5z39 - Revision history

OCA at 08:44, 22 November 2023

OCA — Wed, 22 Nov 2023 08:44:39 GMT

←Older revision		Revision as of 08:44, 22 November 2023
Line 1:		Line 1:

	==Crystal structure of C terminal region of G-protein interacting protein 1 (Gip1) from Dictyostelium discoideum form II==		==Crystal structure of C terminal region of G-protein interacting protein 1 (Gip1) from Dictyostelium discoideum form II==
-	<StructureSection load='5z39' size='340' side='right' caption='[[5z39]], [[Resolution\|resolution]] 2.74Å' scene=''>	+	<StructureSection load='5z39' size='340' side='right'caption='[[5z39]], [[Resolution\|resolution]] 2.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z39]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Dicdi Dicdi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z39 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Z39 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z39]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z39 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEF:DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE'>PEF</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.74Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDB0216772 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEF:DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE'>PEF</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5z39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z39 OCA], [~~http~~://pdbe.org/5z39 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5z39 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5z39 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5z39 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z39 OCA], [https://pdbe.org/5z39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z39 RCSB], [https://www.ebi.ac.uk/pdbsum/5z39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z39 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q55BQ2_DICDI Q55BQ2_DICDI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dicdi~~]]	+	[[Category: Dictyostelium discoideum]]
-	[[Category: Kamimura, Y]]	+	[[Category: Large Structures]]
-	[[Category: Koteishi, H]]	+	[[Category: Kamimura Y]]
-	[[Category: Miyagawa, T]]	+	[[Category: Koteishi H]]
-	[[Category: Miyanaga, Y]]	+	[[Category: Miyagawa T]]
-	[[Category: Nakagawa, A]]	+	[[Category: Miyanaga Y]]
-	[[Category: Takeshita, K]]	+	[[Category: Nakagawa A]]
-	[[Category: Ueda, M]]	+	[[Category: Takeshita K]]
-	~~[[Category: Alpha helix]]~~	+	[[Category: Ueda M]]
-	~~[[Category: Chemotaxis]]~~	+
-	~~[[Category: G-protein binding]]~~	+
-	~~[[Category: Lipid binding]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Social amoebae~~]]	+

OCA at 20:50, 2 December 2018

OCA — Sun, 02 Dec 2018 20:50:05 GMT

←Older revision		Revision as of 20:50, 2 December 2018
Line 3:		Line 3:
	<StructureSection load='5z39' size='340' side='right' caption='[[5z39]], [[Resolution\|resolution]] 2.74Å' scene=''>		<StructureSection load='5z39' size='340' side='right' caption='[[5z39]], [[Resolution\|resolution]] 2.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z39]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z39 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z39]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicdi Dicdi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z39 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEF:DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE'>PEF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEF:DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE'>PEF</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DDB0216772 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z39 OCA], [http://pdbe.org/5z39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z39 RCSB], [http://www.ebi.ac.uk/pdbsum/5z39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z39 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z39 OCA], [http://pdbe.org/5z39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z39 RCSB], [http://www.ebi.ac.uk/pdbsum/5z39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z39 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G protein interacting protein 1 (Gip1) binds and sequesters heterotrimeric G proteins in the cytosolic pool, thus regulating G protein-coupled receptor (GPCR) signalling for eukaryotic chemotaxis. Here, we report the underlying structural basis of Gip1 function. The crystal structure reveals that the region of Gip1 that binds to the G protein has a cylinder-like fold with a central hydrophobic cavity composed of six alpha-helices. Mutagenesis and biochemical analyses indicate that the hydrophobic cavity and the hydrogen bond network at the entrance of the cavity are essential for complex formation with the geranylgeranyl modification on the Ggamma subunit. Mutations of the cavity impair G protein sequestration and translocation to the membrane from the cytosol upon receptor stimulation, leading to defects in chemotaxis at higher chemoattractant concentrations. These results demonstrate that the Gip1-dependent regulation of G protein shuttling ensures wide-range gradient sensing in eukaryotic chemotaxis.
		+
		+	Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis.,Miyagawa T, Koteishi H, Kamimura Y, Miyanaga Y, Takeshita K, Nakagawa A, Ueda M Nat Commun. 2018 Nov 6;9(1):4635. doi: 10.1038/s41467-018-07035-x. PMID:30401901<ref>PMID:30401901</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5z39" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dicdi]]
	[[Category: Kamimura, Y]]		[[Category: Kamimura, Y]]
	[[Category: Koteishi, H]]		[[Category: Koteishi, H]]

OCA at 07:51, 17 October 2018

OCA — Wed, 17 Oct 2018 07:51:19 GMT

←Older revision		Revision as of 07:51, 17 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5z39 is ON HOLD until Paper Publication~~	+	==Crystal structure of C terminal region of G-protein interacting protein 1 (Gip1) from Dictyostelium discoideum form II==
-		+	<StructureSection load='5z39' size='340' side='right' caption='[[5z39]], [[Resolution\|resolution]] 2.74Å' scene=''>
-	~~Authors: Miyagawa, T., Koteishi, H., Kamimura, Y., Miyanaga, Y., Takeshita, K., Nakagawa, A., Ueda, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5z39]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z39 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of C terminal region of G-protein interacting protein 1 (Gip1) from Dictyostelium discoideum form II	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHG:1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE'>LHG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEF:DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE'>PEF</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z39 OCA], [http://pdbe.org/5z39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z39 RCSB], [http://www.ebi.ac.uk/pdbsum/5z39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z39 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kamimura, Y]]
	[[Category: Koteishi, H]]		[[Category: Koteishi, H]]
		+	[[Category: Miyagawa, T]]
		+	[[Category: Miyanaga, Y]]
		+	[[Category: Nakagawa, A]]
	[[Category: Takeshita, K]]		[[Category: Takeshita, K]]
-	[[Category: Miyanaga, Y]]
	[[Category: Ueda, M]]		[[Category: Ueda, M]]
-	[[Category: ~~Kamimura, Y~~]]	+	[[Category: Alpha helix]]
-	[[Category: ~~Miyagawa, T~~]]	+	[[Category: Chemotaxis]]
-	[[Category: ~~Nakagawa, A~~]]	+	[[Category: G-protein binding]]
		+	[[Category: Lipid binding]]
		+	[[Category: Protein binding]]
		+	[[Category: Social amoebae]]

OCA at 04:58, 7 February 2018

OCA — Wed, 07 Feb 2018 04:58:03 GMT

←Older revision		Revision as of 04:58, 7 February 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5z39 is ON HOLD	+	The entry 5z39 is ON HOLD until Paper Publication

	Authors: Miyagawa, T., Koteishi, H., Kamimura, Y., Miyanaga, Y., Takeshita, K., Nakagawa, A., Ueda, M.		Authors: Miyagawa, T., Koteishi, H., Kamimura, Y., Miyanaga, Y., Takeshita, K., Nakagawa, A., Ueda, M.

-	Description: Crystal structure of C terminal region of G-protein interacting protein 1 (Gip1) from Dictyostelium discoideum	+	Description: Crystal structure of C terminal region of G-protein interacting protein 1 (Gip1) from Dictyostelium discoideum form II
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Koteishi, H]]		[[Category: Koteishi, H]]

OCA: Protected "5z39" [edit=sysop:move=sysop]

OCA — Wed, 10 Jan 2018 07:08:27 GMT

Protected "5z39" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:08, 10 January 2018

OCA: New page: '''Unreleased structure''' The entry 5z39 is ON HOLD Authors: Miyagawa, T., Koteishi, H., Kamimura, Y., Miyanaga, Y., Takeshita, K., Nakagawa, A., Ueda, M. Description: Crystal structu...

OCA — Wed, 10 Jan 2018 07:08:25 GMT

New page: '''Unreleased structure''' The entry 5z39 is ON HOLD Authors: Miyagawa, T., Koteishi, H., Kamimura, Y., Miyanaga, Y., Takeshita, K., Nakagawa, A., Ueda, M. Description: Crystal structu...

New page

'''Unreleased structure'''

The entry 5z39 is ON HOLD

Authors: Miyagawa, T., Koteishi, H., Kamimura, Y., Miyanaga, Y., Takeshita, K., Nakagawa, A., Ueda, M.

Description: Crystal structure of C terminal region of G-protein interacting protein 1 (Gip1) from Dictyostelium discoideum
[[Category: Unreleased Structures]]
[[Category: Koteishi, H]]
[[Category: Takeshita, K]]
[[Category: Miyanaga, Y]]
[[Category: Ueda, M]]
[[Category: Kamimura, Y]]
[[Category: Miyagawa, T]]
[[Category: Nakagawa, A]]