5z4i - Revision history

OCA: Redirecting to 6kcz

OCA — Wed, 21 Aug 2019 05:44:18 GMT

Redirecting to 6kcz

←Older revision		Revision as of 05:44, 21 August 2019
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-		+	#REDIRECT [[6kcz]] This PDB entry is obsolete and replaced by 6kcz
-	~~==Solution structure of the ZnF-UBP domain of USP20/VDU2==~~	+
-	~~<StructureSection load='5z4i' size='340' side='right' caption='~~[[~~5z4i]], [[NMR_Ensembles_of_Models \| 14 NMR models]]' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[5z4i~~]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z4I FirstGlance]. <br>	+
-	~~</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z4i OCA], [http://pdbe.org/5z4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z4i RCSB], [http://www.ebi.ac.uk/pdbsum/5z4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z4i ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	[[http://www.uniprot.org/uniprot/UBP20_HUMAN UBP20_HUMAN]] Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and ~~resensitization after prolonged agonist stimulation~~ by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12056827</ref> <ref>PMID:12865408</ref> <ref>PMID:15776016</ref> <ref>PMID:19424180</ref>	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Ubiquitinyl hydrolase 1]]~~	+
-	~~[[Category: Wen, Y]]~~	+
-	~~[[Category: Yang, Y]]~~	+
-	~~[[Category: Zhang, N]]~~	+
-	~~[[Category: Hydrolase]]~~	+

OCA at 05:56, 31 January 2018

OCA — Wed, 31 Jan 2018 05:56:14 GMT

←Older revision		Revision as of 05:56, 31 January 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5z4i is ~~ON HOLD~~	+	==Solution structure of the ZnF-UBP domain of USP20/VDU2==
-		+	<StructureSection load='5z4i' size='340' side='right' caption='[[5z4i]], [[NMR_Ensembles_of_Models \| 14 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5z4i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z4I FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z4i OCA], [http://pdbe.org/5z4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z4i RCSB], [http://www.ebi.ac.uk/pdbsum/5z4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z4i ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UBP20_HUMAN UBP20_HUMAN]] Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12056827</ref> <ref>PMID:12865408</ref> <ref>PMID:15776016</ref> <ref>PMID:19424180</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ubiquitinyl hydrolase 1]]
		+	[[Category: Wen, Y]]
		+	[[Category: Yang, Y]]
		+	[[Category: Zhang, N]]
		+	[[Category: Hydrolase]]

OCA: Protected "5z4i" [edit=sysop:move=sysop]

OCA — Wed, 17 Jan 2018 05:38:02 GMT

Protected "5z4i" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:38, 17 January 2018

OCA: New page: '''Unreleased structure''' The entry 5z4i is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 17 Jan 2018 05:38:01 GMT

New page: '''Unreleased structure''' The entry 5z4i is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5z4i is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]