5z89 - Revision history

OCA at 08:49, 22 November 2023

OCA — Wed, 22 Nov 2023 08:49:41 GMT

←Older revision		Revision as of 08:49, 22 November 2023
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	<StructureSection load='5z89' size='340' side='right'caption='[[5z89]], [[Resolution\|resolution]] 1.42Å' scene=''>		<StructureSection load='5z89' size='340' side='right'caption='[[5z89]], [[Resolution\|resolution]] 1.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z89]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buchnera_hermonthica Buchnera~~ hermonthica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z89 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5Z89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z89]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Striga_hermonthica Striga hermonthica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z89 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.42Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5z82\|5z82]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z89 OCA], [https://pdbe.org/5z89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z89 RCSB], [https://www.ebi.ac.uk/pdbsum/5z89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z89 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5z89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z89 OCA], [~~http~~://pdbe.org/5z89 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5z89 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5z89 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5z89 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0M3PNA2_STRHE A0A0M3PNA2_STRHE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buchnera hermonthica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Arold, S T~~]]	+	[[Category: Striga hermonthica]]
-	[[Category: ~~Hameed, U S~~]]	+	[[Category: Arold ST]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Hameed US]]
-	~~[[Category: Striga germination signaling]]~~	+
-	~~[[Category: Strigolactone receptor~~]]	+

OCA at 21:16, 28 October 2020

OCA — Wed, 28 Oct 2020 21:16:15 GMT

←Older revision		Revision as of 21:16, 28 October 2020
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	==Structural basis for specific inhibition of highly sensitive ShHTL7 receptor==		==Structural basis for specific inhibition of highly sensitive ShHTL7 receptor==
-	<StructureSection load='5z89' size='340' side='right' caption='[[5z89]], [[Resolution\|resolution]] 1.42Å' scene=''>	+	<StructureSection load='5z89' size='340' side='right'caption='[[5z89]], [[Resolution\|resolution]] 1.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buchnera_hermonthica Buchnera hermonthica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z89 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Z89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buchnera_hermonthica Buchnera hermonthica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z89 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Z89 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5z82\|5z82]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5z82\|5z82]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5z89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z89 OCA], [http://pdbe.org/5z89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z89 RCSB], [http://www.ebi.ac.uk/pdbsum/5z89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z89 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5z89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z89 OCA], [http://pdbe.org/5z89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z89 RCSB], [http://www.ebi.ac.uk/pdbsum/5z89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z89 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Buchnera hermonthica]]		[[Category: Buchnera hermonthica]]
		+	[[Category: Large Structures]]
	[[Category: Arold, S T]]		[[Category: Arold, S T]]
	[[Category: Hameed, U S]]		[[Category: Hameed, U S]]

OCA at 10:23, 5 September 2018

OCA — Wed, 05 Sep 2018 10:23:36 GMT

←Older revision		Revision as of 10:23, 5 September 2018
Line 3:		Line 3:
	<StructureSection load='5z89' size='340' side='right' caption='[[5z89]], [[Resolution\|resolution]] 1.42Å' scene=''>		<StructureSection load='5z89' size='340' side='right' caption='[[5z89]], [[Resolution\|resolution]] 1.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z89]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z89 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z89]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buchnera_hermonthica Buchnera hermonthica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z89 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z89 OCA], [http://pdbe.org/5z89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z89 RCSB], [http://www.ebi.ac.uk/pdbsum/5z89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z89 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z89 OCA], [http://pdbe.org/5z89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z89 RCSB], [http://www.ebi.ac.uk/pdbsum/5z89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z89 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Striga hermonthica is a root parasitic plant that infests cereals, decimating yields, particularly in sub-Saharan Africa. For germination, Striga seeds require host-released strigolactones that are perceived by the family of HYPOSENSITIVE to LIGHT (ShHTL) receptors. Inhibiting seed germination would thus be a promising approach for combating Striga However, there are currently no strigolactone antagonists that specifically block ShHTLs and do not bind to DWARF14, the homologous strigolactone receptor of the host. Here, we show that the octyl phenol ethoxylate Triton X-100 inhibits S. hermonthica seed germination without affecting host plants. High-resolution X-ray structures reveal that Triton X-100 specifically plugs the catalytic pocket of ShHTL7. ShHTL7-specific inhibition by Triton X-100 demonstrates the dominant role of this particular ShHTL receptor for Striga germination. Our structural analysis provides a rationale for the broad specificity and high sensitivity of ShHTL7, and reveals that strigolactones trigger structural changes in ShHTL7 that are required for downstream signaling. Our findings identify Triton and the related 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]acetic acid as promising lead compounds for the rational design of efficient Striga-specific herbicides.
		+
		+	Structural basis for specific inhibition of the highly sensitive ShHTL7 receptor.,Shahul Hameed U, Haider I, Jamil M, Kountche BA, Guo X, Zarban RA, Kim D, Al-Babili S, Arold ST EMBO Rep. 2018 Jul 18. pii: embr.201745619. doi: 10.15252/embr.201745619. PMID:30021834<ref>PMID:30021834</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5z89" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buchnera hermonthica]]
	[[Category: Arold, S T]]		[[Category: Arold, S T]]
	[[Category: Hameed, U S]]		[[Category: Hameed, U S]]

OCA at 07:10, 25 July 2018

OCA — Wed, 25 Jul 2018 07:10:47 GMT

←Older revision		Revision as of 07:10, 25 July 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5z89 is ~~ON HOLD until Paper Publication~~	+	==Structural basis for specific inhibition of highly sensitive ShHTL7 receptor==
-		+	<StructureSection load='5z89' size='340' side='right' caption='[[5z89]], [[Resolution\|resolution]] 1.42Å' scene=''>
-	~~Authors~~: ~~Hameed~~, U.S., ~~Arold~~, S.T.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5z89]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z89 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z89 FirstGlance]. <br>
-	~~Description: Structural basis for specific inhibition of highly sensitive ShHTL7 receptor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
-	[[Category: Hameed, U.S]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5z82\|5z82]]</td></tr>
-	[[Category: ~~Arold, S.T~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z89 OCA], [http://pdbe.org/5z89 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z89 RCSB], [http://www.ebi.ac.uk/pdbsum/5z89 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z89 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arold, S T]]
		+	[[Category: Hameed, U S]]
		+	[[Category: Hydrolase]]
		+	[[Category: Striga germination signaling]]
		+	[[Category: Strigolactone receptor]]

OCA at 12:14, 11 April 2018

OCA — Wed, 11 Apr 2018 12:14:52 GMT

←Older revision		Revision as of 12:14, 11 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5z89 is ON HOLD	+	The entry 5z89 is ON HOLD until Paper Publication

	Authors: Hameed, U.S., Arold, S.T.		Authors: Hameed, U.S., Arold, S.T.

OCA: Protected "5z89" [edit=sysop:move=sysop]

OCA — Wed, 07 Feb 2018 05:02:54 GMT

Protected "5z89" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:02, 7 February 2018

OCA: New page: '''Unreleased structure''' The entry 5z89 is ON HOLD Authors: Hameed, U.S., Arold, S.T. Description: Structural basis for specific inhibition of highly sensitive ShHTL7 receptor [[Cate...

OCA — Wed, 07 Feb 2018 05:02:52 GMT

New page: '''Unreleased structure''' The entry 5z89 is ON HOLD Authors: Hameed, U.S., Arold, S.T. Description: Structural basis for specific inhibition of highly sensitive ShHTL7 receptor [[Cate...

New page

'''Unreleased structure'''

The entry 5z89 is ON HOLD

Authors: Hameed, U.S., Arold, S.T.

Description: Structural basis for specific inhibition of highly sensitive ShHTL7 receptor
[[Category: Unreleased Structures]]
[[Category: Hameed, U.S]]
[[Category: Arold, S.T]]