5yl2 - Revision history

OCA at 10:23, 27 March 2024

OCA — Wed, 27 Mar 2024 10:23:58 GMT

←Older revision		Revision as of 10:23, 27 March 2024
Line 1:		Line 1:

	==Crystal structure of T2R-TTL-Y28 complex==		==Crystal structure of T2R-TTL-Y28 complex==
-	<StructureSection load='5yl2' size='340' side='right' caption='[[5yl2]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='5yl2' size='340' side='right'caption='[[5yl2]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yl2]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~], [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~] and [~~http~~://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YL2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YL2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yl2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YL2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8WU:(E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one'>8WU</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.09Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TUBA1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG]), TUBB2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG]), Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8WU:(E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one'>8WU</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yl2 OCA], [~~http~~://pdbe.org/5yl2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yl2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yl2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yl2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yl2 OCA], [https://pdbe.org/5yl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yl2 RCSB], [https://www.ebi.ac.uk/pdbsum/5yl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yl2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/A0A287AGU7_PIG A0A287AGU7_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00031082]	+	[https://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Inhibitors that bind to the paclitaxel- or vinblastine-binding sites of tubulin have been part of the pharmacopoeia of anticancer therapy for decades. However, tubulin inhibitors that bind to the colchicine-binding site are not used in clinical cancer therapy, because of their low therapeutic index. To address multidrug resistance to many conventional tubulin-binding agents, numerous efforts have attempted to clinically develop inhibitors that bind the colchicine-binding site. Previously, we have found that millepachine (MIL), a natural chalcone-type small molecule extracted from the plant Millettia pachycarpa, and its two derivatives (MDs) SKLB028 and SKLB050 have potential antitumor activities both in vitro and in vivo. However, their cellular targets and mechanisms are unclear. Here, biochemical and cellular experiments revealed that the MDs directly and irreversibly bind beta-tubulin. X-ray crystallography of the tubulin-MD structures disclosed that the MDs bind at the tubulin intradimer interface and to the same site as colchicine and that their binding mode is similar to that of colchicine. Of note, MDs inhibited tubulin polymerization and caused G2/M cell cycle arrest. Comprehensive analysis further revealed that free MIL exhibits an s-cis conformation, whereas MIL in the colchicine-binding site in tubulin adopts an s-trans conformation. Moreover, introducing an alpha-methyl to MDs in order to increase the proportion of s-trans conformations augmented MDs' tubulin inhibition activity. Our study uncovers a new class of chalcone-type tubulin inhibitors that bind the colchicine-binding site in beta-tubulin and suggests that the s-trans conformation of these compounds may make them more active anticancer agents.	+

-	The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.,Jianhong Y, Wei Y, Yamei Y, Yuxi W, Tao Y, Linlin X, Xue Y, Caofeng L, Zuowei L, Xiaoxin C, Mengshi H, Li Z, Qiang Q, Heying P, Dan L, Fang W, Peng B, Jiaolin W, Haoyu Y Sr., Lijuan C J Biol Chem. 2018 Apr 24. pii: RA117.001658. doi: 10.1074/jbc.RA117.001658. PMID:29691282<ref>PMID:29691282</ref>	+	==See Also==
-		+	*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 5yl2" style~~=~~"background-color:#fffaf0;"></div>~~	+
-	~~== References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Gallus gallus]]
-	[[Category: ~~Chick~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pig~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Chen, L J~~]]	+	[[Category: Sus scrofa]]
-	[[Category: ~~Wen, J L~~]]	+	[[Category: Chen LJ]]
-	[[Category: ~~Yang, J H~~]]	+	[[Category: Wen JL]]
-	[[Category: Yang~~, T~~]]	+	[[Category: Yang JH]]
-	[[Category: ~~Colchicine binding domain]]~~	+	[[Category: Yang T]]
-	~~[[Category: Millepachine]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Tublin]]~~	+
-	~~[[Category: Tubulin inhibitor~~]]	+

OCA at 07:42, 23 May 2018

OCA — Wed, 23 May 2018 07:42:57 GMT

←Older revision		Revision as of 07:42, 23 May 2018
Line 3:		Line 3:
	<StructureSection load='5yl2' size='340' side='right' caption='[[5yl2]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='5yl2' size='340' side='right' caption='[[5yl2]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yl2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YL2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yl2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat], [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YL2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8WU:(E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one'>8WU</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8WU:(E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one'>8WU</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TUBA1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG]), TUBB2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG]), Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yl2 OCA], [http://pdbe.org/5yl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yl2 RCSB], [http://www.ebi.ac.uk/pdbsum/5yl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yl2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yl2 OCA], [http://pdbe.org/5yl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yl2 RCSB], [http://www.ebi.ac.uk/pdbsum/5yl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yl2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/A0A287AGU7_PIG A0A287AGU7_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00031082]		[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/A0A287AGU7_PIG A0A287AGU7_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00031082]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibitors that bind to the paclitaxel- or vinblastine-binding sites of tubulin have been part of the pharmacopoeia of anticancer therapy for decades. However, tubulin inhibitors that bind to the colchicine-binding site are not used in clinical cancer therapy, because of their low therapeutic index. To address multidrug resistance to many conventional tubulin-binding agents, numerous efforts have attempted to clinically develop inhibitors that bind the colchicine-binding site. Previously, we have found that millepachine (MIL), a natural chalcone-type small molecule extracted from the plant Millettia pachycarpa, and its two derivatives (MDs) SKLB028 and SKLB050 have potential antitumor activities both in vitro and in vivo. However, their cellular targets and mechanisms are unclear. Here, biochemical and cellular experiments revealed that the MDs directly and irreversibly bind beta-tubulin. X-ray crystallography of the tubulin-MD structures disclosed that the MDs bind at the tubulin intradimer interface and to the same site as colchicine and that their binding mode is similar to that of colchicine. Of note, MDs inhibited tubulin polymerization and caused G2/M cell cycle arrest. Comprehensive analysis further revealed that free MIL exhibits an s-cis conformation, whereas MIL in the colchicine-binding site in tubulin adopts an s-trans conformation. Moreover, introducing an alpha-methyl to MDs in order to increase the proportion of s-trans conformations augmented MDs' tubulin inhibition activity. Our study uncovers a new class of chalcone-type tubulin inhibitors that bind the colchicine-binding site in beta-tubulin and suggests that the s-trans conformation of these compounds may make them more active anticancer agents.
		+
		+	The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.,Jianhong Y, Wei Y, Yamei Y, Yuxi W, Tao Y, Linlin X, Xue Y, Caofeng L, Zuowei L, Xiaoxin C, Mengshi H, Li Z, Qiang Q, Heying P, Dan L, Fang W, Peng B, Jiaolin W, Haoyu Y Sr., Lijuan C J Biol Chem. 2018 Apr 24. pii: RA117.001658. doi: 10.1074/jbc.RA117.001658. PMID:29691282<ref>PMID:29691282</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5yl2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Chick]]
		+	[[Category: Pig]]
	[[Category: Chen, L J]]		[[Category: Chen, L J]]
	[[Category: Wen, J L]]		[[Category: Wen, J L]]

OCA at 05:42, 18 April 2018

OCA — Wed, 18 Apr 2018 05:42:08 GMT

←Older revision		Revision as of 05:42, 18 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5yl2 is ~~ON HOLD~~	+	==Crystal structure of T2R-TTL-Y28 complex==
-		+	<StructureSection load='5yl2' size='340' side='right' caption='[[5yl2]], [[Resolution\|resolution]] 2.09Å' scene=''>
-	~~Authors~~: ~~Yang~~, J.H., ~~Yang~~, T., ~~Wen, J~~.L., ~~Chen, L~~.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5yl2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YL2 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~T2R~~-~~TTL~~-~~Y28 complex~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8WU:(E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one'>8WU</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yl2 OCA], [http://pdbe.org/5yl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yl2 RCSB], [http://www.ebi.ac.uk/pdbsum/5yl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yl2 ProSAT]</span></td></tr>
-	[[Category: ~~Wen~~, J.L]]	+	</table>
-	[[Category: ~~Yang~~, J.H]]	+	== Function ==
-	[[Category: ~~Chen~~, L.J]]	+	[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/A0A287AGU7_PIG A0A287AGU7_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00031082]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, L J]]
		+	[[Category: Wen, J L]]
		+	[[Category: Yang, J H]]
	[[Category: Yang, T]]		[[Category: Yang, T]]
		+	[[Category: Colchicine binding domain]]
		+	[[Category: Millepachine]]
		+	[[Category: Structural protein]]
		+	[[Category: Tublin]]
		+	[[Category: Tubulin inhibitor]]

OCA: Protected "5yl2" [edit=sysop:move=sysop]

OCA — Wed, 25 Oct 2017 05:39:25 GMT

Protected "5yl2" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:39, 25 October 2017

OCA: New page: '''Unreleased structure''' The entry 5yl2 is ON HOLD Authors: Yang, J.H., Yang, T., Wen, J.L., Chen, L.J. Description: Crystal structure of T2R-TTL-Y28 complex [[Category: Unreleased S...

OCA — Wed, 25 Oct 2017 05:39:24 GMT

New page: '''Unreleased structure''' The entry 5yl2 is ON HOLD Authors: Yang, J.H., Yang, T., Wen, J.L., Chen, L.J. Description: Crystal structure of T2R-TTL-Y28 complex [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 5yl2 is ON HOLD

Authors: Yang, J.H., Yang, T., Wen, J.L., Chen, L.J.

Description: Crystal structure of T2R-TTL-Y28 complex
[[Category: Unreleased Structures]]
[[Category: Wen, J.L]]
[[Category: Yang, J.H]]
[[Category: Chen, L.J]]
[[Category: Yang, T]]