5z53 - Revision history

OCA at 08:45, 22 November 2023

OCA — Wed, 22 Nov 2023 08:45:33 GMT

←Older revision		Revision as of 08:45, 22 November 2023
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	<StructureSection load='5z53' size='340' side='right'caption='[[5z53]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='5z53' size='340' side='right'caption='[[5z53]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z53]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fischerella_utex1931~~ Fischerella ~~utex1931~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z53 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Z53 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z53]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Fischerella_sp._TAU Fischerella sp. TAU]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z53 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HZ:AMINO({3-[(3S,8AS)-1,4-DIOXOOCTAHYDROPYRROLO[1,2-A]PYRAZIN-3-YL]PROPYL}AMINO)METHANIMINIUM'>0HZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.86Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">filC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70812 Fischerella UTEX1931])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0HZ:AMINO({3-[(3S,8AS)-1,4-DIOXOOCTAHYDROPYRROLO[1,2-A]PYRAZIN-3-YL]PROPYL}AMINO)METHANIMINIUM'>0HZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z53 OCA], [~~http~~://pdbe.org/5z53 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5z53 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5z53 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5z53 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z53 OCA], [https://pdbe.org/5z53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z53 RCSB], [https://www.ebi.ac.uk/pdbsum/5z53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z53 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1P8VSI6_9CYAN A0A1P8VSI6_9CYAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fischerella ~~utex1931~~]]	+	[[Category: Fischerella sp. TAU]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen~~, C C~~]]	+	[[Category: Chen CC]]
-	[[Category: Guo~~, R T~~]]	+	[[Category: Guo RT]]
-	[[Category: Hu~~, X Y~~]]	+	[[Category: Hu XY]]
-	[[Category: Liu~~, W D]]~~	+	[[Category: Liu WD]]
-	~~[[Category: Prenyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:42, 10 April 2019

OCA — Wed, 10 Apr 2019 07:42:11 GMT

←Older revision		Revision as of 07:42, 10 April 2019
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	==Crystal structure of a cyclase Filc from Fischerella sp. in complex with cyclo-L-Arg-D-Pro==		==Crystal structure of a cyclase Filc from Fischerella sp. in complex with cyclo-L-Arg-D-Pro==
-	<StructureSection load='5z53' size='340' side='right' caption='[[5z53]], [[Resolution\|resolution]] 1.86Å' scene=''>	+	<StructureSection load='5z53' size='340' side='right'caption='[[5z53]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5z53]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Fischerella_utex1931 Fischerella utex1931]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z53 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5z53]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Fischerella_utex1931 Fischerella utex1931]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z53 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Fischerella utex1931]]		[[Category: Fischerella utex1931]]
		+	[[Category: Large Structures]]
	[[Category: Chen, C C]]		[[Category: Chen, C C]]
	[[Category: Guo, R T]]		[[Category: Guo, R T]]

OCA at 08:32, 26 December 2018

OCA — Wed, 26 Dec 2018 08:32:00 GMT

←Older revision		Revision as of 08:32, 26 December 2018
Line 1:		Line 1:

-	==Crystal structure of ~~an enzyme~~ in complex with ~~ligand B~~==	+	==Crystal structure of a cyclase Filc from Fischerella sp. in complex with cyclo-L-Arg-D-Pro==
	<StructureSection load='5z53' size='340' side='right' caption='[[5z53]], [[Resolution\|resolution]] 1.86Å' scene=''>		<StructureSection load='5z53' size='340' side='right' caption='[[5z53]], [[Resolution\|resolution]] 1.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z53]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z53 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z53]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Fischerella_utex1931 Fischerella utex1931]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z53 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HZ:AMINO({3-[(3S,8AS)-1,4-DIOXOOCTAHYDROPYRROLO[1,2-A]PYRAZIN-3-YL]PROPYL}AMINO)METHANIMINIUM'>0HZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HZ:AMINO({3-[(3S,8AS)-1,4-DIOXOOCTAHYDROPYRROLO[1,2-A]PYRAZIN-3-YL]PROPYL}AMINO)METHANIMINIUM'>0HZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">filC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70812 Fischerella UTEX1931])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z53 OCA], [http://pdbe.org/5z53 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z53 RCSB], [http://www.ebi.ac.uk/pdbsum/5z53 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z53 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z53 OCA], [http://pdbe.org/5z53 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z53 RCSB], [http://www.ebi.ac.uk/pdbsum/5z53 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z53 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Fischerella utex1931]]
	[[Category: Chen, C C]]		[[Category: Chen, C C]]
	[[Category: Guo, R T]]		[[Category: Guo, R T]]

OCA at 08:10, 19 December 2018

OCA — Wed, 19 Dec 2018 08:10:34 GMT

←Older revision		Revision as of 08:10, 19 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5z53 is ~~ON HOLD until Jan 16 2020~~	+	==Crystal structure of an enzyme in complex with ligand B==
		+	<StructureSection load='5z53' size='340' side='right' caption='[[5z53]], [[Resolution\|resolution]] 1.86Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5z53]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z53 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z53 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0HZ:AMINO({3-[(3S,8AS)-1,4-DIOXOOCTAHYDROPYRROLO[1,2-A]PYRAZIN-3-YL]PROPYL}AMINO)METHANIMINIUM'>0HZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z53 OCA], [http://pdbe.org/5z53 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z53 RCSB], [http://www.ebi.ac.uk/pdbsum/5z53 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z53 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Found recently in stignomatales, the Stig cyclases catalyze the Cope rearrangement and intramolecular cyclization to produce complex indole alkaloids. Five crystal structures were solved of subfamily 1 and 2 Stig cyclases, which adopt a beta-sandwich fold like the non-catalytic carbohydrate-binding motif. Several complex structures were also determined of indole-based compounds, which are bound to the hydrophobic terminal cavity, where a conserved Asp residue makes an H-bond to the indole N and triggers the acid-catalyzed Cope rearrangement. Through analyzing the enzyme-ligand interactions and mutagenesis experiments, several aromatic residues were found important in catalysis. Apart from a common substrate binding mode and catalytic mechanism, potential subfamily variations that may attribute to the different product specificity are implicated. These results shall expand our scope of enzymology, in particular for further investigation of the biosynthetic Cope rearrangement.

-	~~Authors:~~ Hu, X.Y., ~~Liu~~, W.D., ~~Chen, C~~.C.~~, Guo, R~~.T.	+	The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement.,Chen CC, Hu X, Tang X, Yang Y, Ko TP, Gao J, Zheng Y, Huang JW, Yu Z, Li L, Han S, Cai N, Zhang Y, Liu W, Guo RT Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15060-15064. doi:, 10.1002/anie.201808231. Epub 2018 Oct 23. PMID:30222239<ref>PMID:30222239</ref>

-	~~Description: Crystal structure~~ of ~~an enzyme in complex with ligand B~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Chen~~, ~~C.C~~]]	+	<div class="pdbe-citations 5z53" style="background-color:#fffaf0;"></div>
-	[[Category: Hu, X.Y]]	+	== References ==
-	[[Category: ~~Guo~~, ~~R.T~~]]	+	<references/>
-	[[Category: ~~Liu, W.D~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, C C]]
		+	[[Category: Guo, R T]]
		+	[[Category: Hu, X Y]]
		+	[[Category: Liu, W D]]
		+	[[Category: Prenyltransferase]]
		+	[[Category: Transferase]]

OCA at 04:39, 31 January 2018

OCA — Wed, 31 Jan 2018 04:39:37 GMT

←Older revision		Revision as of 04:39, 31 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5z53 is ON HOLD	+	The entry 5z53 is ON HOLD until Jan 16 2020

	Authors: Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T.		Authors: Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T.
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	Description: Crystal structure of an enzyme in complex with ligand B		Description: Crystal structure of an enzyme in complex with ligand B
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Hu, X.Y]]
-	[[Category: Liu, W.D]]
	[[Category: Chen, C.C]]		[[Category: Chen, C.C]]
		+	[[Category: Hu, X.Y]]
	[[Category: Guo, R.T]]		[[Category: Guo, R.T]]
		+	[[Category: Liu, W.D]]

OCA: Protected "5z53" [edit=sysop:move=sysop]

OCA — Wed, 24 Jan 2018 17:11:50 GMT

Protected "5z53" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:11, 24 January 2018

OCA: New page: '''Unreleased structure''' The entry 5z53 is ON HOLD Authors: Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T. Description: Crystal structure of an enzyme in complex with ligand B [[Category...

OCA — Wed, 24 Jan 2018 17:11:49 GMT

New page: '''Unreleased structure''' The entry 5z53 is ON HOLD Authors: Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T. Description: Crystal structure of an enzyme in complex with ligand B [[Category...

New page

'''Unreleased structure'''

The entry 5z53 is ON HOLD

Authors: Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T.

Description: Crystal structure of an enzyme in complex with ligand B
[[Category: Unreleased Structures]]
[[Category: Hu, X.Y]]
[[Category: Liu, W.D]]
[[Category: Chen, C.C]]
[[Category: Guo, R.T]]