.2 (inward-rectifying potassium channel 6.2) N-terminus participates in the coupling between the peripheral SUR1 (sulfonylurea receptor 1) subunit and the central Kir6.2 channel, reveal the binding mode of activating nucleotides, and suggest the mechanism of how Mg-ADP binding on nucleotide binding domains (NBDs) drives a conformational change of the SUR1 subunit.

-	~~Authors~~:	+	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.,Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L Protein Cell. 2018 Mar 28. pii: 10.1007/s13238-018-0530-y. doi:, 10.1007/s13238-018-0530-y. PMID:29594720<ref>PMID:29594720</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ykg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, L]]
		+	[[Category: Wu, J X]]
		+	[[Category: Channel]]
		+	[[Category: Glibenclamide]]
		+	[[Category: Katp]]
		+	[[Category: Membrane protein]]
		+	[[Category: Sulfonylurea]]

OCA at 06:24, 22 November 2017

OCA — Wed, 22 Nov 2017 06:24:04 GMT

←Older revision		Revision as of 06:24, 22 November 2017
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	The entry 5ykg is ON HOLD		The entry 5ykg is ON HOLD

-	Authors: ~~Chen, L., Wu, J.X.~~	+	Authors:

-	Description: ~~Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Wu, J.X]]
-	[[Category: Chen, L]]

OCA: Protected "5ykg" [edit=sysop:move=sysop]

OCA — Wed, 25 Oct 2017 05:37:51 GMT

Protected "5ykg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 25 October 2017

OCA: New page: '''Unreleased structure''' The entry 5ykg is ON HOLD Authors: Chen, L., Wu, J.X. Description: Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPga...

OCA — Wed, 25 Oct 2017 05:37:50 GMT

New page: '''Unreleased structure''' The entry 5ykg is ON HOLD Authors: Chen, L., Wu, J.X. Description: Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPga...

New page

'''Unreleased structure'''

The entry 5ykg is ON HOLD

Authors: Chen, L., Wu, J.X.

Description: Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
[[Category: Unreleased Structures]]
[[Category: Wu, J.X]]
[[Category: Chen, L]]