5yt9 - Revision history

OCA at 08:37, 22 November 2023

OCA — Wed, 22 Nov 2023 08:37:13 GMT

←Older revision		Revision as of 08:37, 22 November 2023
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	==Crystal structure of H5 hemagglutinin G228S mutant from A/chicken/Taiwan/0502/2012==		==Crystal structure of H5 hemagglutinin G228S mutant from A/chicken/Taiwan/0502/2012==
-	<StructureSection load='5yt9' size='340' side='right'caption='[[5yt9]]' scene=''>	+	<StructureSection load='5yt9' size='340' side='right'caption='[[5yt9]], [[Resolution\|resolution]] 2.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YT9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5YT9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yt9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/chicken/Taiwan/0502/2012(H5N2)) Influenza A virus (A/chicken/Taiwan/0502/2012(H5N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YT9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5yt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yt9 OCA], [~~http~~://pdbe.org/5yt9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yt9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yt9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yt9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.766Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yt9 OCA], [https://pdbe.org/5yt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yt9 RCSB], [https://www.ebi.ac.uk/pdbsum/5yt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yt9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A059VBQ9_9INFA A0A059VBQ9_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072][SAAS:SAAS01039073] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]

	==See Also==		==See Also==

OCA at 09:27, 21 October 2020

OCA — Wed, 21 Oct 2020 09:27:20 GMT

←Older revision		Revision as of 09:27, 21 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 5yt9 is ~~ON HOLD~~	+	==Crystal structure of H5 hemagglutinin G228S mutant from A/chicken/Taiwan/0502/2012==
		+	<StructureSection load='5yt9' size='340' side='right'caption='[[5yt9]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YT9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YT9 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yt9 OCA], [http://pdbe.org/5yt9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yt9 RCSB], [http://www.ebi.ac.uk/pdbsum/5yt9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yt9 ProSAT]</span></td></tr>
		+	</table>

-	~~Authors: Lin, T.H., Lee, M.S., Wu, W.G., Liu, J.S.~~	+	==See Also==
-		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
-	~~Description: Crystal structure of H5 hemagglutinin G228S mutant from A/chicken/Taiwan/0502~~/~~2012~~	+	__TOC__
-	[[Category: ~~Unreleased~~ Structures]]	+	</StructureSection>
-	[[Category: ~~Lin, T.H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Liu, J.S~~]]	+	[[Category: Lee MS]]
-	[[Category: ~~Wu, W.G~~]]	+	[[Category: Lin TH]]
-	[[Category: ~~Lee, M.S~~]]	+	[[Category: Liu JS]]
		+	[[Category: Wu WG]]

OCA: Protected "5yt9" [edit=sysop:move=sysop]

OCA — Wed, 22 Nov 2017 06:29:36 GMT

Protected "5yt9" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:29, 22 November 2017

OCA: New page: '''Unreleased structure''' The entry 5yt9 is ON HOLD Authors: Lin, T.H., Lee, M.S., Wu, W.G., Liu, J.S. Description: Crystal structure of H5 hemagglutinin G228S mutant from A/chicken/T...

OCA — Wed, 22 Nov 2017 06:29:35 GMT

New page: '''Unreleased structure''' The entry 5yt9 is ON HOLD Authors: Lin, T.H., Lee, M.S., Wu, W.G., Liu, J.S. Description: Crystal structure of H5 hemagglutinin G228S mutant from A/chicken/T...

New page

'''Unreleased structure'''

The entry 5yt9 is ON HOLD

Authors: Lin, T.H., Lee, M.S., Wu, W.G., Liu, J.S.

Description: Crystal structure of H5 hemagglutinin G228S mutant from A/chicken/Taiwan/0502/2012
[[Category: Unreleased Structures]]
[[Category: Lin, T.H]]
[[Category: Liu, J.S]]
[[Category: Wu, W.G]]
[[Category: Lee, M.S]]