5yz0 - Revision history

OCA at 22:47, 10 April 2020

OCA — Fri, 10 Apr 2020 22:47:21 GMT

←Older revision		Revision as of 22:47, 10 April 2020
Line 3:		Line 3:
	<SX load='5yz0' size='340' side='right' viewer='molstar' caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>		<SX load='5yz0' size='340' side='right' viewer='molstar' caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATR, FRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ATRIP, AGS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATR, FRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ATRIP, AGS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yz0 OCA], [http://pdbe.org/5yz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yz0 RCSB], [http://www.ebi.ac.uk/pdbsum/5yz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yz0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yz0 OCA], [http://pdbe.org/5yz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yz0 RCSB], [http://www.ebi.ac.uk/pdbsum/5yz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yz0 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 20:15, 6 March 2020

OCA — Fri, 06 Mar 2020 20:15:41 GMT

←Older revision		Revision as of 20:15, 6 March 2020
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	==Cryo-EM Structure of human ATR-ATRIP complex==		==Cryo-EM Structure of human ATR-ATRIP complex==
-	<~~StructureSection~~ load='5yz0' size='340' side='right'caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>	+	<SX load='5yz0' size='340' side='right' viewer='molstar' caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5yz0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5yz0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:30, 6 November 2019

OCA — Wed, 06 Nov 2019 07:30:17 GMT

←Older revision		Revision as of 07:30, 6 November 2019
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	==Cryo-EM Structure of human ATR-ATRIP complex==		==Cryo-EM Structure of human ATR-ATRIP complex==
-	<StructureSection load='5yz0' size='340' side='right' caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>	+	<StructureSection load='5yz0' size='340' side='right'caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Liu, M]]		[[Category: Liu, M]]

OCA at 08:00, 21 March 2018

OCA — Wed, 21 Mar 2018 08:00:41 GMT

←Older revision		Revision as of 08:00, 21 March 2018
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	<StructureSection load='5yz0' size='340' side='right' caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>		<StructureSection load='5yz0' size='340' side='right' caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATR, FRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ATRIP, AGS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yz0 OCA], [http://pdbe.org/5yz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yz0 RCSB], [http://www.ebi.ac.uk/pdbsum/5yz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yz0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yz0 OCA], [http://pdbe.org/5yz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yz0 RCSB], [http://www.ebi.ac.uk/pdbsum/5yz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yz0 ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Liu, M]]		[[Category: Liu, M]]

OCA at 05:55, 31 January 2018

OCA — Wed, 31 Jan 2018 05:55:43 GMT

←Older revision		Revision as of 05:55, 31 January 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~5yz0~~ is ~~ON HOLD~~	+	==Cryo-EM Structure of human ATR-ATRIP complex==
		+	<StructureSection load='5yz0' size='340' side='right' caption='[[5yz0]], [[Resolution\|resolution]] 4.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5yz0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YZ0 FirstGlance]. <br>
		+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yz0 OCA], [http://pdbe.org/5yz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yz0 RCSB], [http://www.ebi.ac.uk/pdbsum/5yz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yz0 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ATR_HUMAN ATR_HUMAN]] Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome;Seckel syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/ATRIP_HUMAN ATRIP_HUMAN]] Seckel syndrome.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATR_HUMAN ATR_HUMAN]] Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.<ref>PMID:10597277</ref> <ref>PMID:10608806</ref> <ref>PMID:10859164</ref> <ref>PMID:11114888</ref> <ref>PMID:11418864</ref> <ref>PMID:11673449</ref> <ref>PMID:11721054</ref> <ref>PMID:11865061</ref> <ref>PMID:12526805</ref> <ref>PMID:12791985</ref> <ref>PMID:12814551</ref> <ref>PMID:14657349</ref> <ref>PMID:14729973</ref> <ref>PMID:14742437</ref> <ref>PMID:15210935</ref> <ref>PMID:15314022</ref> <ref>PMID:15496423</ref> <ref>PMID:16260606</ref> <ref>PMID:21144835</ref> <ref>PMID:27723717</ref> <ref>PMID:27723720</ref> <ref>PMID:9427750</ref> <ref>PMID:9636169</ref> <ref>PMID:9925639</ref> [[http://www.uniprot.org/uniprot/ATRIP_HUMAN ATRIP_HUMAN]] Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.<ref>PMID:12791985</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATR (ataxia telangiectasia-mutated and Rad3-related) protein kinase and ATRIP (ATR-interacting protein) form a complex and play a critical role in response to replication stress and DNA damage. Here, we determined the cryo-electron microscopy (EM) structure of the human ATR-ATRIP complex at 4.7 A resolution and built an atomic model of the C-terminal catalytic core of ATR (residues 1 521-2 644) at 3.9 A resolution. The complex adopts a hollow "heart" shape, consisting of two ATR monomers in distinct conformations. The EM map for ATRIP reveals 14 HEAT repeats in an extended "S" shape. The conformational flexibility of ATR allows ATRIP to properly lock the N-termini of the two ATR monomers to favor ATR-ATRIP complex formation and functional diversity. The isolated "head-head" and "tail-tail" each adopts a pseudo 2-fold symmetry. The catalytic pockets face outward and substrate access is not restricted by inhibitory elements. Our studies provide a structural basis for understanding the assembly of the ATR-ATRIP complex and a framework for characterizing ATR-mediated DNA repair pathways.Cell Research advance online publication 22 December 2017; doi:10.1038/cr.2017.158.

-	~~Authors:~~ Rao, Q., Liu, M., Tian, Y., Wu, Z., ~~Wang~~, H., Wang, J., Xu, Y.	+	Cryo-EM structure of human ATR-ATRIP complex.,Rao Q, Liu M, Tian Y, Wu Z, Hao Y, Song L, Qin Z, Ding C, Wang HW, Wang J, Xu Y Cell Res. 2017 Dec 22. pii: cr2017158. doi: 10.1038/cr.2017.158. PMID:29271416<ref>PMID:29271416</ref>

-	~~Description: Cryo-EM Structure~~ of ~~human ATR-ATRIP complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Wu, Z]]~~	+	<div class="pdbe-citations 5yz0" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Wang, H~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Liu, M]]		[[Category: Liu, M]]
-	[[Category: ~~Wang~~, J]]	+	[[Category: Rao, Q]]
	[[Category: Tian, Y]]		[[Category: Tian, Y]]
		+	[[Category: Wang, H]]
		+	[[Category: Wang, J]]
		+	[[Category: Wu, Z]]
	[[Category: Xu, Y]]		[[Category: Xu, Y]]
-	[[Category: ~~Rao, Q~~]]	+	[[Category: Atr-atrip]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cryo-em]]
		+	[[Category: Dna damnage response]]

OCA at 04:50, 3 January 2018

OCA — Wed, 03 Jan 2018 04:50:29 GMT

←Older revision		Revision as of 04:50, 3 January 2018
Line 3:		Line 3:
	The entry 5yz0 is ON HOLD		The entry 5yz0 is ON HOLD

-	Authors: ~~Qinhui~~, R., ~~Mengjie~~, L., ~~Yuan~~, T., ~~Zihan~~, W., ~~Hongwei~~, W., ~~Jiawei~~, W., ~~Yanhui~~, X.	+	Authors: Rao, Q., Liu, M., Tian, Y., Wu, Z., Wang, H., Wang, J., Xu, Y.

	Description: Cryo-EM Structure of human ATR-ATRIP complex		Description: Cryo-EM Structure of human ATR-ATRIP complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Jiawei~~, W]]	+	[[Category: Wu, Z]]
-	[[Category: ~~Mengjie~~, L]]	+	[[Category: Wang, H]]
-	[[Category: ~~Yanhui~~, X]]	+	[[Category: Liu, M]]
-	[[Category: ~~Yuan~~, T]]	+	[[Category: Wang, J]]
-	[[Category: ~~Qinhui~~, R]]	+	[[Category: Tian, Y]]
-	[[Category: ~~Hongwei~~, W]]	+	[[Category: Xu, Y]]
-	[[Category: ~~Zihan~~, W]]	+	[[Category: Rao, Q]]

OCA: Protected "5yz0" [edit=sysop:move=sysop]

OCA — Wed, 20 Dec 2017 04:52:10 GMT

Protected "5yz0" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:52, 20 December 2017

OCA: New page: '''Unreleased structure''' The entry 5yz0 is ON HOLD Authors: Qinhui, R., Mengjie, L., Yuan, T., Zihan, W., Hongwei, W., Jiawei, W., Yanhui, X. Description: Cryo-EM Structure of human ...

OCA — Wed, 20 Dec 2017 04:52:09 GMT

New page: '''Unreleased structure''' The entry 5yz0 is ON HOLD Authors: Qinhui, R., Mengjie, L., Yuan, T., Zihan, W., Hongwei, W., Jiawei, W., Yanhui, X. Description: Cryo-EM Structure of human ...

New page

'''Unreleased structure'''

The entry 5yz0 is ON HOLD

Authors: Qinhui, R., Mengjie, L., Yuan, T., Zihan, W., Hongwei, W., Jiawei, W., Yanhui, X.

Description: Cryo-EM Structure of human ATR-ATRIP complex
[[Category: Unreleased Structures]]
[[Category: Jiawei, W]]
[[Category: Mengjie, L]]
[[Category: Yanhui, X]]
[[Category: Yuan, T]]
[[Category: Qinhui, R]]
[[Category: Hongwei, W]]
[[Category: Zihan, W]]