5zal - Revision history

OCA at 22:51, 10 April 2020

OCA — Fri, 10 Apr 2020 22:51:01 GMT

←Older revision		Revision as of 22:51, 10 April 2020
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	<SX load='5zal' size='340' side='right' viewer='molstar' caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>		<SX load='5zal' size='340' side='right' viewer='molstar' caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DICER1, DICER, HERNA, KIAA0928 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TARBP2, TRBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DICER1, DICER, HERNA, KIAA0928 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TARBP2, TRBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zal OCA], [http://pdbe.org/5zal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zal RCSB], [http://www.ebi.ac.uk/pdbsum/5zal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zal ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zal OCA], [http://pdbe.org/5zal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zal RCSB], [http://www.ebi.ac.uk/pdbsum/5zal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zal ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 20:17, 6 March 2020

OCA — Fri, 06 Mar 2020 20:17:20 GMT

←Older revision		Revision as of 20:17, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate==		==Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate==
-	<~~StructureSection~~ load='5zal' size='340' side='right'caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>	+	<SX load='5zal' size='340' side='right' viewer='molstar' caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>		<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:32, 6 November 2019

OCA — Wed, 06 Nov 2019 07:32:01 GMT

←Older revision		Revision as of 07:32, 6 November 2019
Line 1:		Line 1:

	==Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate==		==Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate==
-	<StructureSection load='5zal' size='340' side='right' caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>	+	<StructureSection load='5zal' size='340' side='right'caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>		<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5zal" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zal" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dicer\|Dicer]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ribonuclease III]]		[[Category: Ribonuclease III]]
	[[Category: Cheng, H]]		[[Category: Cheng, H]]

OCA at 22:05, 9 August 2018

OCA — Thu, 09 Aug 2018 22:05:18 GMT

←Older revision		Revision as of 22:05, 9 August 2018
Line 3:		Line 3:
	<StructureSection load='5zal' size='340' side='right' caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>		<StructureSection load='5zal' size='340' side='right' caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DICER1, DICER, HERNA, KIAA0928 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TARBP2, TRBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zal OCA], [http://pdbe.org/5zal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zal RCSB], [http://www.ebi.ac.uk/pdbsum/5zal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zal ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zal OCA], [http://pdbe.org/5zal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zal RCSB], [http://www.ebi.ac.uk/pdbsum/5zal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zal ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DICER_HUMAN DICER_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.<ref>PMID:15242644</ref> <ref>PMID:16271387</ref> <ref>PMID:16289642</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref> [[http://www.uniprot.org/uniprot/TRBP2_HUMAN TRBP2_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.<ref>PMID:12475984</ref> <ref>PMID:16271387</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref>		[[http://www.uniprot.org/uniprot/DICER_HUMAN DICER_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.<ref>PMID:15242644</ref> <ref>PMID:16271387</ref> <ref>PMID:16289642</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref> [[http://www.uniprot.org/uniprot/TRBP2_HUMAN TRBP2_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.<ref>PMID:12475984</ref> <ref>PMID:16271387</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human Dicer (hDicer) is a multi-domain protein belonging to the RNase III family. It plays pivotal roles in small RNA biogenesis during the RNA interference (RNAi) pathway by processing a diverse range of double-stranded RNA (dsRNA) precursors to generate approximately 22 nt microRNA (miRNA) or small interfering RNA (siRNA) products for sequence-directed gene silencing. In this work, we solved the cryoelectron microscopy (cryo-EM) structure of hDicer in complex with its cofactor protein TRBP and revealed the precise spatial arrangement of hDicer's multiple domains. We further solved structures of the hDicer-TRBP complex bound with pre-let-7 RNA in two distinct conformations. In combination with biochemical analysis, these structures reveal a property of the hDicer-TRBP complex to promote the stability of pre-miRNA's stem duplex in a pre-dicing state. These results provide insights into the mechanism of RNA processing by hDicer and illustrate the regulatory role of hDicer's N-terminal helicase domain.
		+
		+	Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate.,Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang QC, Wang HW Cell. 2018 May 17;173(5):1191-1203.e12. doi: 10.1016/j.cell.2018.03.080. Epub, 2018 Apr 26. PMID:29706542<ref>PMID:29706542</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5zal" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Ribonuclease III]]		[[Category: Ribonuclease III]]
	[[Category: Cheng, H]]		[[Category: Cheng, H]]

OCA at 06:14, 9 May 2018

OCA — Wed, 09 May 2018 06:14:30 GMT

←Older revision		Revision as of 06:14, 9 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zal is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate==
-		+	<StructureSection load='5zal' size='340' side='right' caption='[[5zal]], [[Resolution\|resolution]] 4.70Å' scene=''>
-	~~Authors~~: ~~Liu~~, Z., ~~Wang, J~~., ~~Cheng~~, H., ~~Ke, X~~., ~~Sun~~, L., ~~Zhang~~, Q.C., ~~Wang~~, H.-W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zal]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZAL FirstGlance]. <br>
-	~~Description~~: ~~Cryo~~-~~EM structure~~ of ~~human Dicer~~ and ~~its complexes with a~~ pre-miRNA ~~substrate~~	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zal OCA], [http://pdbe.org/5zal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zal RCSB], [http://www.ebi.ac.uk/pdbsum/5zal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zal ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DICER_HUMAN DICER_HUMAN]] Defects in DICER1 are a cause of pleuropulmonary blastoma (PPB) [MIM:[http://omim.org/entry/601200 601200]]. PPB is a rare pediatric tumor of the lung that arises during fetal lung development and is often part of an inherited cancer syndrome. PPBs contain both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst walls and form a dense 'cambium' layer beneath the epithelial lining. In a subset of patients, overgrowth of the mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis.<ref>PMID:21882293</ref> <ref>PMID:19556464</ref> Defects in DICER1 are the cause of goiter multinodular type 1 with or without Sertoli-Leydig cell tumors (MNG1) [MIM:[http://omim.org/entry/138800 138800]]. A common disorder characterized by nodular overgrowth of the thyroid gland. Some individuals may also develop Sertoli-Leydig cell tumors, usually of the ovary.<ref>PMID:21882293</ref> <ref>PMID:21205968</ref> Note=DICER1 mutations have been found in uterine cervix embryonal rhabdomyosarcoma, primitive neuroectodermal tumor, Wilms tumor, pulmonary sequestration and juvenile intestinal polyp (PubMed:21882293). Somatic missense mutations affecting the RNase IIIb domain of DICER1 are common in non-epithelial ovarian tumors. These mutations do not abolish DICER1 function but alter it in specific cell types, a novel mechanism through which perturbation of microRNA processing may be oncogenic (PubMed:22187960).<ref>PMID:21882293</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DICER_HUMAN DICER_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.<ref>PMID:15242644</ref> <ref>PMID:16271387</ref> <ref>PMID:16289642</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref> [[http://www.uniprot.org/uniprot/TRBP2_HUMAN TRBP2_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.<ref>PMID:12475984</ref> <ref>PMID:16271387</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ribonuclease III]]
		+	[[Category: Cheng, H]]
		+	[[Category: Ke, X]]
	[[Category: Liu, Z]]		[[Category: Liu, Z]]
-	[[Category: ~~Zhang~~, ~~Q.C]]~~	+	[[Category: Sun, L]]
-	~~[[Category: Ke, X~~]]	+	[[Category: Wang, H W]]
-	[[Category: Wang, H.-W]]	+
	[[Category: Wang, J]]		[[Category: Wang, J]]
-	[[Category: ~~Sun~~, L]]	+	[[Category: Zhang, Q C]]
-	[[Category: ~~Cheng, H~~]]	+	[[Category: Cryo-em]]
		+	[[Category: Dicer]]
		+	[[Category: Hydrolase-protein binding-rna complex]]
		+	[[Category: Protein binding]]
		+	[[Category: Rna interference]]
		+	[[Category: Trbp]]

OCA at 05:56, 21 March 2018

OCA — Wed, 21 Mar 2018 05:56:02 GMT

←Older revision		Revision as of 05:56, 21 March 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zal is ON HOLD	+	The entry 5zal is ON HOLD until Paper Publication

-	Authors: ~~Zhongmin~~, L., ~~Jia~~, W., ~~Hang~~, C., ~~Xin~~, K., ~~Lei~~, S., ~~Qiangfeng~~, C.Z., ~~Hongwei~~, W.	+	Authors: Liu, Z., Wang, J., Cheng, H., Ke, X., Sun, L., Zhang, Q.C., Wang, H.-W.

	Description: Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate		Description: Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Xin~~, K]]	+	[[Category: Liu, Z]]
-	[[Category: ~~Qiangfeng~~, C.Z]]	+	[[Category: Zhang, Q.C]]
-	[[Category: ~~Zhongmin~~, L]]	+	[[Category: Ke, X]]
-	[[Category: ~~Hang~~, C]]	+	[[Category: Wang, H.-W]]
-	[[Category: ~~Jia~~, W]]	+	[[Category: Wang, J]]
-	[[Category: ~~Lei~~, S]]	+	[[Category: Sun, L]]
-	[[Category: ~~Hongwei~~, W]]	+	[[Category: Cheng, H]]

OCA: Protected "5zal" [edit=sysop:move=sysop]

OCA — Thu, 15 Feb 2018 05:12:16 GMT

Protected "5zal" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:12, 15 February 2018

OCA: New page: '''Unreleased structure''' The entry 5zal is ON HOLD Authors: Zhongmin, L., Jia, W., Hang, C., Xin, K., Lei, S., Qiangfeng, C.Z., Hongwei, W. Description: Cryo-EM structure of human Di...

OCA — Thu, 15 Feb 2018 05:12:14 GMT

New page: '''Unreleased structure''' The entry 5zal is ON HOLD Authors: Zhongmin, L., Jia, W., Hang, C., Xin, K., Lei, S., Qiangfeng, C.Z., Hongwei, W. Description: Cryo-EM structure of human Di...

New page

'''Unreleased structure'''

The entry 5zal is ON HOLD

Authors: Zhongmin, L., Jia, W., Hang, C., Xin, K., Lei, S., Qiangfeng, C.Z., Hongwei, W.

Description: Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate
[[Category: Unreleased Structures]]
[[Category: Xin, K]]
[[Category: Qiangfeng, C.Z]]
[[Category: Zhongmin, L]]
[[Category: Hang, C]]
[[Category: Jia, W]]
[[Category: Lei, S]]
[[Category: Hongwei, W]]