5z8j - Revision history

OCA at 08:49, 22 November 2023

OCA — Wed, 22 Nov 2023 08:49:43 GMT

←Older revision		Revision as of 08:49, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5z8j' size='340' side='right'caption='[[5z8j]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5z8j' size='340' side='right'caption='[[5z8j]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z8J FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AU:GOLD+ION'>AU</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>FTMT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8j OCA], [https://pdbe.org/5z8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z8j RCSB], [https://www.ebi.ac.uk/pdbsum/5z8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8j OCA], [https://pdbe.org/5z8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z8j RCSB], [https://www.ebi.ac.uk/pdbsum/5z8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>	+	[https://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ferroxidase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Zang, J]]	+	[[Category: Zang J]]
-	[[Category: Zhao, G]]	+	[[Category: Zhao G]]
-	[[Category: Zheng, B]]	+	[[Category: Zheng B]]
-	~~[[Category: Cysteine]]~~	+
-	~~[[Category: Gold]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Mitochondrail ferritin]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:12, 18 March 2021

OCA — Thu, 18 Mar 2021 10:12:17 GMT

←Older revision		Revision as of 10:12, 18 March 2021
Line 3:		Line 3:
	<StructureSection load='5z8j' size='340' side='right'caption='[[5z8j]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5z8j' size='340' side='right'caption='[[5z8j]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z8j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Z8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z8J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTMT ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTMT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5z8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8j OCA], [~~http~~://pdbe.org/5z8j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5z8j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5z8j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8j OCA], [https://pdbe.org/5z8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z8j RCSB], [https://www.ebi.ac.uk/pdbsum/5z8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8j ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>	+	[[https://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:50, 28 August 2019

OCA — Wed, 28 Aug 2019 15:50:04 GMT

←Older revision		Revision as of 15:50, 28 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5z8j is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Human mitochondrial ferritin mutant - E27C/E62C/C102G/C130G==
		+	<StructureSection load='5z8j' size='340' side='right'caption='[[5z8j]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5z8j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z8J FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8j OCA], [http://pdbe.org/5z8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z8j RCSB], [http://www.ebi.ac.uk/pdbsum/5z8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8j ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Protein nanocages have emerged as popular nanocarriers for either drug delivery or biotemplates for the preparation of nanomaterials. However, only three interfaces, namely exterior surface, intersubunit and inner cavity, have been used as reaction sites for the above purposes with all known protein nanocages. On the other hand, how to control the site of Au NCs formed within a targeted protein template while maintaining the functionality of protein itself remains challenging. RESULTS: In this work, inspired by compartmentalization in living systems, we firstly come up with the conception of "intrasubunit interfaces", located within subunit of protein nanocage. We built a new, specific compartment for fabrication of gold nanoclusters by genetic modification of the inherent ferroxidase center located within four-alpha-helix bundle of each ferritin subunit. This newly built compartment not only realizes the site-directed synthesis of gold nanoclusters but also has no effect on the functionality of ferritin itself such as encapsulation by its inner cavity. These redesigned composites can be further applied as fluorescent imaging agent and carriers for preparation of hybrid nanomaterials. CONCLUSIONS: The designing strategy of intrasubunit interfaces opens a new way for future applications of cage-like proteins.

-	~~Authors: Zang~~, J., Zheng, B., ~~Zhao~~, G.	+	Design and site-directed compartmentalization of gold nanoclusters within the intrasubunit interfaces of ferritin nanocage.,Zang J, Zheng B, Zhang X, Arosio P, Zhao G J Nanobiotechnology. 2019 Jul 5;17(1):79. doi: 10.1186/s12951-019-0512-0. PMID:31277668<ref>PMID:31277668</ref>

-	~~Description: Human mitochondrial ferritin mutant~~ -~~E27C~~/~~E62C~~/~~C102G~~/~~C130G~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 5z8j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ferroxidase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Zang, J]]
	[[Category: Zhao, G]]		[[Category: Zhao, G]]
	[[Category: Zheng, B]]		[[Category: Zheng, B]]
-	[[Category: ~~Zang, J~~]]	+	[[Category: Cysteine]]
		+	[[Category: Gold]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Mitochondrail ferritin]]
		+	[[Category: Oxidoreductase]]

OCA at 04:44, 2 January 2019

OCA — Wed, 02 Jan 2019 04:44:51 GMT

←Older revision		Revision as of 04:44, 2 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5z8j is ON HOLD	+	The entry 5z8j is ON HOLD until Paper Publication

	Authors: Zang, J., Zheng, B., Zhao, G.		Authors: Zang, J., Zheng, B., Zhao, G.
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	Description: Human mitochondrial ferritin mutant -E27C/E62C/C102G/C130G		Description: Human mitochondrial ferritin mutant -E27C/E62C/C102G/C130G
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Zhao, G]]
	[[Category: Zheng, B]]		[[Category: Zheng, B]]
	[[Category: Zang, J]]		[[Category: Zang, J]]
-	[[Category: Zhao, G]]

OCA: Protected "5z8j" [edit=sysop:move=sysop]

OCA — Wed, 07 Feb 2018 05:03:42 GMT

Protected "5z8j" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:03, 7 February 2018

OCA: New page: '''Unreleased structure''' The entry 5z8j is ON HOLD Authors: Zang, J., Zheng, B., Zhao, G. Description: Human mitochondrial ferritin mutant -E27C/E62C/C102G/C130G [[Category: Unreleas...

OCA — Wed, 07 Feb 2018 05:03:41 GMT

New page: '''Unreleased structure''' The entry 5z8j is ON HOLD Authors: Zang, J., Zheng, B., Zhao, G. Description: Human mitochondrial ferritin mutant -E27C/E62C/C102G/C130G [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 5z8j is ON HOLD

Authors: Zang, J., Zheng, B., Zhao, G.

Description: Human mitochondrial ferritin mutant -E27C/E62C/C102G/C130G
[[Category: Unreleased Structures]]
[[Category: Zheng, B]]
[[Category: Zang, J]]
[[Category: Zhao, G]]