5ywd - Revision history

OCA at 10:25, 27 March 2024

OCA — Wed, 27 Mar 2024 10:25:32 GMT

←Older revision		Revision as of 10:25, 27 March 2024
Line 3:		Line 3:
	<SX load='5ywd' size='340' side='right' viewer='molstar' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>		<SX load='5ywd' size='340' side='right' viewer='molstar' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Golden_hamster Golden hamster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5YWD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YWD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Abcc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id~~=~~10036 Golden hamster])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywd OCA], [~~http~~://pdbe.org/5ywd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ywd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ywd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywd OCA], [https://pdbe.org/5ywd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ywd RCSB], [https://www.ebi.ac.uk/pdbsum/5ywd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywd ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/A0A1U7R319_MESAU A0A1U7R319_MESAU]
-	ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of beta-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and diseases and are therefore important drug targets. Here, we present three structures of pancreatic KATP channels solved by cryo-electron microscopy (cryo-EM), at resolutions ranging from 4.1 to 4.5 A. These structures depict the binding site of the antidiabetic drug glibenclamide, indicate how Kir6.2 (inward-rectifying potassium channel 6.2) N-terminus participates in the coupling between the peripheral SUR1 (sulfonylurea receptor 1) subunit and the central Kir6.2 channel, reveal the binding mode of activating nucleotides, and suggest the mechanism of how Mg-ADP binding on nucleotide binding domains (NBDs) drives a conformational change of the SUR1 subunit.	+
-		+
-	~~Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.,Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L Protein Cell. 2018 Mar 28. pii~~: ~~10.1007~~/~~s13238-018-0530-y. doi:, 10.1007~~/~~s13238-018-0530-y~~. ~~PMID:29594720<ref>PMID:29594720</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.~~S. National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 5ywd" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Golden hamster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, L~~]]	+	[[Category: Mesocricetus auratus]]
-	[[Category: ~~Wu, J X~~]]	+	[[Category: Chen L]]
-	[[Category: ~~Channel]]~~	+	[[Category: Wu JX]]
-	~~[[Category: Glibenclamide]]~~	+
-	~~[[Category: Katp]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Sulfonylurea~~]]	+

OCA at 22:46, 10 April 2020

OCA — Fri, 10 Apr 2020 22:46:15 GMT

←Older revision		Revision as of 22:46, 10 April 2020
Line 3:		Line 3:
	<SX load='5ywd' size='340' side='right' viewer='molstar' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>		<SX load='5ywd' size='340' side='right' viewer='molstar' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YWD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YWD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Golden hamster])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Golden hamster])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywd OCA], [http://pdbe.org/5ywd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywd RCSB], [http://www.ebi.ac.uk/pdbsum/5ywd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywd OCA], [http://pdbe.org/5ywd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywd RCSB], [http://www.ebi.ac.uk/pdbsum/5ywd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:15, 6 March 2020

OCA — Fri, 06 Mar 2020 20:15:13 GMT

←Older revision		Revision as of 20:15, 6 March 2020
Line 1:		Line 1:

	==Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A)==		==Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A)==
-	<~~StructureSection~~ load='5ywd' size='340' side='right' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>	+	<SX load='5ywd' size='340' side='right' viewer='molstar' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWD FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Golden hamster]]		[[Category: Golden hamster]]
		+	[[Category: Large Structures]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Wu, J X]]		[[Category: Wu, J X]]

OCA at 08:08, 14 June 2018

OCA — Thu, 14 Jun 2018 08:08:15 GMT

←Older revision		Revision as of 08:08, 14 June 2018
Line 3:		Line 3:
	<StructureSection load='5ywd' size='340' side='right' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>		<StructureSection load='5ywd' size='340' side='right' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Golden_hamster Golden hamster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10036 Golden hamster])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywd OCA], [http://pdbe.org/5ywd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywd RCSB], [http://www.ebi.ac.uk/pdbsum/5ywd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywd OCA], [http://pdbe.org/5ywd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywd RCSB], [http://www.ebi.ac.uk/pdbsum/5ywd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywd ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Golden hamster]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Wu, J X]]		[[Category: Wu, J X]]

OCA at 08:07, 2 May 2018

OCA — Wed, 02 May 2018 08:07:09 GMT

←Older revision		Revision as of 08:07, 2 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ywd is ~~ON HOLD~~	+	==Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A)==
		+	<StructureSection load='5ywd' size='340' side='right' caption='[[5ywd]], [[Resolution\|resolution]] 4.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ywd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YWD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ywd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ywd OCA], [http://pdbe.org/5ywd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ywd RCSB], [http://www.ebi.ac.uk/pdbsum/5ywd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ywd ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATP-sensitive potassium channels (KATP) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of beta-cells, pancreatic KATP channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and diseases and are therefore important drug targets. Here, we present three structures of pancreatic KATP channels solved by cryo-electron microscopy (cryo-EM), at resolutions ranging from 4.1 to 4.5 A. These structures depict the binding site of the antidiabetic drug glibenclamide, indicate how Kir6.2 (inward-rectifying potassium channel 6.2) N-terminus participates in the coupling between the peripheral SUR1 (sulfonylurea receptor 1) subunit and the central Kir6.2 channel, reveal the binding mode of activating nucleotides, and suggest the mechanism of how Mg-ADP binding on nucleotide binding domains (NBDs) drives a conformational change of the SUR1 subunit.

-	~~Authors~~:	+	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.,Wu JX, Ding D, Wang M, Kang Y, Zeng X, Chen L Protein Cell. 2018 Mar 28. pii: 10.1007/s13238-018-0530-y. doi:, 10.1007/s13238-018-0530-y. PMID:29594720<ref>PMID:29594720</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ywd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, L]]
		+	[[Category: Wu, J X]]
		+	[[Category: Channel]]
		+	[[Category: Glibenclamide]]
		+	[[Category: Katp]]
		+	[[Category: Membrane protein]]
		+	[[Category: Sulfonylurea]]

OCA: Protected "5ywd" [edit=sysop:move=sysop]

OCA — Wed, 06 Dec 2017 06:00:07 GMT

Protected "5ywd" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 6 December 2017

OCA: New page: '''Unreleased structure''' The entry 5ywd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Dec 2017 06:00:05 GMT

New page: '''Unreleased structure''' The entry 5ywd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5ywd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]